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Abstract

The primary aim of the Danish enterovirus (EV) surveillance system is to document absence of poliovirus infection. The conflict in Syria has left many children unvaccinated and movement from areas with polio cases to Europe calls for increased awareness to detect and respond to virus-transmission in a timely manner. We evaluate the national EV laboratory surveillance, to generate recommendations for system strengthening. The system was analysed for completeness of viral typing analysis and clinical information and timeliness of specimen collection, laboratory results and reporting of clinical information. Of 23,720 specimens screened, 2,202 (9.3%) were EV-positive. Submission of cerebrospinal fluid and faecal specimens from primary diagnostic laboratories was 79.5% complete (845/1,063), and varied by laboratory and patient age. EV genotypes were determined in 68.5% (979/1,430) of laboratory-confirmed cases, clinical information was available for 63.1% (903/1,430). Primary diagnostic results were available after a median of 1.4 days, typing results after 17 days, detailed clinical information after 33 days. The large number of samples typed demonstrated continued monitoring of EV-circulation in Denmark. The system could be strengthened by increasing the collection of supplementary faecal specimens, improving communication with primary diagnostic laboratories, adapting the laboratory typing methodology and collecting clinical information with electronic forms.

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/content/10.2807/1560-7917.ES.2016.21.18.30218
2016-05-05
2024-03-28
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.18.30218
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References

  1. Palacios G, Oberste MS. Enteroviruses as agents of emerging infectious diseases. J Neurovirol. 2005;11(5):424-33.  https://doi.org/10.1080/13550280591002531  PMID: 16287683 
  2. Rhoades RE, Tabor-Godwin JM, Tsueng G, Feuer R. Enterovirus infections of the central nervous system. Virology. 2011;411(2):288-305.  https://doi.org/10.1016/j.virol.2010.12.014  PMID: 21251690 
  3. Fischer TK, Nielsen AY, Sydenham TV, Andersen PH, Andersen B, Midgley SE. Emergence of enterovirus 71 C4a in Denmark, 2009 to 2013. Euro Surveill. 2014;19(38):20911.  https://doi.org/10.2807/1560-7917.ES2014.19.38.20911  PMID: 25306878 
  4. World Health Organization (WHO). Europe achieves historical milestone as Region is declared polio polio-free. 21 Jun 2002. Copenhagen: WHO; 2002. Available from: http://www.who.int/mediacentre/news/releases/releaseeuro02/en/
  5. Shulman LM, Gavrilin E, Jorba J, Martin J, Burns CC, Manor Y, et al. Genotype - Phenotype Identification (GPI) group. Molecular epidemiology of silent introduction and sustained transmission of wild poliovirus type 1, Israel, 2013. Euro Surveill. 2014;19(7):20709.  https://doi.org/10.2807/1560-7917.ES2014.19.7.20709  PMID: 24576471 
  6. Mundel T, Orenstein WA. No country is safe without global eradication of poliomyelitis. N Engl J Med. 2013;369(21):2045-6.  https://doi.org/10.1056/NEJMe1311591  PMID: 24256383 
  7. Eichner M, Brockmann SO. Polio emergence in Syria and Israel endangers Europe. Lancet. 2013;382(9907):1777.  https://doi.org/10.1016/S0140-6736(13)62220-5  PMID: 24211043 
  8. European Centre for Disease prevention and Control (ECDC). Suspected outbreak of poliomyelitis in Syria: Risk of importation and spread of poliovirus in the EU. Stockholm: ECDC; 2013. Available from: http://ecdc.europa.eu/en/publications/Publications/RRA%20poliomyelitis%20Syria%2021%2010%202013.pdf
  9. European Centre for Disease prevention and Control (ECDC). Detection and control of poliovirus transmission in the European Union and European Economic Area Risk mitigation. Stockholm: ECDC; 2014. Available from: http://ecdc.europa.eu/en/publications/_layouts/forms/Publication_DispForm.aspx?List=4f55ad51-4aed-4d32-b960-af70113dbb90&ID=1034
  10. World Health Organization Regionl office for Europe (WHO). Report of the 27th Meeting of the European Regional Certification Commission for Poliomyelitis Eradication. Copenhagen, Denmark 30-31 May. Copenhagen: WHO; 2013. Available from: http://www.euro.who.int/__data/assets/pdf_file/0016/200752/Report-of-the-27th-Meeting-of-the-European-Regional-Certification-Commission-for-Poliomyelitis-Eradication.pdf
  11. Heymann D, Ahmed Q. The polio eradication end game : what it means for Europe. Euro Surveill. 2014;19(7):20702.  PMID: 24576468 
  12. German RR, Lee LM, Horan JM, Milstein RL, Pertowski CA, Waller MNGuidelines Working Group Centers for Disease Control and Prevention (CDC). Updated guidelines for evaluating public health surveillance systems: recommendations from the Guidelines Working Group. MMWR Recomm Rep. 2001;50(RR-13):1-35, quiz CE1-7. PMID: 18634202 
  13. World Health Organization (WHO). WHO-recommended standards for surveillance of selected vaccine-preventable diseases. Geneva: WHO; 2008; Available from: http://www.who.int/immunization/documents/WHO_VB_03.01/en/
  14. Centers for Disease Control and Prevention (CDC). Manual for the Surveillance of Vaccine-Preventable Diseases. Chapter 18: Surveillance indicators. Atlanta: CDC; 2011. Available from: http://www.cdc.gov/vaccines/pubs/surv-manual/chpt18-surv-indicators.html
  15. Nielsen ACY, Böttiger B, Midgley SE, Nielsen LP. A novel enterovirus and parechovirus multiplex one-step real-time PCR-validation and clinical experience. J Virol Methods. 2013;193(2):359-63.  https://doi.org/10.1016/j.jviromet.2013.06.038  PMID: 23845901 
  16. Nasri D, Bouslama L, Omar S, Saoudin H, Bourlet T, Aouni M, et al. Typing of human enterovirus by partial sequencing of VP2. J Clin Microbiol. 2007;45(8):2370-9.  https://doi.org/10.1128/JCM.00093-07  PMID: 17537940 
  17. Nix WA, Oberste MS, Pallansch MA. Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens. J Clin Microbiol. 2006;44(8):2698-704.  https://doi.org/10.1128/JCM.00542-06  PMID: 16891480 
  18. World Health Organization (WHO). Supplement to the WHO Polio Laboratory Manual. An alternative test algorithm for poliovirus isolation and characterization. Available from: http://apps.who.int/immunization_monitoring/Supplement_polio_lab_manual.pdf
  19. Midgley SE, Christiansen CB, Poulsen MW, Hansen CH, Fischer TK. Emergence of enterovirus D68 in Denmark, June 2014 to February 2015. Euro Surveill. 2015;20(17):21105.  https://doi.org/10.2807/1560-7917.ES2015.20.17.21105  PMID: 25955773 
  20. Badran SA, Midgley S, Andersen P, Böttiger B. Clinical and virological features of enterovirus 71 infections in Denmark, 2005 to 2008. Scand J Infect Dis. 2011;43(8):642-8.  https://doi.org/10.3109/00365548.2011.577094  PMID: 21526904 
  21. Jajosky RA, Groseclose SL. Evaluation of reporting timeliness of public health surveillance systems for infectious diseases. BMC Public Health. 2004;4(29).  https://doi.org/10.1186/1471-2458-4-29  PMID: 15274746 
  22. European Centre for Disease Prevention and Control (ECDC). Data quality monitoring and surveillance system evaluation. A handbook of methods and applications. Stockholm: ECDC; 2014. Available from: http://www.ecdc.europa.eu/en/publications/Publications/Data-quality-monitoring-surveillance-system-evaluation-Sept-2014.pdf
  23. Centers for Disease Control and Prevention (CDC). Tracking progress toward global polio eradication--worldwide, 2009-2010. MMWR Morb Mortal Wkly Rep. 2011;60(14):441-445.
  24. Centers for Disease Control and Prevention (CDC). Enterovirus surveillance--United States, 2002-2004. MMWR Morb Mortal Wkly Rep. 2006;55(6):153-6. PMID: 16484979 
  25. Hawkes MT, Vaudry W. Nonpolio enterovirus infection in the neonate and young infant. Paediatr Child Health. 2005;10(7):383-8. PMID: 19668644 
  26. Kargar M, Sadeghipour S, Nategh R. Environmental surveillance of Non-Polio Enteroviruses in Iran. Virol J. 2009;6(149).  https://doi.org/10.1186/1743-422X-6-149  PMID: 19781063 
  27. Afifi SS, Zaki SA, Mohamed AF, El Hosseiny H. Isolation and identification of non-polio enteroviruses from children in different Egyptian governorates. Aust J Basic and Appl Sci. 2009;3(4):3230-8.
  28. Khetsuriani N, Lamonte-Fowlkes A, Oberst S, Pallansch MACenters for Disease Control and Prevention. Enterovirus surveillance--United States, 1970-2005. MMWR Surveill Summ. 2006;55(8) SS08;1-20. PMID: 16971890 
  29. Ward M, Brandsema P, van Straten E, Bosman A. Electronic reporting improves timeliness and completeness of infectious disease notification, The Netherlands, 2003. Euro Surveill. 2005;10(1):27-30. PMID: 15701937 
  30. Jansson A, Arneborn M, Skärlund K, Ekdahl K. Timeliness of case reporting in the Swedish statutory surveillance of communicable diseases 1998--2002. Scand J Infect Dis. 2004;36(11-12):865-72.  https://doi.org/10.1080/00365540410025348  PMID: 15764175 
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