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Abstract

Since 2007, livestock-associated meticillin-resistant (LA-MRSA) has become the predominant MRSA clade isolated from humans in the Netherlands. To assess possible temporal changes, we molecularly characterised over 9,000 LA-MRSA isolates submitted from 2003 to 2014 to the Dutch MRSA surveillance. After an initial rapid increase with a peak in 2009 (n = 1,368), the total number of submitted LA-MRSA isolates has been slowly decreasing to 968 in 2014 and over 80% of LA-MRSA belonged to one of three predominant MLVA/-types. Next generation sequencing (n=118) showed that MT569/t034 isolates were genetically more diverse than MT398/t011 and MT572/t108. Concurrent with the decrease in LA-MRSA, fewer people reported having contact with livestock and this was most prominent for people carrying MT569/t034 LA-MRSA. The proportion of LA-MRSA isolated from infection-related materials increased from 6% in 2009, to 13% in 2014 and most of these isolates originated from patients older than 50 years of age. Remarkably, 83% of these patients reported not having contact with livestock. The results reveal an ongoing change in the genotypic and epidemiological characteristics of Dutch LA-MRSA isolated from humans with the emergence of a LA-MRSA subclade independent of livestock exposure, suggesting LA-MRSA starts to resemble non-LA-MRSA in terms of transmissibility and pathogenicity.

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/content/10.2807/1560-7917.ES.2016.21.21.30236
2016-05-26
2024-04-19
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.21.30236
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Changing characteristics of livestock-associated meticillin-resistant Staphylococcus aureus isolated from humans – emergence of a subclade transmitted without livestock exposure, the Netherlands, 2003 to 2014
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Thijs+Bosch&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bosch Thijs</a>, <a href="/search?value1=Martijn+van+Luit&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van Luit Martijn</a>, <a href="/search?value1=Gerlinde+N+Pluister&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pluister Gerlinde N</a>, <a href="/search?value1=Dineke+Frentz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Frentz Dineke</a>, <a href="/search?value1=Anja+Haenen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Haenen Anja</a>, <a href="/search?value1=Fabian+Landman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Landman Fabian</a>, <a href="/search?value1=Sandra+Witteveen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Witteveen Sandra</a>, <a href="/search?value1=Naomi+van+Marm-Wattimena&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van Marm-Wattimena Naomi</a>, <a href="/search?value1=Han+G+van+der+Heide&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van der Heide Han G</a>, <a href="/search?value1=Leo+M+Schouls&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schouls Leo M</a></span>. Changing characteristics of livestock-associated meticillin-resistant Staphylococcus aureus isolated from humans – emergence of a subclade transmitted without livestock exposure, the Netherlands, 2003 to 2014. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(21):pii=30236. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.21.30236" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.21.30236</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 22 Jul 2015;&nbsp;&nbsp; <span class="generated">Accepted</span>: 11 Jan 2016 </span> </p>
/content/10.2807/1560-7917.ES.2016.21.21.30236
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