1887
Rapid communication Open Access
Like 0

Abstract

We describe Zika virus (ZIKV) vertical transmission in an imported case in Spain, in a 17-week pregnant woman. ZIKV IgG, IgM and RNA were detected in serum in week 17. At 19 weeks, ultrasound scan revealed fetal malformations and ZIKV was detected in the amniotic fluid. Pregnancy was terminated at week 21; autopsy of the fetus revealed bilateral hydrocephalus, brain microcalcifications and arthrogryposis multiplex congenita. ZIKV was detected in the umbilical cord and brain tissue.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2016.21.24.30261
2016-06-16
2017-12-18
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.24.30261
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/21/24/eurosurv-21-30261-1.html?itemId=/content/10.2807/1560-7917.ES.2016.21.24.30261&mimeType=html&fmt=ahah

References

  1. Balm MND, Lee CK, Lee HK, Chiu L, Koay ESC, Tang JW. A diagnostic polymerase chain reaction assay for Zika virus. J Med Virol. 2012;84(9):1501-5.  https://doi.org/10.1002/jmv.23241  PMID: 22825831 
  2. Waggoner JJ, Pinsky BA. Zika Virus: Diagnostics for an Emerging Pandemic Threat. J Clin Microbiol. 2016;54(4):860-7.  https://doi.org/10.1128/JCM.00279-16  PMID: 26888897 
  3. Pan American Health Organization (PAHO) / World Health Organization (WHO). Epidemiological Alert. Zika virus infection. 7 May 2016. Washington, D.C.: PAHO/WHO. Available from: http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=30075&lang=en
  4. Pan American Health Organization (PAHO) / World Health Organization (WHO). Timeline of Emergence of Zika virus in the Americas. Washington, D.C.: PAHO/WHO; [Accessed Jun 2016]. Available from: http://www.paho.org/hq/index.php?option=com_content&view=article&id=11959&Itemid=41711&lang=en
  5. World Health Organization (WHO). Guillain-Barré syndrome – Colombia and Venezuela [Accessed 15 Jun 2016]. Geneva: WHO. Available from: http://www.who.int/csr/don/12-february-2016-gbs-colombia-venezuela/en/
  6. Saiz J-C, Vázquez-Calvo Á, Blázquez AB, Merino-Ramos T, Escribano-Romero E, Martín-Acebes MA. Zika Virus: the Latest Newcomer. Front Microbiol. 2016;7:496.  https://doi.org/10.3389/fmicb.2016.00496  PMID: 27148186 
  7. Martínez de Salazar P, Suy A, Sánchez-Montalvá A, Rodó C, Salvador F, Molina I. Zika fever. Enferm Infecc Microbiol Clin. 2016;34(4):247-52.  https://doi.org/10.1016/j.eimc.2016.02.016  PMID: 26993436 
  8. Schuler-Faccini L, Ribeiro EM, Feitosa IML, Horovitz DDG, Cavalcanti DP, Pessoa A, et al. Brazilian Medical Genetics Society–Zika Embryopathy Task Force. Possible Association Between Zika Virus Infection and Microcephaly - Brazil, 2015. MMWR Morb Mortal Wkly Rep. 2016;65(3):59-62.  https://doi.org/10.15585/mmwr.mm6503e2  PMID: 26820244 
  9. Driggers RW, Ho C-Y, Korhonen EM, Kuivanen S, Jääskeläinen AJ, Smura T, et al. Zika Virus Infection with Prolonged Maternal Viremia and Fetal Brain Abnormalities. N Engl J Med. 2016;374(22):2142-51.  https://doi.org/10.1056/NEJMoa1601824  PMID: 27028667 
  10. Petersen LR, Jamieson DJ, Powers AM, Honein MA. Zika Virus. N Engl J Med. 2016;374(16):1552-63.  https://doi.org/10.1056/NEJMra1602113  PMID: 27028561 
  11. Johansson MA, Mier-Y-Teran-Romero L, Reefhuis J, Gilboa SM, Hills SL. Zika and the Risk of Microcephaly. N Engl J Med. 2016;NEJMp1605367.  https://doi.org/10.1056/NEJMp1605367  PMID: 27222919 
  12. Brasil P, Pereira JP Jr, Raja Gabaglia C, Damasceno L, Wakimoto M, Ribeiro Nogueira RM, et al. Zika Virus Infection in Pregnant Women in Rio de Janeiro - Preliminary Report. N Engl J Med. 2016; NEJMoa1602412. http://dx.doi.org/ https://doi.org/10.1056/NEJMoa1602412  PMID:26943629
  13. Sarno M, Sacramento GA, Khouri R, do Rosário MS, Costa F, Archanjo G, et al. Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise. PLoS Negl Trop Dis. 2016;10(2):e0004517.  https://doi.org/10.1371/journal.pntd.0004517  PMID: 26914330 
  14. Bayer A, Lennemann NJ, Ouyang Y, Bramley JC, Morosky S, Marques ETDA Jr, et al. Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection. Cell Host Microbe. 2016;19(5):705-12.  https://doi.org/10.1016/j.chom.2016.03.008  PMID: 27066743 
  15. Mlakar J, Korva M, Tul N, Popović M, Poljšak-Prijatelj M, Mraz J, et al. Zika Virus Associated with Microcephaly. N Engl J Med. 2016;374(10):951-8.  https://doi.org/10.1056/NEJMoa1600651  PMID: 26862926 
  16. Miner JJ, Diamond MS. Understanding How Zika Virus Enters and Infects Neural Target Cells. Cell Stem Cell. 2016;18(5):559-60.  https://doi.org/10.1016/j.stem.2016.04.009  PMID: 27152436 
  17. Nowakowski TJ, Pollen AA, Di Lullo E, Sandoval-Espinosa C, Bershteyn M, Kriegstein AR. Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells. Cell Stem Cell. 2016;18(5):591-6.  https://doi.org/10.1016/j.stem.2016.03.012  PMID: 27038591 
  18. Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, et al. Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell Stem Cell. 2016;18(5):587-90.  https://doi.org/10.1016/j.stem.2016.02.016  PMID: 26952870 
  19. World Health Organization (WHO). Situation report: Zika virus microcephaly, Guillain-Barré syndrome [Accessed 6 Jun 2016]. Geneva: WHO. Available from: http://apps.who.int/iris/bitstream/10665/208816/1/zikasitrep_2Jun2016_eng.pdf?ua=1
  20. Ministerio de Sanidad, Servicios Sociales e Igualdad. Gobierno de España. [Diagnosed cases]. [Accessed 6 Jun 2016]. Spanish. Available from: http://www.msssi.es/en/profesionales/saludPublica/zika/casosDiagnosticados/home.htm
  21. Bachiller-Luque P, Domínguez-Gil González M, Álvarez-Manzanares J, Vázquez A, De Ory F, Sánchez-Seco Fariñas MP. First case of imported Zika virus infection in Spain. Enferm Infecc Microbiol Clin. 2016;34(4):243-6.  https://doi.org/10.1016/j.eimc.2016.02.012  PMID: 26994814 
  22. Bocanegra C. Zika virus infection in pregnant women in Barcelona, Spain. Clin Microbiol Infect. 2016;S1198-743X(16)30043-X.  https://doi.org/10.1016/j.cmi.2016.03.025  PMID:27063354
/content/10.2807/1560-7917.ES.2016.21.24.30261
Loading

Data & Media loading...

Comment has been disabled for this content
Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error