1887
Surveillance and outbreak report Open Access
Like 0

Abstract

In Denmark, universal screening of pregnant women for hepatitis B has been in place since November 2005, with the first two years as a trial period with enhanced surveillance. It is unknown what the change to universal screening without enhanced surveillance has meant for vaccination coverage among children born to hepatitis B surface antigen (HBsAg)-positive mothers and what risk factors exist for incomplete vaccination. This retrospective cohort study included 699 children of mothers positive for HBsAg. Information on vaccination and risk factors was collected from central registers. In total, 93% (651/699) of the children were vaccinated within 48 hours of birth, with considerable variation between birthplaces. Only 64% (306/475) of the children had received all four vaccinations through their general practitioner (GP) at the age of two years, and 10% (47/475) of the children had received no hepatitis B vaccinations at all. Enhanced surveillance was correlated positively with coverage of birth vaccination but not with coverage at the GP. No or few prenatal examinations were a risk factor for incomplete vaccination at the GP. Maternity wards and GPs are encouraged to revise their vaccination procedures and routines for pregnant women, mothers with chronic HBV infection and their children.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2016.21.7.30136
2016-02-18
2017-11-18
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.7.30136
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/21/7/eurosurv-21-30136-2.html?itemId=/content/10.2807/1560-7917.ES.2016.21.7.30136&mimeType=html&fmt=ahah

References

  1. World Health Organization (WHO). Hepatitis B fact sheet N 204. Geneva: WHO. [Accessed: 15 Feb 2011]. Available from: http://www.who.int/mediacentre/factsheets/fs204/en/
  2. Mast EE, Weinbaum CM, Fiore AE, Alter MJ, Bell BP, Finelli L, et al. A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP) Part II: immunization of adults. MMWR Recomm Rep. 2006;55(RR-16):1-33; quiz CE1-4.
  3. McMahon BJAW, Alward WL, Hall DB, Heyward WL, Bender TR, Francis DP, et al. Acute hepatitis B virus infection: relation of age to the clinical expression of disease and subsequent development of the carrier state. J Infect Dis. 1985;151(4):599-603.  https://doi.org/10.1093/infdis/151.4.599  PMID: 3973412 
  4. Søborg B, Cowan S. Acute and chronic hepatitis 2011. EPI-NEWS No 3, 2013. Available from: http://www.ssi.dk/English/News/EPI-NEWS/2013/No%203%20-%202013.aspx
  5. Qureshi K, Cowan S. Chronic hepatitis B 2004. EPI-NEWS No. 41, 2005. Available from: http://www.ssi.dk/~/media/Indhold/EN%20-%20engelsk/EPI-NEWS/2005/PDF/EPI-NEWS%20-%202005%20-%20No%2041.ashx
  6. Cowan S, Qureshi K. Universal HBV screening during pregnancy. EPI-NEWS No. 42/43, 2007. Available from: http://www.ssi.dk/~/media/Indhold/EN%20-%20engelsk/EPI-NEWS/2007/PDF/EPI-NEWS%20-%202007%20-%20No%2042-43.ashx
  7. Cowan S, Quershi K, Bagdonaite J. General hepatitis B screening during pregnancy. EPI - NEWS No. 18, 2006. Available from: http://www.ssi.dk/~/media/Indhold/EN%20-%20engelsk/EPI-NEWS/2006/PDF/EPI-NEWS%20-%202006%20-%20No%2018.ashx
  8. Cowan SA, Bagdonaite J, Qureshi K. Universal hepatitis B screening of pregnant women in Denmark ascertains substantial additional infections: results from the first five months. Euro Surveill. 2006;11(6):E060608.3. PMID: 16819119 
  9. Cowan S, Christiansen AH, Soeborg B, Wojcik O, Roth L. Hepatitis B, HIV and syphilis screening of pregnant women, 2010. EPI-NEWS No. 15, 2011. Available from: http://www.ssi.dk/English/News/EPI-NEWS/2011/No%2015%20-%202011.aspx
  10. Cowan SA. Denmark decides not to introduce hepatitis B into the childhood vaccination programme. Euro Surveill. 2005;10(11):E051103.3. PMID: 16794274 
  11. Andersen PH, Valentiner-Branth P, Knudsen LK, Christiansen AH. Commentary on hepatitis B vaccination in the Danish childhood vaccination programme. EPI-NEWS No. 50, 2013. Available from: http://www.ssi.dk/English/News/EPI-NEWS/2013/No%2050%20-%202013.aspx
  12. Cowan SA. Denmark scales up hepatitis B screening and vaccination for risk groups. Euro Surveill. 2005;10(11):E051103.4. PMID: 16794275 
  13. Danish Health and Medicines Authority. Vejledning om HIV (human immundefekt virus) og hepatitis B og C virus. Forebyggelse af blodbåren smitte, diagnostik og håndtering i sundhedsvæsenet og på andre arbejdspladser. [Guidance on HIV (human immunodeficiency virus) and hepatitis B and C virus]. Copenhagen: Sundhedsstyrelsen; 2013. Danish. Available from: http://sundhedsstyrelsen.dk/~/media/AD9E0753B12546B8AEA323BF02AC3D2C.ashx
  14. Harder KM, Cowan S, Eriksen MB, Krarup HB, Christensen PB. Universal screening for hepatitis B among pregnant women led to 96% vaccination coverage among newborns of HBsAg positive mothers in Denmark. Vaccine. 2011;29(50):9303-7.  https://doi.org/10.1016/j.vaccine.2011.10.028  PMID: 22019756 
  15. Danish Health and Medicines Authority. Vejledning om generel screening af gravide for infektion med hepatitis B virus, human immundefekt virus (HIV) og syfilis. [Guidance on universal screening of pregnant women for infection with hepatitis B virus, human immunodeficiency virus (HIV) and syphilis]. Copenhagen: Sundhedsstyrelsen; 2010. Danish. Available from: http://sundhedsstyrelsen.dk/~/media/36E8C229A5D54471B775A48F9D2F9333.ashx
  16. The Ministry of Health and Prevention. Bekendtgørelse om ændring af bekendtgørelse om gratis hepatitisvaccination til særligt udsatte persongrupper. Ministeriet for Sundhed og Forebyggelse. BEK nr 904 af 05/09/2008. [Departmental order concerning amendment of departmental order concerning hepatitis B vaccination for free to especially vulnerable groups of persons].Copenhagen: Ministeriet for Sundhed og forebyggelse; 2008. Danish. Available from: https://www.retsinformation.dk/Forms/R0710.aspx?id=121285
  17. Malig C. The Civil Registration System in Denmark - Technical Papers Number 66, International Institute for Vital Registration and Statistics. Bethesda: International Institute for Vital Registration and Statistics; 1996. Available from: http://www.cdc.gov/nchs/data/isp/066_The_Civil_Registration_System_in_Denmark.pdf
  18. Giraudon I, Permalloo N, Nixon G, Charlett A, Cohuet S, Mandal S, et al. Factors associated with incomplete vaccination of babies at risk of perinatal hepatitis B transmission: a London study in 2006. Vaccine. 2009;27(14):2016-22.  https://doi.org/10.1016/j.vaccine.2008.12.016  PMID: 19135494 
  19. Heininger U, Vaudaux B, Nidecker M, Pfister RE, Posfay-Barbe KM, Bachofner M, et al. Evaluation of the compliance with recommended procedures in newborns exposed to HBsAg-positive mothers: a multicenter collaborative study. Pediatr Infect Dis J. 2010;29(3):248-50.  https://doi.org/10.1097/INF.0b013e3181bd7f89  PMID: 19935120 
  20. van Steenbergen JE, Leentvaar-Kuijpers A, Baayen D, Dukers HT, van Doornum GJ, van den Hoek JA, et al. Evaluation of the hepatitis B antenatal screening and neonatal immunization program in Amsterdam, 1993-1998. Vaccine. 2001;20(1-2):7-11.  https://doi.org/10.1016/S0264-410X(01)00315-2  PMID: 11567738 
  21. Danish Health and Medicines Authority. Produktresumé for Engerix-B 10 mikrogram/0,5ml, injektionsvæske, suspension i fyldt injektionssprøjte. [The Summary of Product Characteristics (SPC) for Engerix - B]. Copenhagen: Lægemiddelstyrelsen; 2015. Danish. Available from: http://www.produktresume.dk/docushare/dsweb/GetRendition/Document-13802/html
  22. Mast E, Goldstein S, Ward J. Hepatitis B vaccines. In: Plotkin SA, Orenstein WA, Offit PA (editors). Vaccines. 5th edition. Philadelphia: Saunders Elsevier; 2008. p 205-43.
  23. Rhiner J, Pfister R, Nassehi Tschopp Y, Bucher HU. Selective immunisation strategy to protect newborns at risk for transmission of hepatitis B: retrospective audit of vaccine uptake. Swiss Med Wkly. 2007;137(37-38):531-5. PMID: 17990143 
  24. Tharmaphornpilas P, Rasdjarmrearnsook AO, Plianpanich S, Sa-nguanmoo P, Poovorawan Y. Increased risk of developing chronic HBV infection in infants born to chronically HBV infected mothers as a result of delayed second dose of hepatitis B vaccination. Vaccine. 2009;27(44):6110-5.  https://doi.org/10.1016/j.vaccine.2009.08.034  PMID: 19716459 
  25. Beckers K, Schaad UB, Heininger U. Compliance with antenatal screening for hepatitis B surface antigen carrier status in pregnant women and consecutive procedures in exposed newborns. Eur J Pediatr. 2004;163(11):654-7. PMID: 15316775 
  26. Danish Health and Medicines Authority. Vejledning om helbredsmæssige forhold hos udenlandske adoptivbørn og børn i indvandrerfamilier [Guidance on healthrelated circumstances in adopted children from abroad and in children living in immigrant families]. Copenhagen: Sundhedsstyrelsen; 1992. Danish. Available from: https://sundhedsstyrelsen.dk/da/udgivelser/1992/vejledning-om-helbredsmaessige-forhold-hos-udenlandske-adoptivboern-og-boern-i-indvandrerfamilier
  27. Stadler LP, Mezoff AG, Staat MA. Hepatitis B virus screening for internationally adopted children. Pediatrics. 2008;122(6):1223-8.  https://doi.org/10.1542/peds.2007-2559  PMID: 19047238 
  28. Hepatitis B vaccines. Wkly Epidemiol Rec. 2009;84(40):405-19. PMID: 19817017 
  29. Lernout T, Hendrickx G, Vorsters A, Mosina L, Emiroglu N, Van Damme P. A cohesive European policy for hepatitis B vaccination, are we there yet? Clin Microbiol Infect. 2014;20(Suppl 5):19-24.  https://doi.org/10.1111/1469-0691.12535  PMID: 24829936 
  30. Krause TG, Valentiner-Branth P, Cowan S, Mølbak K. Reminder concerning lacking childhood vaccinations. EPI-NEWS No. 20, 2014. Available from: http://www.ssi.dk/English/News/EPI-NEWS/2014/No%2020%20-%202014.aspx
/content/10.2807/1560-7917.ES.2016.21.7.30136
Loading

Data & Media loading...

Comment has been disabled for this content
Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error