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Abstract

Background

Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic threat of global public health concern and dromedary camels are the source of zoonotic infection. Although MERS-CoV is enzootic in dromedaries in Africa as well as the Middle East, zoonotic disease has not been reported in Africa. : In an abattoir in Kano, Nigeria, we tested nasal swabs from camels and investigated 261 humans with repeated occupational exposure to camels, many of whom also reported drinking fresh camel milk (n = 138) or urine (n = 94) or using camel urine for medicinal purposes (n = 96). : Weekly MERS-CoV RNA detection in January–February 2016 ranged from 0–8.4% of camels sampled. None of the abattoir workers with exposure to camels had evidence of neutralising antibody to MERS-CoV. : There is a need for more studies to investigate whether or not zoonotic transmission of MERS-CoV does take place in Africa.

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/content/10.2807/1560-7917.ES.2018.23.32.1800175
2018-08-09
2024-04-20
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2018.23.32.1800175
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References

  1. World Health Organization (WHO). Countries agree next steps to combat global health threat by MERS-CoV. Geneva: WHO; 2017. [Accessed 26 Mar 2018]. Available from: http://www.who.int/emergencies/mers-cov/accelerating-response/en/
  2. Chu DK, Oladipo JO, Perera RA, Kuranga SA, Chan SM, Poon LL, et al. Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria, 2015. Euro Surveill. 2015;20(49):30086.  https://doi.org/10.2807/1560-7917.ES.2015.20.49.30086  PMID: 26676406 
  3. Chu DK, Poon LL, Gomaa MM, Shehata MM, Perera RA, Abu Zeid D, et al. MERS coronaviruses in dromedary camels, Egypt. Emerg Infect Dis. 2014;20(6):1049-53.  https://doi.org/10.3201/eid2006.140299  PMID: 24856660 
  4. Miguel E, Chevalier V, Ayelet G, Ben Bencheikh MN, Boussini H, Chu DK, et al. Risk factors for MERS coronavirus infection in dromedary camels in Burkina Faso, Ethiopia, and Morocco, 2015. Euro Surveill. 2017;22(13):30498.  https://doi.org/10.2807/1560-7917.ES.2017.22.13.30498  PMID: 28382915 
  5. Reusken CB, Raj VS, Koopmans MP, Haagmans BL. Cross host transmission in the emergence of MERS coronavirus. Curr Opin Virol. 2016;16:55-62.  https://doi.org/10.1016/j.coviro.2016.01.004  PMID: 26826951 
  6. Saqib M, Sieberg A, Hussain MH, Mansoor MK, Zohaib A, Lattwein E, et al. Serologic Evidence for MERS-CoV Infection in Dromedary Camels, Punjab, Pakistan, 2012-2015. Emerg Infect Dis. 2017;23(3):550-1.  https://doi.org/10.3201/eid2303.161285  PMID: 28221127 
  7. Chu DKW, Hui KPY, Perera RAPM, Miguel E, Niemeyer D, Zhao J, et al. MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity. Proc Natl Acad Sci USA. 2018;115(12):3144-9.  https://doi.org/10.1073/pnas.1718769115  PMID: 29507189 
  8. Müller MA, Meyer B, Corman VM, Al-Masri M, Turkestani A, Ritz D, et al. Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study. Lancet Infect Dis. 2015;15(5):559-64.  https://doi.org/10.1016/S1473-3099(15)70090-3  PMID: 25863564 
  9. Munyua P, Corman VM, Bitek A, Osoro E, Meyer B, Müller MA, et al. No Serologic Evidence of Middle East Respiratory Syndrome Coronavirus Infection Among Camel Farmers Exposed to Highly Seropositive Camel Herds: A Household Linked Study, Kenya, 2013. Am J Trop Med Hyg. 2017;96(6):1318-24.  https://doi.org/10.4269/ajtmh.16-0880  PMID: 28719257 
  10. Liljander A, Meyer B, Jores J, Müller MA, Lattwein E, Njeru I, et al. MERS-CoV Antibodies in Humans, Africa, 2013-2014. Emerg Infect Dis. 2016;22(6):1086-9.  https://doi.org/10.3201/eid2206.160064  PMID: 27071076 
  11. Corman VM, Eckerle I, Bleicker T, Zaki A, Landt O, Eschbach-Bludau M, et al. Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction. Euro Surveill. 2012;17(39):20285.  https://doi.org/10.2807/ese.17.39.20285-en  PMID: 23041020 
  12. Perera RA, Wang P, Gomaa MR, El-Shesheny R, Kandeil A, Bagato O, et al. Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013. Euro Surveill. 2013;18(36):20574.  https://doi.org/10.2807/1560-7917.ES2013.18.36.20574  PMID: 24079378 
  13. Ali MA, Shehata MM, Gomaa MR, Kandeil A, El-Shesheny R, Kayed AS, et al. Systematic, active surveillance for Middle East respiratory syndrome coronavirus in camels in Egypt. Emerg Microbes Infect. 2017;6(1):e1.  https://doi.org/10.1038/emi.2016.130  PMID: 28050021 
  14. Park SW, Perera RA, Choe PG, Lau EH, Choi SJ, Chun JY, et al. Comparison of serological assays in human Middle East respiratory syndrome (MERS)-coronavirus infection. Euro Surveill. 2015;20(41):30042.  https://doi.org/10.2807/1560-7917.ES.2015.20.41.30042  PMID: 26538277 
  15. Reusken CB, Farag EA, Haagmans BL, Mohran KA, Godeke GJ 5th, Raj S, et al. Occupational Exposure to Dromedaries and Risk for MERS-CoV Infection, Qatar, 2013-2014. Emerg Infect Dis. 2015;21(8):1422-5.  https://doi.org/10.3201/eid2108.150481  PMID: 26196891 
  16. Choe PG, Perera RAPM, Park WB, Song KH, Bang JH, Kim ES, et al. MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015. Emerg Infect Dis. 2017;23(7):1079-84.  https://doi.org/10.3201/eid2307.170310  PMID: 28585916 
  17. Ko JH, Müller MA, Seok H, Park GE, Lee JY, Cho SY, et al. Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity. Diagn Microbiol Infect Dis. 2017;89(2):106-11.  https://doi.org/10.1016/j.diagmicrobio.2017.07.006  PMID: 28821364 
  18. Zhao J, Alshukairi AN, Baharoon SA, Ahmed WA, Bokhari AA, Nehdi AM, et al. Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses. Sci Immunol. 2017;2(14):eaan5393.  https://doi.org/10.1126/sciimmunol.aan5393  PMID: 28778905 
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