Eurosurveillance, Volume
9, Issue
12,
01 December 2004
Guidelines
Bichat guidelines for the clinical management of haemorrhagic fever viruses and bioterrorism-related haemorrhagic fever viruses
P Bossi1, A Tegnell2, A Baka3, F van Loock2, J Hendriks2, A Werner2, Heinrich Maidhof2, Georgios Gouvras2
Citation style for this article: Bossi P, Tegnell A, Baka A, van Loock F, Hendriks J, Werner A, Maidhof H, Gouvras G. Bichat guidelines for the clinical management of haemorrhagic fever viruses and bioterrorism-related haemorrhagic fever viruses. Euro Surveill. 2004;9(12):pii=504. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=504
Date of submission:
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Philippe Bossi*, Anders Tegnell, Agoritsa Baka, Frank Van Loock, Jan
Hendriks, Albrecht Werner, Heinrich Maidhof, Georgios Gouvras
Task Force on Biological and Chemical Agent Threats, Public Health Directorate,
European Commission, Luxembourg
*Corresponding author: P. Bossi, Pitié-Salpêtrière
Hospital, Paris, France, email: philippe.bossi@psl.ap-hop-paris.fr
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Haemorrhagic fever viruses (HFVs) are a diverse
group of viruses that cause a clinical disease associated with fever
and bleeding disorder. HFVs that are associated with a potential biological
threat are Ebola and Marburg viruses (Filoviridae), Lassa fever and New
World arenaviruses (Machupo, Junin, Guanarito and Sabia viruses) (Arenaviridae),
Rift Valley fever (Bunyaviridae) and yellow fever, Omsk haemorrhagic
fever, and Kyanasur Forest disease (Flaviviridae). In terms of biological
warfare concerning dengue, Crimean-Congo haemorrhagic fever and Hantaviruses,
there is not sufficient knowledge to include them as a major biological
threat. Dengue virus is the only one of these that cannot be transmitted
via aerosol. Crimean-Congo haemorrhagic fever and the agents of haemorrhagic
fever with renal syndrome appear difficult to weaponise. Ribavirin is
recommended for the treatment and the prophylaxis of the arenaviruses
and the bunyaviruses, but is not effective for the other families. All
patients must be isolated and receive intensive supportive therapy.
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