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Abstract

In July–18 August 2025, 171 autochthonous cases with West Nile virus (WNV) infection were confirmed in Lazio, Italy: four asymptomatic blood donors, 110 with WNV fever, 57 with neuroinvasive syndrome and nine deaths. WNV lineage 2 was detected in two neuroinvasive cases. Infection with WNV was confirmed in 28 horses, five crows and a pool. We present the preliminary epidemiological and phylogenetic analysis of the outbreak and the public health measures taken within a One Health approach.

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/content/10.2807/1560-7917.ES.2025.30.35.2500634
2025-09-04
2026-04-18
/content/10.2807/1560-7917.ES.2025.30.35.2500634
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Outbreak of autochthonous West Nile virus infection in Lazio region, Italy, July to August 2025: preliminary investigation
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Ilaria+Mussetto&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mussetto Ilaria</a>, <a href="/search?value1=Andrea+Bongiovanni&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bongiovanni Andrea</a>, <a href="/search?value1=Francesca+Colavita&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Colavita Francesca</a>, <a href="/search?value1=Cristina+Giambi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Giambi Cristina</a>, <a href="/search?value1=Marcello+Giovanni+Sala&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sala Marcello Giovanni</a>, <a href="/search?value1=Cosmo+Del+Borgo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Del Borgo Cosmo</a>, <a href="/search?value1=Fabrizio+Carletti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Carletti Fabrizio</a>, <a href="/search?value1=Maria+Teresa+Scicluna&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Scicluna Maria Teresa</a>, <a href="/search?value1=Alessandro+Zerbetto&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zerbetto Alessandro</a>, <a href="/search?value1=Angela+Corpolongo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Corpolongo Angela</a>, <a href="/search?value1=Federico+Romiti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Romiti Federico</a>, <a href="/search?value1=Maria+Beatrice+Valli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Valli Maria Beatrice</a>, <a href="/search?value1=Stefania+Vaglio&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vaglio Stefania</a>, <a href="/search?value1=Roberto+Giammattei&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Giammattei Roberto</a>, <a href="/search?value1=Paola+Scognamiglio&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Scognamiglio Paola</a>, <a href="/search?value1=Gabriella+De+Carli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">De Carli Gabriella</a>, <a href="/search?value1=Alessandro+Agresta&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Agresta Alessandro</a>, <a href="/search?value1=Claudio+De+Liberato&option1=author&noRedirect=true" class="nonDisambigAuthorLink">De Liberato Claudio</a>, <a href="/search?value1=Giuseppe+Di+Luzio&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Di Luzio Giuseppe</a>, <a href="/search?value1=Florindo+Micarelli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Micarelli Florindo</a>, <a href="/search?value1=Emanuele+Nicastri&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nicastri Emanuele</a>, <a href="/search?value1=Andrea+Siddu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Siddu Andrea</a>, <a href="/search?value1=Valeria+Ficarelli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ficarelli Valeria</a>, <a href="/search?value1=Enrico+Girardi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Girardi Enrico</a>, <a href="/search?value1=Fabrizio+Maggi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Maggi Fabrizio</a>, <a href="/search?value1=Francesco+Vairo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vairo Francesco</a>, <a href="/search?value1=the+Lazio+WNV+Outbreak+Group&option1=author&noRedirect=true" class="nonDisambigAuthorLink">the Lazio WNV Outbreak Group</a></span>. Outbreak of autochthonous West Nile virus infection in Lazio region, Italy, July to August 2025: preliminary investigation. <a href="/content/ecdc">Euro Surveill.</a> 2025;30(35):pii=2500634. <a href="https://doi.org/10.2807/1560-7917.ES.2025.30.35.2500634" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2025.30.35.2500634</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 20 Aug 2025;&nbsp;&nbsp; <span class="generated">Accepted</span>: 04 Sept 2025 </span> </p>
/content/10.2807/1560-7917.ES.2025.30.35.2500634
/content/10.2807/1560-7917.ES.2025.30.35.2500634
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