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Abstract

BACKGROUND

HIV screening strategies in alternative settings, such as emergency departments (EDs), aim to increase diagnosis of occult infections and achieve 95–95–95 targets for 2030.

AIM

To assess the effectiveness of an opt-in HIV screening strategy in EDs based on six clinical scenarios from a 2020 Spanish consensus document, while examining patient characteristics and linkage to-care.

METHODS

This descriptive, multicentre, retrospective study analysed epidemiological, clinical, and linkage-to-care data of individuals aged ≥ 18 years newly diagnosed with HIV between July 2021 and March 2024 in 17 EDs covering 73% of the population in Catalonia, Spain.

RESULTS

From 23,105 HIV serologies performed, there were 172 new diagnoses (positivity rate: 0.7%). Of these, 88.4% (152/172) were assigned male at birth, had a median age of 39 years (IQR: 30–50), and 47.9% (81/169) were Spanish. Sexual transmission was reported in 75.6% (130/172) of cases, with 55.5% (81/146) heterosexual. Fiebig stage data, available in 78.5% (135/172) of cases, showed 57.8% (78/135) had acute infection. Advanced HIV was found in 24.2% (30/124). Diagnoses related to the six clinical scenarios accounted for 54.6% (94/172) of cases. For all new diagnoses, 82.0% (137/167) were linked to specialised healthcare and started antiretroviral treatment within 9 days (IQR: 4–17), with no significant differences regarding urban/rural hospital coverage areas.

CONCLUSION

An opt-in HIV screening strategy in the ED is feasible and effective, especially in detecting highly transmissible patients with acute infection. However, one in five newly diagnosed individuals remained untreated, highlighting the need for improved linkage to care.

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/content/10.2807/1560-7917.ES.2025.30.47.2400781
2025-11-27
2026-04-21
/content/10.2807/1560-7917.ES.2025.30.47.2400781
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References

  1. World Health Organization (WHO). HIV data and statistics. Geneva; WHO. [Accessed: 5 Apr 2025]. Available from: https://www.who.int/teams/global-hiv-hepatitis-and-stis-programmes/hiv/strategic-information/hiv-data-and-statistics
  2. Agustí C, Montoliu A, Mascort J, Carrillo R, Almeda J, Elorza JM, et al. Missed opportunities for HIV testing of patients diagnosed with an indicator condition in primary care in Catalonia, Spain. Sex Transm Infect. 2016;92(5):387-92.  https://doi.org/10.1136/sextrans-2015-052328  PMID: 26888659 
  3. Youssef E, Wright J, Delpech V, Davies K, Brown A, Cooper V, et al. Factors associated with testing for HIV in people aged ≥50 years: a qualitative study. BMC Public Health. 2018;18(1):1204.  https://doi.org/10.1186/s12889-018-6118-x  PMID: 30367609 
  4. Rava M, Domínguez-Domínguez L, Bisbal O, López-Cortés LF, Busca C, Antela A, et al. Late presentation for HIV remains a major health issue in Spain: Results from a multicenter cohort study, 2004-2018. PLoS One. 2021;16(4):e0249864.  https://doi.org/10.1371/journal.pone.0249864  PMID: 33882093 
  5. Moreno S, Berenguer J, Fuster-Ruizdeapodaca MJ, García Ontiveros M. Detección temprana. Enferm Infecc Microbiol Clin. 2018;36:35-9.  https://doi.org/10.1016/S0213-005X(18)30245-3 
  6. Marks G, Crepaz N, Senterfitt JW, Janssen RS. Meta-analysis of high-risk sexual behavior in persons aware and unaware they are infected with HIV in the United States: implications for HIV prevention programs. J Acquir Immune Defic Syndr. 2005;39(4):446-53.  https://doi.org/10.1097/01.qai.0000151079.33935.79  PMID: 16010168 
  7. Marks G, Crepaz N, Janssen RS. Estimating sexual transmission of HIV from persons aware and unaware that they are infected with the virus in the USA. AIDS. 2006;20(10):1447-50.  https://doi.org/10.1097/01.aids.0000233579.79714.8d  PMID: 16791020 
  8. National Centre for Epidemiology, Institute of Health Carlos III (ISCIII-CNE). Vigilancia epidemiológica del VIH y el SIDA en España, 2022. Sistema de información sobre nuevos diagnósticos de VIH y registro nacional de casos de SIDA. [HIV and AIDS epidemiological surveillance in Spain, 2022: New HIV diagnoses information system and national AIDS case registry]. Madrid: ISCIII-CNE; 2023. Spanish. Available from: sanidad.gob.es/ciudadanos/enfLesiones/enfTransmisibles/sida/vigilancia/docs/Informe_VIH_SIDA_2023.pdf
  9. Centre d’Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT). Vigilància Epidemiològica de la infecció pel VIH i la SIDA a Barcelona. Informe anual 2022. [HIV and AIDS epidemiological surveillance in Catalonia. Annual report 2022]. Badalona: CEEISCAT; 2023. Catalan. Available from: aspb.cat/wp-content/uploads/2023/11/ASPB-vigilancia-vih-sida-barcelona-2022-30112023.pdf
  10. Joint United Nations Programme on HIV/AIDS (UNAIDS). Understanding Fast-Track: accelerating action to end the AIDS epidemic by 2030. Geneva: UNAIDS; 2015. [Accessed: 10 January 2021]. Available from: unaids.org/sites/default/files/media_asset/201506_JC2743_Understanding_FastTrack_en.pdf
  11. National Centre for Epidemiology, Institute of Health Carlos III (ISCIII-CNE). Actualización del Continuo de Atención del VIH en España, 2021. [Update of the HIV Continuum of Care in Spain, 2021]. Madrid: ISCIII-CNE; 2023. Spanish. Available from: sanidad.gob.es/ciudadanos/enfLesiones/enfTransmisibles/sida/vigilancia/docs/Continuo_atencion_VIH_mayo_2023.pdf
  12. González Del Castillo J. Papel actual de los servicios de urgencias hospitalarios en la lucha contra la pandemia VIH. [Current role of hospital emergency departments in the fight against the human immunodeficiency virus infection pandemic]. Emergencias. 2021;33(1):7-8. PMID: 33496393 
  13. Valero-Verdejo L, Hueso-Montoro C, Pérez-Morente . Evaluation of HIV screening in hospital emergency services. Systematic review. Int Emerg Nurs. 2023;71:101355.  https://doi.org/10.1016/j.ienj.2023.101355  PMID: 37852058 
  14. Gillet C, Darling KEA, Senn N, Cavassini M, Hugli O. Targeted versus non-targeted HIV testing offered via electronic questionnaire in a Swiss emergency department: A randomized controlled study. PLoS One. 2018;13(3):e0190767.  https://doi.org/10.1371/journal.pone.0190767  PMID: 29513659 
  15. Reyes-Urueña J, Fernàndez-López L, Force L, Daza M, Agustí C, Casabona J. Estudio del impacto a nivel de salud pública del cribado universal del virus de la inmunodeficiencia humana en un servicio de Urgencias. [Level of impact on the public health of universal human immunodeficiency virus screening in an Emergency Department]. Enferm Infecc Microbiol Clin. 2017;35(7):434-7.  https://doi.org/10.1016/j.eimc.2015.06.014  PMID: 26341042 
  16. The Lancet HIV. Opt-out HIV testing in the UK. Lancet HIV. 2023;10(6):e351.  https://doi.org/10.1016/S2352-3018(23)00117-0  PMID: 37270223 
  17. Prabhu VS, Farnham PG, Hutchinson AB, Soorapanth S, Heffelfinger JD, Golden MR, et al. Cost-effectiveness of HIV screening in STD clinics, emergency departments, and inpatient units: a model-based analysis. PLoS One. 2011;6(5):e19936.  https://doi.org/10.1371/journal.pone.0019936  PMID: 21625489 
  18. Paltiel AD, Weinstein MC, Kimmel AD, Seage GR 3rd, Losina E, Zhang H, et al. Expanded screening for HIV in the United States--an analysis of cost-effectiveness. N Engl J Med. 2005;352(6):586-95.  https://doi.org/10.1056/NEJMsa042088  PMID: 15703423 
  19. Bauman LJ, Braunstein S, Calderon Y, Chhabra R, Cutler B, Leider J, et al. Barriers and facilitators of linkage to HIV primary care in New York City. J Acquir Immune Defic Syndr. 2013;64(01) Suppl 1;S20-6. https://doi.org/10.1056/NEJMsa042088  PMID: 15703423 
  20. González Del Castillo J, Burillo-Putze G, Cabello A, Curran A, Jaloud Saavedra E, Malchair P, et al. Recomendaciones dirigidas a los servicios de urgencias para el diagnóstico precoz de pacientes con sospecha de infección por VIH y su derivación para estudio y seguimiento. [Recommendations for the early diagnosis of suspected human immunodeficiency virus infection in the emergency department and the referral of patients for follow-up: a consensus statement of the Spanish Society of Emergency Medicine (SEMES)]. Emergencias. 2020;32(6):416-26. PMID: 33275363 
  21. González Del Castillo J, Mirò E, Miguens I, Trenc P, Espinosa B, Piedrafita L, et al. Feasibility of a selective targeted strategy of HIV testing in emergency departments: a before-after study. [Emergency HIV network investigators. Feasibility of a selective targeted strategy of HIV testing in emergency departments: a before-after study]. Eur J Emerg Med. 2024;31(1):29-38.  https://doi.org/10.1097/MEJ.0000000000001078  PMID: 37729041 
  22. Miró E, Miró Ò, Varón A, Marrón P, Canóniga C, Salgado P, et al. Urgències VIHgila. Impacto de una formación específica y generalizada de los profesionales de enfermería en el despistaje en urgencias de infección oculta por VIH: experiencia del proyecto "Urgències VIHgila". Emergencias (Madr). 2024;36(3):188-96.  https://doi.org/10.55633/s3me/019.2024 
  23. Miró O, Miró E, Carbó M, Saura M, Rebollo A, de Paz R, et al. [Emergency detection of HIV infection in patients consulting for conditions potentially related to occult infection: Initial results of the "Urgències VIHgila" program]. Rev Esp Quimioter. 2023;36(2):169-79.  https://doi.org/10.37201/req/085.2022  PMID: 36645021 
  24. Fiebig EW, Wright DJ, Rawal BD, Garrett PE, Schumacher RT, Peddada L, et al. Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection. AIDS. 2003;17(13):1871-9.  https://doi.org/10.1097/00002030-200309050-00005  PMID: 12960819 
  25. McMichael AJ, Borrow P, Tomaras GD, Goonetilleke N, Haynes BF. The immune response during acute HIV-1 infection: clues for vaccine development. Nat Rev Immunol. 2010;10(1):11-23.  https://doi.org/10.1038/nri2674  PMID: 20010788 
  26. Branson BM, Handsfield HH, Lampe MA, Janssen RS, Taylor AW, Lyss SB, et al. Revised recommendations for HIV testing of adults, adolescents, and pregnant women in health-care settings. MMWR Recomm Rep. 2006;55(RR-14):1-17, quiz CE1-4. PMID: 16988643 
  27. Sullivan AK, Raben D, Reekie J, Rayment M, Mocroft A, Esser S, et al. Feasibility and effectiveness of indicator condition-guided testing for HIV: results from HIDES I (HIV indicator diseases across Europe study). PLoS One. 2013;8(1):e52845.  https://doi.org/10.1371/journal.pone.0052845  PMID: 23341910 
  28. Spanish Ministry of Health, Social Services and Equality. Guía de recomendaciones para el diagnóstico precoz de VIH en el ámbito sanitario, 2014. [Guidelines for early HIV diagnosis in healthcare settings]. Madrid: Spanish Ministry of Health; 2014. Spanish. Available from: sanidad.gob.es/ciudadanos/enfLesiones/enfTransmisibles/sida/docs/GuiaRecomendacionesDiagnosticoPrecozVIH.pdf
  29. Urgències VIHgila group and the Catalan Health Department. Informe del Programa Urgències VIHgila. [Urgències VIHgila programme report]. [Accessed: 22 Nov 2024]. Catalan. Available from: https://www.urgencies-vihgila.cat/
  30. Puiguriguer Ferrando J. Intoxicaciones y VIH: otra nueva oportunidad. [Poisoning and HIV: another new opportunity]. Emergencias. 2023;35(2):85-6. PMID: 37038936 
  31. Losada A, Supervía A, Vallecillo G, Petrus C, Aranda D, Chen J, et al. Intoxicaciones por drogas de abuso: características diferenciales en población VIH. [Patients with drug-abuse poisoning with and without HIV infection: differential characteristics]. Emergencias. 2023;35(2):103-8. PMID: 37038940 
  32. Gwadz M, Leonard NR, Honig S, Freeman R, Kutnick A, Ritchie AS. Doing battle with "the monster:" how high-risk heterosexuals experience and successfully manage HIV stigma as a barrier to HIV testing. Int J Equity Health. 2018;17(1):46.  https://doi.org/10.1186/s12939-018-0761-9  PMID: 29678188 
  33. Van der Bij AK, Dukers NH, Coutinho RA, Fennema HS. Low HIV-testing rates and awareness of HIV infection among high-risk heterosexual STI clinic attendees in The Netherlands. Eur J Public Health. 2008;18(4):376-9.  https://doi.org/10.1093/eurpub/ckm120  PMID: 18381296 
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