1887
Skip to content
Research Open Access
Like 0

Abstract

BACKGROUND

Pregnant women in the Netherlands are screened for HIV during the first trimester. Insight into characteristics of women diagnosed with HIV may help identify groups who could benefit from testing strategies.

AIM

We assessed the contribution of HIV diagnoses during pregnancy to the total number of diagnoses among women in the Netherlands between 2016 and 2023 and identified socioeconomic characteristics of women with an antenatal diagnosis.

METHODS

In a cross-sectional analysis, we selected women aged 15–50 years registered in the national ATHENA cohort and diagnosed with HIV in the Netherlands. Each pregnant woman with HIV was matched by year of pregnancy to three pregnant women without HIV from the general population using non-public registry data from Statistics Netherlands. Characteristics were examined using multivariable logistic regression.

RESULTS

Ninety-two of 523 women with HIV were diagnosed during pregnancy. These women less often had an advanced HIV infection than non-pregnant women with HIV (22 vs. 47%). Eighty-three of 92 pregnant women with HIV were matched with 249 pregnant women without HIV. Being diagnosed during pregnancy was associated with first- (aOR: 14.1; 95% CI: 6.45–30.6) or second-generation migration background (aOR: 5.38; 95% CI:2.02–11.0), income below the poverty line (aOR: 3.46; 95% CI: 1.28–9.34) and living in a single-parent household (aOR: 3.46; 95% CI: 1.52–7.88).

CONCLUSION

Antenatal HIV diagnoses accounted for a substantial part of diagnoses among women; pregnant women were less likely to present with advanced-stage disease. These findings show the importance of universal antenatal HIV screening.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2026.31.37.2600048
2026-09-17
2026-10-14
/content/10.2807/1560-7917.ES.2026.31.37.2600048
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/31/37/eurosurv-31-37-3.html?itemId=/content/10.2807/1560-7917.ES.2026.31.37.2600048&mimeType=html&fmt=ahah

References

  1. Joint United Nations Programme on HIV/AIDS (UNAIDS). Global report: UNAIDS report on the global AIDS epidemic 2012. Geneva: UNAIDS; 2012. Available from: https://www.unaids.org/en/resources/documents/2012/20121120_UNAIDS_Global_Report_2012
  2. De Cock KM, Fowler MG, Mercier E, de Vincenzi I, Saba J, Hoff E, et al. Prevention of mother-to-child HIV transmission in resource-poor countries: translating research into policy and practice. JAMA. 2000;283(9):1175-82.  https://doi.org/10.1001/jama.283.9.1175  PMID: 10703780 
  3. Cooper ER, Charurat M, Mofenson L, Hanson IC, Pitt J, Diaz C, et al. Combination antiretroviral strategies for the treatment of pregnant HIV-1-infected women and prevention of perinatal HIV-1 transmission. J Acquir Immune Defic Syndr. 2002;29(5):484-94.  https://doi.org/10.1097/00042560-200204150-00009  PMID: 11981365 
  4. Boer K, Nellen JF, Patel D, Timmermans S, Tempelman C, Wibaut M, et al. The AmRo study: pregnancy outcome in HIV-1-infected women under effective highly active antiretroviral therapy and a policy of vaginal delivery. BJOG. 2007;114(2):148-55.  https://doi.org/10.1111/j.1471-0528.2006.01183.x  PMID: 17305888 
  5. European Centre for Disease Prevention and Control (ECDC). Antenatal screening for HIV, hepatitis B, syphilis and rubella susceptibility in the EU/EEA. Stockholm: ECDC; 2016. Available from: https://www.ecdc.europa.eu/en/publications-data/antenatal-screening-hiv-hepatitis-b-syphilis-and-rubella-susceptibility-eueea
  6. van Sighem AI, Wit FWNM, Smit C, Jongen VW, Shalev N, Blomaard C. HIV monitoring Report 2025. Human Immunodeficiency Virus (HIV) Infection in the Netherlands. Amsterdam: Stichting HIV monitoring; 2025. Available from: https://www.hiv-monitoring.nl/nl/resources/monitoring-report-2025
  7. Op de Coul ELM, Hahné S, van Weert YWM, Oomen P, Smit C, van der Ploeg KPB, et al. Antenatal screening for HIV, hepatitis B and syphilis in the Netherlands is effective. BMC Infect Dis. 2011;11(1):185.  https://doi.org/10.1186/1471-2334-11-185  PMID: 21718466 
  8. Mulder-Folkerts DKF, van den Hoek JAR, van der Bij AK, Boer K, Schutte MF, Coutinho RA. Minder weigering van deelname aan HIV-screening door zwangeren in Amsterdam sedert de invoering van de standaard-HIV-screening--tenzij weigering (‘opting-out’-methode). [Less refusal to participate in HIV screening among pregnant women in the Amsterdam region since the introduction of standard HIV screening using the opting-out method]. Ned Tijdschr Geneeskd. 2004;148(41):2035-7. PMID: 15554003 
  9. van der Ploeg CPB, Odijk JAM, van Lent M. Prenatale Screening Infectieziekten en Erytrocytenimmunisatie (PSIE) 2023. [Antenatal screening for infectious diseases and erythrocytes immunisation 2023]. RIVM; 2024. Dutch. Available from: https://www.pns.nl/documenten/proces-monitor-psie-2023
  10. van der Ploeg CPB, Odijk JAM, van Lent M. Prenatale Screening Infectieziekten en Erytrocytenimmunisatie (PSIE) 2022. [Antenatal screening for infectious diseases and erythrocytes immunisation 2022]. Amsterdam: RIVM; 2024. Dutch. Available from: https://www.pns.nl/documenten/proces-monitor-psie-2022
  11. Byrne L, Short C-E, Bamford A, Bradshaw D, Cheserem E, Clarke E, et al. BHIVA guidelines on the management of HIV in pregnancy and the postpartum period 2025. HIV Med. 2025;26(11):1757-880.  https://doi.org/10.1111/hiv.70091  PMID: 41201115 
  12. Boender TS, Smit C, Sighem AV, Bezemer D, Ester CJ, Zaheri S, et al. AIDS Therapy Evaluation in the Netherlands (ATHENA) national observational HIV cohort: cohort profile. BMJ Open. 2018;8(9):e022516.  https://doi.org/10.1136/bmjopen-2018-022516  PMID: 30249631 
  13. Uitvoeringsinstituut Werknemersverzekeringen (UWV). Sociaal minimum. [Social minimum]. Amsterdam: UWV. [Accessed: 21 Nov 2024]. Dutch. Available from: https://www.uwv.nl/nl/toeslag/sociaal-minimum
  14. Mandelbrot L, Tubiana R, Le Chenadec J, Dollfus C, Faye A, Pannier E, et al. No perinatal HIV-1 transmission from women with effective antiretroviral therapy starting before conception. Clin Infect Dis. 2015;61(11):1715-25.  https://doi.org/10.1093/cid/civ578  PMID: 26197844 
  15. Wijstma E, Jongen VW, Boyd A, de Vries HJC, Schim van der Loeff MF, Prins M, et al. Outcomes of a policy to prioritize populations with expected healthcare barriers for subsidized preexposure prophylaxis care in Amsterdam, the Netherlands. AIDS. 2025;39(1):75-84.  https://doi.org/10.1097/QAD.0000000000004027  PMID: 39352137 
  16. Dhairyawan R, Creighton S, Sivyour L, Anderson J. Testing the fathers: carrying out HIV and STI tests on partners of pregnant women. Sex Transm Infect. 2012;88(3):184-6.  https://doi.org/10.1136/sextrans-2011-050232  PMID: 22199134 
  17. Clinical Info HIV.gov. Recommendations for the Use of Antiretroviral Drugs During Pregnancy and Interventions to Reduce Perinatal HIV Transmission in the United States. Rockville: Clinical Info HIV.gov. [Accessed: 12 Jun 2025]. Available from: https://clinicalinfo.hiv.gov/en/guidelines/perinatal/whats-new
  18. Creighton S, Badham E, Stacey L, Reeves I. HIV testing in termination of pregnancy services. Sex Transm Infect. 2012;88(1):69.  https://doi.org/10.1136/sextrans-2011-050210  PMID: 22123162 
  19. Filippidis P, Francini K, Jacot-Guillarmod M, Mathevet P, Lhopitallier L, Cavassini M, et al. HIV testing in termination of pregnancy and colposcopy services: a scoping review. Sex Transm Infect. 2022;98(2):143-9.  https://doi.org/10.1136/sextrans-2021-055111  PMID: 34544889 
  20. European Centre for Disease Prevention and Control (ECDC). Antenatal screening approaches effective in preventing mother-child-transmission of HIV, hepatitis B, syphilis and rubella in vulnerable populations. Stockholm: ECDC; 21 Mar 2017. Available from: https://www.ecdc.europa.eu/en/publications-data/antenatal-screening-approaches-effective-preventing-mtct-hiv-hbv-syphilis-and
  21. Wu S, Wang J, Guo Q, Lan H, Sun Y, Ren M, et al. Prevalence of human immunodeficiency virus, syphilis, and hepatitis B and C virus infections in pregnant women: a systematic review and meta-analysis. Clin Microbiol Infect. 2023;29(8):1000-7.  https://doi.org/10.1016/j.cmi.2023.03.002  PMID: 36921717 
  22. Shoemaker ES, Volpini K, Smith S, Loutfy M, Kendall C. Equitable Timing of HIV Diagnosis Prior to Pregnancy: A Canadian Perspective. Cureus. 2021;13(7):e16691.  https://doi.org/10.7759/cureus.16691  PMID: 34466322 
  23. Favarato G, Bailey H, Burns F, Prieto L, Soriano-Arandes A, Thorne C. Migrant women living with HIV in Europe: are they facing inequalities in the prevention of mother-to-child-transmission of HIV? The European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) study group in EuroCoord. Eur J Public Health. 2018;28(1):55-60.  https://doi.org/10.1093/eurpub/ckx048  PMID: 28449111 
  24. Gueler A, Schoeni-Affolter F, Moser A, Bertisch B, Bucher HC, Calmy A, et al. Neighbourhood socio-economic position, late presentation and outcomes in people living with HIV in Switzerland. AIDS. 2015;29(2):231-8.  https://doi.org/10.1097/QAD.0000000000000524  PMID: 25396262 
  25. Dasgupta S, McManus T, Tie Y, Lin CY, Yuan X, Sharpe JD, et al. Comparison of Demographic Characteristics and Social Determinants of Health Between Adults With Diagnosed HIV and All Adults in the U.S. AJPM Focus. 2023;2(3):100115.  https://doi.org/10.1016/j.focus.2023.100115  PMID: 37790662 
  26. Jongen VW, Boyd A, Albers T, Schat N, Verhagen M, van Zoest R, et al. Harnessing registry data to identify socio-demographic and socio-economic gaps in HIV care in the Netherlands. Nat Commun. 2025;16(1):10517.  https://doi.org/10.1038/s41467-025-65512-6  PMID: 41298373 
  27. Heffron R, Donnell D, Kiarie J, Rees H, Ngure K, Mugo N, et al. A prospective study of the effect of pregnancy on CD4 counts and plasma HIV-1 RNA concentrations of antiretroviral-naive HIV-1-infected women. J Acquir Immune Defic Syndr. 2014;65(2):231-6.  https://doi.org/10.1097/QAI.0000000000000013  PMID: 24442226 
/content/10.2807/1560-7917.ES.2026.31.37.2600048
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error