Emergence of carbapenemase-producing Enterobacteriaceae in France, 2004 to 2011

S Vaux; A Carbonne; J M Thiolet; V Jarlier; B Coignard; Collective RAISIN and Expert Laboratories Groups

doi:10.2807/ese.16.22.19880-en

Surveillance and outbreak reports Open Access

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Emergence of carbapenemase-producing Enterobacteriaceae in France, 2004 to 2011

S Vaux¹, A Carbonne², J M Thiolet¹, V Jarlier³, B Coignard¹, Collective RAISIN and Expert Laboratories Groups⁴
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Affiliations: ¹ French Institute for Public Health Surveillance (Institut de Veille Sanitaire, InVS), Saint-Maurice, France ² Centre de coordination de la lutte contre les infections nosocomiales (CClin) Nord, Paris, France ³ Pierre et Marie Curie (Paris 6) University (EA1541), Paris, France ⁴ The participants of these groups are listed at the end of the article

Correspondence:
B Coignard
b.coignard invs.sante.fr
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Citation style for this article: Vaux S, Carbonne A, Thiolet J M, Jarlier V, Coignard B, RAISIN and Expert Laboratories Groups Collective. Emergence of carbapenemase-producing Enterobacteriaceae in France, 2004 to 2011 . Euro Surveill. 2011;16(22):pii=19880. https://doi.org/10.2807/ese.16.22.19880-en Received: 17 Dec 2010

Abstract

Emergence of carbapenemase-producing Enterobacteriaceae (CPE) is currently a major public health concern worldwide. This study showed that 53 episodes of CPE infection or colonisation have been notified by French healthcare facilities since 2004. A sharp increase in the number of notifications was observed in the last three years. Oxacillinase (OXA)-48 and Klebsiella pneumoniae carbapenemase (KPC) beta-lactamases were the most frequent enzymes reported in these episodes. The index cases in most episodes were patients with a history of hospitalisation abroad within the previous year. Around a third of the episodes (n=18) led to secondary transmission in hospitals but most of them were controlled due to reinforced measures. Reinforcement of screening and control measures at national level when there is cross-border transfer of patients, along with overall reinforcement of infection control and antimicrobial stewardship worldwide, is urgently needed to contain the spread of CPE.