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Sexually transmitted infections (STIs): epidemiological trends and resistance

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Sexually transmitted infections (STIs): epidemiological trends and resistance

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- Multidrug-resistant Neisseria gonorrhoeae failing treatment with ceftriaxone and doxycycline in France, November 2017
  
  Thibault Poncin , Sebastien Fouere , Aymeric Braille , Francois Camelena , Myriem Agsous , Cecile Bebear , Sylvain Kumanski , Florence Lot , Severine Mercier-Delarue , Ndeindo Ndeikoundam Ngangro , Maud Salmona , Nathalie Schnepf , Julie Timsit , Magnus Unemo and Beatrice Bercot
  
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  We report a multidrug-resistant Neisseria gonorrhoeae urogenital and pharyngeal infection with ceftriaxone resistance and intermediate resistance to azithromycin in a heterosexual woman in her 20s in France. Treatment with ceftriaxone plus doxycycline failed for the pharyngeal localisation. Whole-genome sequencing of isolate F90 identified MLST1903, NG-MAST ST3435, NG-STAR233, and relevant resistance determinants. F90 showed phenotypic and genotypic similarities to an internationally spreading multidrug-resistant and ceftriaxone-resistant clone detected in Japan and subsequently in Australia, Canada and Denmark.
  
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