Table 2

Ranking of selected infectious diseases according to annual DALYs per 100,000 population, EU/EEA countries, 2009–2013

Infectious disease Median (95% uncertainty interval)a % of total DALYs
Incidence per 100,000 population Deaths per 100,000 population DALYs per case YLD per 100,000 population YLL per 100,000 population DALY per 100,000 population
Influenza 5,887 (5,544–6,223) 5.89 (5.54–6.22) 0.01 5.42 (4.73–6.16) 76.3 (71.9–80.7) 81.8 (76.9–86.5) 29.8
Tuberculosis 14.9 (14.7–15.2) 1.10 (1.08–1.12) 3.58 (3.55–3.62) 9.20 (8.98–9.43) 44.3 (43.5–45.1) 53.5 (52.5–54.4) 19.5
Human immunodeficiency virus infection 7.99 (7.44–8.55) 0.15 (0.13–0.16) 6.03 (5.86–6.20) 43.1 (39.7–46.4) 5.13 (4.53–5.64) 48.2 (44.5–51.9) 17.5
Invasive pneumococcal disease 11.0 (10.7–11.2) 1.18 (1.15–1.21) 2.74 (2.71–2.77) 2.49 (2.25–2.73) 27.6 (26.9–28.2) 30.1 (29.3–30.8) 10.9
Legionnaires’ disease 3.40 (2.77–4.01) 0.37 (0.30–0.45) 3.04 (2.73–3.36) 0.02 (0.02–0.03) 10.3 (8.21–12.4) 10.3 (8.23–12.4) 3.75
Campylobacteriosis 654 (599–707) 0.18 (0.13–0.23) 0.01 3.25 (2.73–3.87) 5.03 (3.59–6.58) 8.28 (6.68–10.0) 3.01
Hepatitis B 2.84 (2.29–3.40) 0.15 (0.09–0.21) 2.79 (1.46–4.45) 0.49 (0.30–0.72) 7.37 (3.85–11.7) 7.86 (4.19–12.2) 2.86
Invasive disease 1.52 (1.51–1.53) 0.17 3.43 (3.39–3.47) 0.28 (0.24–0.31) 4.94 (4.88–5.00) 5.22 (5.15–5.29) 1.90
Invasive meningococcal disease 0.85 (0.83–0.86) 0.07 5.64 (5.59–5.70) 0.39 (0.35–0.44) 4.39 (4.31–4.48) 4.78 (4.68–4.88) 1.74
Chlamydia infection 186 (124–259)  < 0.01 0.02 (0.01–0.05) 4.62 (2.16–9.0) Negligible 4.63 (2.16–9.03) 1.68
Salmonellosis 211 (208–214) 0.16 (0.15–0.17) 0.02 0.86 (0.74–1.01) 3.11 (2.85–3.36) 3.97 (3.68–4.25) 1.44
Pertussis 263 (211–317) 0.02 0.01 2.04 (1.59–2.56) 1.28 (1.14–1.45) 3.33 (2.78–3.94) 1.21
Shiga toxin/verocytotoxin-producing Escherichia coli (STEC/VTEC) infection 48.1 (36.2–59.4) 0.05 (0.04–0.07) 0.05 (0.05–0.06) 0.62 (0.49–0.76) 1.98 (1.56–2.44) 2.59 (2.05–3.21) 0.94
Listeriosis 0.56 (0.52–0.59) 0.08 (0.08–0.09) 3.65 (3.52–3.79) 0.20 (0.15–0.25) 1.84 (1.74–1.94) 2.04 (1.92–2.16) 0.74
Rubella 51.6  < 0.01 0.02 (0.01–0.02) 0.55 (0.39–0.74) 0.37 (0.29–0.45) 0.92 (0.71–1.15) 0.33
Gonorrhoea 34.2 (24.4–44.2)  < 0.01 0.02 (0.01–0.04) 0.77 (0.49–1.24) 0.01 (0.01–0.02) 0.78 (0.50–1.26) 0.28
Hepatitis A 10.0 (9.67–10.4) 0.02 0.07 (0.06–0.08) 0.14 (0.11–0.17) 0.58 (0.51–0.66) 0.72 (0.64–0.80) 0.26
Tick-borne encephalitis 3.00 (2.87–3.13)  < 0.01 0.23 (0.22–0.24) 0.46 (0.43–0.49) 0.23 (0.22–0.25) 0.69 (0.65–0.74) 0.25
Shigellosis 27.0 (23.4–30.7) 0.01 (0.01–0.02) 0.03 (0.02–0.03) 0.09 (0.08–0.11) 0.59 (0.41–0.82) 0.68 (0.49–0.93) 0.25
Measles 7.46  < 0.01 0.08 (0.07–0.08) 0.14 (0.11–0.17) 0.42 (0.38–0.46) 0.56 (0.51–0.61) 0.20
Congenital toxoplasmosis 0.19 (0.11–0.28)  < 0.01 2.42 (1.92–3.05) 0.34 (0.17–0.56) 0.12 (0.06–0.19) 0.46 (0.24–0.73) 0.17
Giardiasis 88.9 (75.0–104)  < 0.01  < 0.01 0.36 (0.30–0.43) 0.05 (0.04–0.06) 0.41 (0.34–0.48) 0.15
Q fever 1.58  < 0.01 0.20 (0.16–0.23)  < 0.01 0.31 (0.25–0.36) 0.31 (0.26–0.37) 0.11
Tetanus 0.06 (0.05–0.07)  < 0.01 2.02 (1.91–2.15)  < 0.01 0.12 (0.11–0.13) 0.12 (0.11–0.13) 0.04
Mumps 24.2 (22.6–25.8)  < 0.01  < 0.01 0.07 (0.06–0.07) 0.02 0.09 (0.08–0.10) 0.03
Cryptosporidiosis 34.7 (32.3–37.1)  < 0.01  < 0.01 0.03 (0.02–0.03) 0.06 (0.05–0.06) 0.08 (0.08–0.09) 0.03
Syphilis 2.04 (1.68–2.38)  < 0.01 0.04 (0.04–0.05) 0.04 (0.03–0.04) 0.05 0.08 (0.08–0.09) 0.03
variant Creutzfeldt–Jakob disease  < 0.01  < 0.01 48.6 (48.4–48.8)  < 0.01 0.04 0.04 0.01
Diphtheria 0.02  < 0.01 1.16  < 0.01 0.02 0.02 0.01
Rabies  < 0.01  < 0.01 52.1  < 0.01 0.01 0.01  < 0.01

DALYs: disability-adjusted life years; EU/EEA: European Union/European Economic Area; YLD: years lived with disability: YLL: years of life lost; NA: not applicable.

a Median and 95% uncertainty interval as estimated from the Burden of Communicable Diseases in Europe (BCoDE) toolkit (10,000 Monte Carlo simulations).

Values < 0.01 are not specified. Uncertainties that deviate less than 0.01 from the median are not specified.