Table 1

Adjusted incidence rate ratios of SARS-CoV-2 reinfection, Italy, 24 August 2021–6 March 2022 (n =249,121)

Reinfection

(249,121)
PD

(842,254,906)
Incidence per 100,000 PD RR adjusted

(95% CI)
p value
Epidemic phasea Delta 6,028 434,476,324 1.39 Reference
Transition 36,509 124,883,250 29.23 8.79 (8.45–9.13) < 0.001
Omicron 206,584 282,895,332 73.02 18.09 (17.43–18.77) < 0.001
Days from first diagnosis 90–210 25,126 147,300,836 17.06 Reference
210–330 67,149 319,935,680 20.99 1.51 (1.47–1.56) < 0.001
330–450 121,934 284,817,183 42.81 1.73 (1.69–1.79) < 0.001
> 450 34,912 90,201,207 38.70 1.67 (1.62–1.72) < 0.001
Vaccination status Vaccinated with at least one dose for ≤ 120 days 81,235 408,702,801 19.88 Reference
Vaccinated with at least one dose for > 120 days 77,829 216,463,056 35.95 1.53 (1.5–1.57) < 0.001
Unvaccinated 90,057 217,089,049 41.48 2.90 (2.83–2.97) < 0.001
Sex Male 112,804 410,792,861 27.46 Reference
Female 136,317 431,462,045 31.59 1.20 (1.18–1.22) < 0.001
Age group (years) 0–19 51,212 129,028,476 39.69 1.03 (1.00–1.06) 0.0806
20–39 82,037 211,577,554 38.77 1.22 (1.19–1.25) < 0.001
40–59 85,978 283,687,021 30.31 Reference
60–79 21,268 160,343,346 13.26 0.47 (0.46–0.49) < 0.001
≥ 80 8,626 57,618,509 14.97 0.43 (0.41–0.45) < 0.001
Nationality Italian 227,273 767,676,929 29.61 Reference
Foreign 21,848 74,577,977 29.30 0.60 (0.58–0.61) < 0.001
Healthcare worker No 236,178 815,250,169 28.97 Reference
Yes 12,943 27,004,737 47.93 1.90 (1.84–1.96) < 0.001

CI: confidence interval; IRR: incidence rate ratios; PD: person-days; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2.

a Epidemic phases: Delta: 24 Aug–5 Dec 2021; transition: 6 Dec 2021–2 Jan 2022; Omicron: 3 Jan–6 Mar 2022.