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Abstract

Background: Lyme borreliosis (LB) is the most frequent vector-borne disease in France. Since 2009, surveillance of LB is conducted by a sentinel network of general practitioners (GPs). This system, in conjunction with the national hospitalisation database was used to estimate the incidence and describe the characteristics of LB in France.

Aim: To describe the estimated incidence and trends in GP consultations and hospital admissions for LB in France and identify risk groups and high-incidence regions.

Results: From 2011 to 2016, the mean yearly incidence rate of LB cases was 53 per 100,000 inhabitants (95% CI: 41–65) ranging from 41 in 2011 to 84 per 100 000 in 2016. A mean of 799 cases per year were hospitalised with LB associated diagnoses 2005–16. The hospitalisation incidence rate (HIR) ranged from 1.1 cases per 100,000 inhabitants in 2005 to 1.5 in 2011 with no statistically significant trend. We observed seasonality with a peak during the summer, important inter-regional variations and a bimodal age distribution in LB incidence and HIR with higher incidence between 5 and 9 year olds and those aged 60 years. Erythema migrans affected 633/667 (95%) of the patients at primary care level. Among hospitalised cases, the most common manifestation was neuroborreliosis 4,906/9,594 (51%).

Conclusion: Public health strategies should focus on high-incidence age groups and regions during the months with the highest incidences and should emphasise prevention measures such as regular tick checks after exposure and prompt removal to avoid infection.

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/content/10.2807/1560-7917.ES.2019.24.11.1800134
2019-03-14
2024-04-19
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2019.24.11.1800134
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References

  1. Stanek G, Wormser GP, Gray J, Strle F. Lyme borreliosis. Lancet. 2012;379(9814):461-73.  https://doi.org/10.1016/S0140-6736(11)60103-7  PMID: 21903253 
  2. Bacon RM, Kugeler KJ, Mead PSCenters for Disease Control and Prevention (CDC). Surveillance for Lyme disease--United States, 1992-2006. MMWR Surveill Summ. 2008;57(10):1-9. PMID: 18830214 
  3. Applegren ND, Kraus CK. Lyme Disease: Emergency Department Considerations. J Emerg Med. 2017;52(6):815-24.  https://doi.org/10.1016/j.jemermed.2017.01.022  PMID: 28291638 
  4. Rizzoli A, Hauffe H, Carpi G, Vourc H G, Neteler M, Rosa R. Lyme borreliosis in Europe. Euro Surveill. 2011;16(27):19906. PMID: 21794218 
  5. Sykes RA, Makiello P. An estimate of Lyme borreliosis incidence in Western Europe. J Public Health (Oxf). 2017;39(1):74-81. PMID: 26966194 
  6. Sprong H, Hofhuis A, Gassner F, Takken W, Jacobs F, van Vliet AJ, et al. Circumstantial evidence for an increase in the total number and activity of Borrelia-infected Ixodes ricinus in the Netherlands. Parasit Vectors. 2012;5(1):294.  https://doi.org/10.1186/1756-3305-5-294  PMID: 23244453 
  7. Hofhuis A, van der Giessen JW, Borgsteede FH, Wielinga PR, Notermans DW, van Pelt W. Lyme borreliosis in the Netherlands: strong increase in GP consultations and hospital admissions in past 10 years. Euro Surveill. 2006;11(6):E060622.2. PMID: 16819128 
  8. Dubrey SW, Bhatia A, Woodham S, Rakowicz W. Lyme disease in the United Kingdom. Postgrad Med J. 2014;90(1059):33-42.  https://doi.org/10.1136/postgradmedj-2012-131522  PMID: 24198341 
  9. Trájer A, Bobvos J, Páldy A, Krisztalovics K. Association between incidence of Lyme disease and spring-early summer season temperature changes in Hungary--1998-2010. Ann Agric Environ Med. 2013;20(2):245-51. PMID: 23772569 
  10. Bennet L, Halling A, Berglund J. Increased incidence of Lyme borreliosis in southern Sweden following mild winters and during warm, humid summers. Eur J Clin Microbiol Infect Dis. 2006;25(7):426-32.  https://doi.org/10.1007/s10096-006-0167-2  PMID: 16810531 
  11. Fülöp B, Poggensee G. Epidemiological situation of Lyme borreliosis in Germany: surveillance data from six Eastern German States, 2002 to 2006. Parasitol Res. 2008;103(S1) Suppl 1;S117-20.  https://doi.org/10.1007/s00436-008-1060-y  PMID: 19030893 
  12. Wilking H, Stark K. Trends in surveillance data of human Lyme borreliosis from six federal states in eastern Germany, 2009-2012. Ticks Tick Borne Dis. 2014;5(3):219-24.  https://doi.org/10.1016/j.ttbdis.2013.10.010  PMID: 24656810 
  13. Hayes EB, Piesman J. How can we prevent Lyme disease? N Engl J Med. 2003;348(24):2424-30.  https://doi.org/10.1056/NEJMra021397  PMID: 12802029 
  14. Vandenesch A, Turbelin C, Couturier E, Arena C, Jaulhac B, Ferquel E, et al. Incidence and hospitalisation rates of Lyme borreliosis, France, 2004 to 2012. Euro Surveill. 2014;19(34):20883.  https://doi.org/10.2807/1560-7917.ES2014.19.34.20883  PMID: 25188613 
  15. Sante publique France. Données épidémiologiques Borreliose de Lyme. [Data and surveillance. Lyme Borreliosis]. Paris: Sante publique France; [Accessed: 2 Mar 2019]. French. Available from: http://invs.santepubliquefrance.fr/Dossiers-hematiques/Maladies-infectieuses/Maladies-a-transmission-vectorielle/Borreliose-de-lyme/Donnees-epidemiologiques
  16. Flahault A, Blanchon T, Dorléans Y, Toubiana L, Vibert JF, Valleron AJ. Virtual surveillance of communicable diseases: a 20-year experience in France. Stat Methods Med Res. 2006;15(5):413-21.  https://doi.org/10.1177/0962280206071639  PMID: 17089946 
  17. Souty C, Turbelin C, Blanchon T, Hanslik T, Le Strat Y, Boëlle PY. Improving disease incidence estimates in primary care surveillance systems. Popul Health Metr. 2014;12(1):19.  https://doi.org/10.1186/s12963-014-0019-8  PMID: 25435814 
  18. Stanek G, Fingerle V, Hunfeld KP, Jaulhac B, Kaiser R, Krause A, et al. Lyme borreliosis: clinical case definitions for diagnosis and management in Europe. Clin Microbiol Infect. 2011;17(1):69-79.  https://doi.org/10.1111/j.1469-0691.2010.03175.x  PMID: 20132258 
  19. Instit national de la statistique et des études éconmiques (INSEE). Evolution et structure de la population. [Population structure and its evolution]. Paris: INSEE; 2019. French. Available from: https://www.insee.fr/fr/statistiques/1893198
  20. Boudemaghe T, Belhadj I. Data Resource Profile: The French National Uniform Hospital Discharge Data Set Database (PMSI). Int J Epidemiol. 2017;46(2):392-392d.  https://doi.org/10.1093/ije/dyw359  PMID: 28168290 
  21. World Health Organization (WHO). International statistical classification of diseases and related health problems. 10th Revision. Volume 3. Fifth edition. Geneva: WHO; 2016. Available from: https://icd.who.int/browse10/2016/en
  22. Gueorguiev Penev D, Laurent E, Baron S, Diot E, Bastides F, de Gialluly C, et al. Borréliose de Lyme : recensement des cas adultes hospitalisés en Indre-et-Loire, à partir du PMSI (1999–2006) [Lyme borreliosis: census of adult patients hospitalized in Indre-et-Loire (France), from the Hospital Discharge Data (1999-2006)]. Rev Epidemiol Sante Publique. 2010;58(5):339-47.  https://doi.org/10.1016/j.respe.2010.05.003  PMID: 20708866 
  23. Bleyenheuft C, Lernout T, Berger N, Rebolledo J, Leroy M, Robert A, et al. Epidemiological situation of Lyme borreliosis in Belgium, 2003 to 2012. Arch Public Health. 2015;73(1):33.  https://doi.org/10.1186/s13690-015-0079-7  PMID: 26146553 
  24. Hofhuis A, Bennema S, Harms M, van Vliet AJ, Takken W, van den Wijngaard CC, et al. Decrease in tick bite consultations and stabilization of early Lyme borreliosis in the Netherlands in 2014 after 15 years of continuous increase. BMC Public Health. 2016;16(1):425.  https://doi.org/10.1186/s12889-016-3105-y  PMID: 27216719 
  25. Sajanti E, Vrtanen M, Helve O, Kuusi M, Lvvtikäinen O. Hvtönen, Sane Jussi. Lyme borreliosis in Finland, 1995-2014: a nationwide register-based study. Poster presentation at the European Scientific Conference on Applied Infectious Disease Epidemiology (ESCAIDE), 28-30 November 2016, Stockholm.
  26. Altpeter E, Zimmermann H, Oberreich J, Péter O, Dvořák C, Swiss S. Tick related diseases in Switzerland, 2008 to 2011. Swiss Med Wkly. 2013;143:w13725.  https://doi.org/10.4414/smw.2013.13725  PMID: 23299974 
  27. Enkelmann J, Böhmer M, Fingerle V, Siffczyk C, Werber D, Littmann M, et al. Incidence of notified Lyme borreliosis in Germany, 2013-2017. Sci Rep. 2018;8(1):14976.  https://doi.org/10.1038/s41598-018-33136-0  PMID: 30297731 
  28. Vandererven C, Bellanger AP, Faucher JF, Marguet P. Primary care physician management of tick bites in the Franche-Comté region (Eastern France, 2013). Med Mal Infect. 2017;47(4):261-5.  https://doi.org/10.1016/j.medmal.2017.03.007  PMID: 28457701 
  29. Institut scientifique de Santé publique (WIV-ISP). Zoonoses et Maladies à Transmission Vectorielle. [Zoonoses and vector borne diseases]. Brussels: WIV-ISP; 2017. French. Available from: https://epidemio.wiv-isp.be/ID/reports/Zoonoses%20et%20maladies%20%C3%A0%20transmission%20vectorielle.%20Rapport%20annuel%202015%20et%202016.pdf
  30. Vanthomme K, Bossuyt N, Boffin N, Van Casteren V. Incidence and management of presumption of Lyme borreliosis in Belgium: recent data from the sentinel network of general practitioners. Eur J Clin Microbiol Infect Dis. 2012;31(9):2385-90.  https://doi.org/10.1007/s10096-012-1580-3  PMID: 22391757 
  31. Lindgren E, Jaenson TGT. Lyme Borreliosis in Europe: Influences of Climate and Climate Change, Epidemiology, Ecology and Adaptation Measures (report no.: EUR/04/5046250). Copenhagen: World Health Organization; 2006. Available from: http://www.euro.who.int/__data/assets/pdf_file/0006/96819/E89522.pdf
  32. Ministère des affaires sociales et de la santé. Plan national de lutte contre la maladie de Lyme et les maladies transmissibles par les tiques 2016. [National Plan against Lyme disease and tick-borne diseases 2016]. Paris: Ministère des affaires sociales et de la santé; 2016. French. Available from: https://solidarites-sante.gouv.fr/IMG/pdf/plan_lyme_281216_aes_-_2.pdf
  33. Meteo France. Bilan climatique de l'année 2016. Météo France. [Climate report. Annual 2016. France]. Paris: Meteo France; 2016. French. Available from: http://www.meteofrance.fr/climat-passe-et-futur/bilans-climatiques/bilan-2016/bilan-climatique-de-l-annee-2016
  34. Lohr B, Müller I, Mai M, Norris DE, Schöffski O, Hunfeld KP. Epidemiology and cost of hospital care for Lyme borreliosis in Germany: lessons from a health care utilization database analysis. Ticks Tick Borne Dis. 2015;6(1):56-62.  https://doi.org/10.1016/j.ttbdis.2014.09.004  PMID: 25448420 
  35. Dahl V, Tegmark-Wisell K, Tegnell A, Wallensten A. The national hospital discharge diagnosis registry is the most suitable data source for surveillance of Lyme borreliosis in Sweden. Poster presentation at the European Scientific Conference on Applied Infectious Disease Epidemiology (ESCAIDE), 11-13 November 2015, Stockholm.
  36. Claudine Pérez‐Eid. Les tiques. Identification, biologie, importance médicale et vétérinaire. [Ticks - Identification, biology, medical and veterinary importance]. Monographie de microbiologie, Tec & Doc EMinter‐Lavoisier ; 2007. Available from: https://www.unitheque.com/Livre/tec_et_doc_-_em_inter_-_lavoisier/Monographies_de_microbiologie/Les_tiques-12028.html
  37. European Centre for Disease Prevention and Control (ECDC). Ixodes ricinus - current known distribution: October 2017. Stockholm: ECDC; 2017. Available from: https://ecdc.europa.eu/en/publications-data/ixodes-ricinus-current-known-distribution-october-2017
  38. Medlock JM, Hansford KM, Bormane A, Derdakova M, Estrada-Peña A, George JC, et al. Driving forces for changes in geographical distribution of Ixodes ricinus ticks in Europe. Parasit Vectors. 2013;6(1):1.  https://doi.org/10.1186/1756-3305-6-1  PMID: 23281838 
  39. van den Wijngaard CC, Hofhuis A, Simões M, Rood E, van Pelt W, Zeller H, et al. Surveillance perspective on Lyme borreliosis across the European Union and European Economic Area. Euro Surveill. 2017;22(27):30569.  https://doi.org/10.2807/1560-7917.ES.2017.22.27.30569  PMID: 28703098 
  40. Sante publique France – Dossier thématique Borreliose de Lyme. Saint-Maurice: Sante publique France; [Cited 2018]. French. Available from: http://invs.santepubliquefrance.fr/Dossiers-thematiques/Maladies-infectieuses/Maladies-a-transmission-vectorielle/Borreliose-de-lyme/Points-sur-les-connaissances
  41. Mygland A, Ljøstad U, Fingerle V, Rupprecht T, Schmutzhard E, Steiner IEuropean Federation of Neurological Societies. EFNS guidelines on the diagnosis and management of European Lyme neuroborreliosis. Eur J Neurol. 2010;17(1):8-16, e1-4.  https://doi.org/10.1111/j.1468-1331.2009.02862.x  PMID: 19930447 
  42. Fonteneau L, Le Meur N, Cohen-Akenine A, Pessel C, Brouard C, Delon F, et al. Apport des bases médico-administratives en épidémiologie et santé publique des maladies infectieuses [The use of administrative health databases in infectious disease epidemiology and public health]. Rev Epidemiol Sante Publique. 2017;65(Suppl 4):S174-82.  https://doi.org/10.1016/j.respe.2017.03.131  PMID: 28624133 
Epidemiology of Lyme borreliosis through two surveillance systems: the national Sentinelles GP network and the national hospital discharge database, France, 2005 to 2016
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=A+Septfons&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Septfons A</a>, <a href="/search?value1=T+Goronflot&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Goronflot T</a>, <a href="/search?value1=B+Jaulhac&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jaulhac B</a>, <a href="/search?value1=V+Roussel&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Roussel V</a>, <a href="/search?value1=S+De+Martino&option1=author&noRedirect=true" class="nonDisambigAuthorLink">De Martino S</a>, <a href="/search?value1=S+Guerreiro&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Guerreiro S</a>, <a href="/search?value1=T+Launay&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Launay T</a>, <a href="/search?value1=L+Fournier&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fournier L</a>, <a href="/search?value1=H+De+Valk&option1=author&noRedirect=true" class="nonDisambigAuthorLink">De Valk H</a>, <a href="/search?value1=J+Figoni&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Figoni J</a>, <a href="/search?value1=T+Blanchon&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Blanchon T</a>, <a href="/search?value1=E+Couturier&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Couturier E</a></span>. Epidemiology of Lyme borreliosis through two surveillance systems: the national Sentinelles GP network and the national hospital discharge database, France, 2005 to 2016. <a href="/content/ecdc">Euro Surveill.</a> 2019;24(11):pii=1800134. <a href="https://doi.org/10.2807/1560-7917.ES.2019.24.11.1800134" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2019.24.11.1800134</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 14 Mar 2018;&nbsp;&nbsp; <span class="generated">Accepted</span>: 29 Jan 2019 </span> </p>
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