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Home Eurosurveillance Weekly Release  2006: Volume 11/ Issue 26 Article 4
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Eurosurveillance, Volume 11, Issue 26, 29 June 2006

Citation style for this article: van Duijn C, Ruijs H, Timen A. Second probable case of vCJD in the Netherlands. Euro Surveill. 2006;11(26):pii=2991. Available online:

Second probable case of vCJD in the Netherlands

C van Duijn1, H Ruijs2, ATimen2 (

1National Surveillance of CJD, Erasmus MC, Rotterdam, The Netherlands
2Centre for Infectious Diseases, National Institute of Public Health and the Environment (RIVM), The Netherlands

A second probable case of variant Creutzfeldt-Jakob (vCJD) disease in a patient in the Netherlands was reported on 22 June 2006, by the National Institute of Public Health and the Environment (RIVM) [1].

The case was detected through national surveillance of CJD, which is coordinated at the Erasmus Medical Centre in Rotterdam. The probable diagnosis is based on magnetic resonance imaging and, clinical signs. The patient has no mutations associated with inherited CJD, and is homozygous for methionine at codon 129 of the prion protein gene. The diagnosis was reviewed by the United Kingdom’s National Creutzfeldt-Jakob Disease Surveillance Unit, which runs the European and Allied Countries Collaborative Study Group of CJD (EUROCJD,
Patient data was collected by the national public health service together with the CJD surveillance unit, and revealed no specific exposure risks. The patient has never donated or received blood or tissue and has not undergone surgical procedures with risk of infection with prions. The patient has never lived in or travelled to the United Kingdom. Contaminated meat products remain the only plausible source of infection. Bovine spongiform encephalopathy (BSE) has been diagnosed in 82 cows in the Netherlands since 1997, according to data from the Ministry of Agriculture, Nature and Food Quality. [2]

This report brings the total number of vCJD cases reported to EUROCJD from outside the UK by June 2006 to 31: 17 in France, 4 in the republic of Ireland, 2 each in the United States and the Netherlands, and 1 in each of Italy, Canada, Saudi Arabia, Japan, Portugal and Spain. Six of these 31 cases were in people who lived in the UK for more than 6 months between 1980 and 1996 [3].

  1. Rijksinstituut voor Volksgezondheid en Milieu (RIVM). Variant Creutzfeldt-Jakob vastgesteld bij tweede patiënt in Nederland. Press release, 22 June 2006. [in Dutch] (
  2. Ministerie van Landbouw, Natuur en Voedselkwaliteit. BSE-geval in Dinkelland. Press release, 3 March 2006. ( [accessed 28 June 2006]
  3. The European and Allied Countries Collaborative Study Group of CJD (EUROCJD). Variant Creutzfeldt-Jakob Disease. Current Data (June 2006). ( [accessed 28 June 2006]

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