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Abstract

represents a health concern for both humans and pigs. The characterisation of its subspecies is an important step improving the understanding of the epidemiology and the control of this pathogen. Ninety-two human strains were selected for a retrospective study. Subspecies determination by sequencing and IS/IS analysis showed that 98.9% of Belgian human strains belong to the subspecies (MAH). Some of these MAH strains present particular IS/IS profiles (absence of IS and false IS901 detection provoked by the presence of IS). In addition, 54 MAH strains isolated from submandibular lymph nodes of Belgian pigs with lymphadenitis were included in this study. Genotyping of human and porcine isolates was performed using multispacer sequence typing (MST). In total, 49 different MST types were identified among pig (n = 11) and human (n = 43) MA isolates, with only five shared by both hosts. Among these MST types, 34 were newly identified. Our findings demonstrate the extensive genetic diversity among MAH isolates. Some genotypes were more prevalent in human or pigs but no correlation was observed between MST type and place of residence or the farm of origin for human and porcine isolates respectively, suggesting an environmental source of infection.

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/content/10.2807/1560-7917.ES.2016.21.3.30111
2016-01-21
2024-04-19
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.3.30111
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Genotyping and strain distribution of Mycobacterium avium subspecies hominissuis isolated from humans and pigs in Belgium, 2011–2013
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Christelle+Vluggen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vluggen Christelle</a>, <a href="/search?value1=Karine+Soetaert&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Soetaert Karine</a>, <a href="/search?value1=Lucille+Duytschaever&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Duytschaever Lucille</a>, <a href="/search?value1=Joseph+Deno%C3%ABl&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Denoël Joseph</a>, <a href="/search?value1=Maryse+Fauville-Dufaux&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fauville-Dufaux Maryse</a>, <a href="/search?value1=Fran%C3%A7ois+Smeets&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Smeets François</a>, <a href="/search?value1=Nicolas+Bruffaerts&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bruffaerts Nicolas</a>, <a href="/search?value1=Kris+Huygen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Huygen Kris</a>, <a href="/search?value1=David+Fretin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fretin David</a>, <a href="/search?value1=Leen+Rigouts&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rigouts Leen</a>, <a href="/search?value1=Claude+Saegerman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Saegerman Claude</a>, <a href="/search?value1=Vanessa+Mathys&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mathys Vanessa</a></span>. Genotyping and strain distribution of Mycobacterium avium subspecies hominissuis isolated from humans and pigs in Belgium, 2011–2013. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(3):pii=30111. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.3.30111" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.3.30111</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 09 Dec 2014;&nbsp;&nbsp; <span class="generated">Accepted</span>: 05 Jul 2015 </span> </p>
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