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Abstract

Chikungunya fever is an acute febrile illness caused by the chikungunya virus (CHIKV), which is transmitted to humans by mosquitoes. Although chikungunya fever is rarely fatal, patients can experience debilitating symptoms that last from months to years. Here we comprehensively assess the global distribution of chikungunya and produce high-resolution maps, using an established modelling framework that combines a comprehensive occurrence database with bespoke environmental correlates, including up-to-date distribution maps. This enables estimation of the current total population-at-risk of CHIKV transmission and identification of areas where the virus may spread to in the future. We identified 94 countries with good evidence for current CHIKV presence and a set of countries in the New and Old World with potential for future CHIKV establishment, demonstrated by high environmental suitability for transmission and in some cases previous sporadic reports. presence was identified as one of the major contributing factors to CHIKV transmission but significant geographical heterogeneity exists. We estimated 1.3 billion people are living in areas at-risk of CHIKV transmission. These maps provide a baseline for identifying areas where prevention and control efforts should be prioritised and can be used to guide estimation of the global burden of CHIKV.

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/content/10.2807/1560-7917.ES.2016.21.20.30234
2016-05-19
2017-10-19
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.20.30234
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References

  1. Weaver SC, Lecuit M. Chikungunya virus and the global spread of a mosquito-borne disease. N Engl J Med. 2015;372(13):1231-9.  https://doi.org/10.1056/NEJMra1406035  PMID: 25806915 
  2. Ross RW. The Newala epidemic. III. The virus: isolation, pathogenic properties and relationship to the epidemic. J Hyg (Lond). 1956;54(2):177-91.  https://doi.org/10.1017/S0022172400044442  PMID: 13346078 
  3. Powers AM, Logue CH. Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirus. J Gen Virol. 2007;88(Pt 9):2363-77.  https://doi.org/10.1099/vir.0.82858-0  PMID: 17698645 
  4. Weaver SC. Arrival of chikungunya virus in the new world: prospects for spread and impact on public health. PLoS Negl Trop Dis. 2014;8(6):e2921.  https://doi.org/10.1371/journal.pntd.0002921  PMID: 24967777 
  5. Volk SM, Chen R, Tsetsarkin KA, Adams AP, Garcia TI, Sall AA, et al. Genome-scale phylogenetic analyses of chikungunya virus reveal independent emergences of recent epidemics and various evolutionary rates. J Virol. 2010;84(13):6497-504.  https://doi.org/10.1128/JVI.01603-09  PMID: 20410280 
  6. Staples JE, Breiman RF, Powers AM. Chikungunya fever: an epidemiological review of a re-emerging infectious disease. Clin Infect Dis. 2009;49(6):942-8.  https://doi.org/10.1086/605496  PMID: 19663604 
  7. Chahar HS, Bharaj P, Dar L, Guleria R, Kabra SK, Broor S. Co-infections with chikungunya virus and dengue virus in Delhi, India. Emerg Infect Dis. 2009;15(7):1077-80.  https://doi.org/10.3201/eid1507.080638  PMID: 19624923 
  8. Weaver SC. Arrival of chikungunya virus in the new world: prospects for spread and impact on public health. PLoS Negl Trop Dis. 2014;8(6):e2921.  https://doi.org/10.1371/journal.pntd.0002921  PMID: 24967777 
  9. Chang LJ, Dowd KA, Mendoza FH, Saunders JG, Sitar S, Plummer SH, et al. VRC 311 Study Team. Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a phase 1 dose-escalation trial. Lancet. 2014;384(9959):2046-52.  https://doi.org/10.1016/S0140-6736(14)61185-5  PMID: 25132507 
  10. Johansson MA. Chikungunya on the move. Trends Parasitol. 2015;31(2):43-5.  https://doi.org/10.1016/j.pt.2014.12.008  PMID: 25649340 
  11. Kraemer MUG, Hay SI, Pigott DM, Smith DL, Wint GRW, Golding N. Progress and Challenges in Infectious Disease Cartography. Trends Parasitol. 2016;32(1):19-29.  https://doi.org/10.1016/j.pt.2015.09.006  PMID: 26604163 
  12. Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature. 2013;496(7446):504-7.  https://doi.org/10.1038/nature12060  PMID: 23563266 
  13. Brady OJ, Gething PW, Bhatt S, Messina JP, Brownstein JS, Hoen AG, et al. Refining the global spatial limits of dengue virus transmission by evidence-based consensus. PLoS Negl Trop Dis. 2012;6(8):e1760.  https://doi.org/http://dx.doi.org/10.1371/journal.pntd.0001760 
  14. Messina JP, Kraemer MU, Brady OJ, Pigott DM, Shearer FM, Weiss DJ, et al. Mapping global environmental suitability for Zika virus. eLife. 2016;5:e15272.  https://doi.org/10.7554/eLife.15272  PMID: 27090089 
  15. Pigott DM, Bhatt S, Golding N, Duda KA, Battle KE, Brady OJ, et al. Global distribution maps of the leishmaniases. eLife. 2014;3.  https://doi.org/10.7554/eLife.02851  PMID: 24972829 
  16. Messina JP, Brady OJ, Pigott DM, Brownstein JS, Hoen AG, Hay SI. A global compendium of human dengue virus occurrence. Sci Data. 2014;1:140004.  https://doi.org/10.1038/sdata.2014.4  PMID: 25977762 
  17. Kraemer MU, Sinka ME, Duda KA, Mylne AQ, Shearer FM, Barker CM, et al. The global distribution of the arbovirus vectors Aedes aegypti and Ae. albopictus. eLife. 2015;4:e08347.  https://doi.org/10.7554/eLife.08347  PMID: 26126267 
  18. Gérardin P, Guernier V, Perrau J, Fianu A, Le Roux K, Grivard P, et al. Estimating Chikungunya prevalence in La Réunion Island outbreak by serosurveys: two methods for two critical times of the epidemic. BMC Infect Dis. 2008;8(1):99.  https://doi.org/10.1186/1471-2334-8-99  PMID: 18662384 
  19. Nitatpattana N, Kanjanopas K, Yoksan S, Satimai W, Vongba N, Langdatsuwan S, et al. Long-term persistence of Chikungunya virus neutralizing antibodies in human populations of North Eastern Thailand. Virol J. 2014;11(1):183.  https://doi.org/10.1186/1743-422X-11-183  PMID: 25330992 
  20. Phillips SJ, Dudík M, Elith J, Graham CH, Lehmann A, Leathwick J, et al. Sample selection bias and presence-only distribution models: implications for background and pseudo-absence data. Ecol Appl. 2009;19(1):181-97.  https://doi.org/10.1890/07-2153.1  PMID: 19323182 
  21. Kraemer MU, Sinka ME, Duda KA, Mylne A, Shearer FM, Brady OJ, et al. The global compendium of Aedes aegypti and Ae. albopictus occurrence. Sci Data. 2015;2:150035.  https://doi.org/10.1038/sdata.2015.35  PMID: 26175912 
  22. Brady OJ, Golding N, Pigott DM, Kraemer MU, Messina JP, Reiner RC Jr, et al. Global temperature constraints on Aedes aegypti and Ae. albopictus persistence and competence for dengue virus transmission. Parasit Vectors. 2014;7(1):338.  https://doi.org/10.1186/1756-3305-7-338  PMID: 25052008 
  23. Weiss DJ, Atkinson PM, Bhatt S, Mappin B, Hay SI, Gething PW. An effective approach for gap-filling continental scale remotely sensed time-series. ISPRS J Photogramm Remote Sens. 2014;98:106-18.  https://doi.org/10.1016/j.isprsjprs.2014.10.001  PMID: 25642100 
  24. Luz C, Tai MHH, Santos AH, Silva HHG. Impact of moisture on survival of Aedes aegypti eggs and ovicidal activity of Metarhizium anisopliae under laboratory conditions. Mem Inst Oswaldo Cruz. 2008;103(2):214-5.  https://doi.org/10.1590/S0074-02762008000200016  PMID: 18425277 
  25. Estallo EL, Lamfri MA, Scavuzzo CM, Almeida FF, Introini MV, Zaidenberg M, et al. Models for predicting Aedes aegypti larval indices based on satellite images and climatic variables. J Am Mosq Control Assoc. 2008;24(3):368-76.  https://doi.org/10.2987/5705.1  PMID: 18939688 
  26. Balk DL, Deichmann U, Yetman G, Pozzi F, Hay SI, Nelson A. Determining global population distribution: methods, applications and data. Adv Parasitol. 2006;62:119-56.  https://doi.org/10.1016/S0065-308X(05)62004-0  PMID: 16647969 
  27. Uchida H, Nelson A. Agglomeration index: Towards a New Measure of Urban Concentration. Background paper for the World Bank's World Development Report. Washington D.C.: World Bank; 2009.
  28. Demanou M, Antonio-Nkondjio C, Ngapana E, Rousset D, Paupy C, Manuguerra J-C, et al. Chikungunya outbreak in a rural area of Western Cameroon in 2006: A retrospective serological and entomological survey. BMC Res Notes. 2010;3(1):128.  https://doi.org/10.1186/1756-0500-3-128  PMID: 20444282 
  29. Peyrefitte CN, Bessaud M, Pastorino BAM, Gravier P, Plumet S, Merle OL, et al. Circulation of Chikungunya virus in Gabon, 2006-2007. J Med Virol. 2008;80(3):430-3.  https://doi.org/10.1002/jmv.21090  PMID: 18205212 
  30. Sudeep AB, Parashar D. Chikungunya: an overview. J Biosci. 2008;33(4):443-9.  https://doi.org/10.1007/s12038-008-0063-2  PMID: 19208970 
  31. Schuffenecker I, Iteman I, Michault A, Murri S, Frangeul L, Vaney M-C, et al. Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak. PLoS Med. 2006;3(7):e263.  https://doi.org/10.1371/journal.pmed.0030263  PMID: 16700631 
  32. Fischer D, Thomas SM, Suk JE, Sudre B, Hess A, Tjaden NB, et al. Climate change effects on Chikungunya transmission in Europe: geospatial analysis of vector’s climatic suitability and virus’ temperature requirements. Int J Health Geogr. 2013;12(1):51.  https://doi.org/10.1186/1476-072X-12-51  PMID: 24219507 
  33. Leparc-Goffart I, Nougairede A, Cassadou S, Prat C, de Lamballerie X. Chikungunya in the Americas. Lancet. 2014;383(9916):514.  https://doi.org/10.1016/S0140-6736(14)60185-9  PMID: 24506907 
  34. Van Bortel W, Dorleans F, Rosine J, Blateau A, Rousset D, Matheus S, et al. Chikungunya outbreak in the Caribbean region, December 2013 to March 2014, and the significance for Europe. Euro Surveill. 2014;19(13):20759.  https://doi.org/10.2807/1560-7917.ES2014.19.13.20759  PMID: 24721539 
  35. Pulmanausahakul R, Roytrakul S, Auewarakul P, Smith DR. Chikungunya in Southeast Asia: understanding the emergence and finding solutions. Int J Infect Dis. 2011;15(10):e671-6.  https://doi.org/10.1016/j.ijid.2011.06.002  PMID: 21775183 
  36. Lanciotti RS, Valadere AM, .Transcontinental movement of Asian genotype chikungunya virus. Emerg Infect Dis. 2014;20(8):1400-2.  https://doi.org/10.3201/eid2008.140268  PMID: 25076384 
  37. Azami NAM, Salleh SA, Shah SA, Neoh HM, Othman Z, Zakaria SZS, et al. Emergence of chikungunya seropositivity in healthy Malaysian adults residing in outbreak-free locations: chikungunya seroprevalence results from the Malaysian Cohort. BMC Infect Dis. 2013;13(1):67.  https://doi.org/10.1186/1471-2334-13-67  PMID: 23379541 
  38. Pulmanausahakul R, Roytrakul S, Auewarakul P, Smith DR. Chikungunya in Southeast Asia: understanding the emergence and finding solutions. Int J Infect Dis. 2011;15(10):e671-6.  https://doi.org/10.1016/j.ijid.2011.06.002  PMID: 21775183 
  39. Wu D, Wu J, Zhang Q, Zhong H, Ke C, Deng X, et al. Chikungunya outbreak in Guangdong Province, China, 2010. Emerg Infect Dis. 2012;18(3):493-5.  https://doi.org/10.3201/eid1803.110034  PMID: 22377135 
  40. Pun SB, Bastola A, Shah R. First report of Chikungunya virus infection in Nepal. J Infect Dev Ctries. 2014;8(6):790-2.  https://doi.org/10.3855/jidc.3701  PMID: 24916880 
  41. Wang J, Zhang H, Sun X, Fu S, Wang H, Feng Y, et al. Distribution of mosquitoes and mosquito-borne arboviruses in Yunnan Province near the China-Myanmar-Laos border. Am J Trop Med Hyg. 2011;84(5):738-46.  https://doi.org/10.4269/ajtmh.2011.10-0294  PMID: 21540383 
  42. Wu J-Y, Lun Z-R, James AA, Chen X-G. Dengue Fever in mainland China. Am J Trop Med Hyg. 2010;83(3):664-71.  https://doi.org/10.4269/ajtmh.2010.09-0755  PMID: 20810836 
  43. Nunes MRT, Faria NR, de Vasconcelos JM, Golding N, Kraemer MU, de Oliveira LF, et al. Emergence and potential for spread of Chikungunya virus in Brazil. BMC Med. 2015;13(102):102.  https://doi.org/10.1186/s12916-015-0348-x  PMID: 25976325 
  44. Jaenisch T, Junghanss T, Wills B, Brady OJ, Eckerle I, Farlow A, et al. Dengue in Africa Study Group. Dengue expansion in Africa-not recognized or not happening? Emerg Infect Dis. 2014;20(10):e140487.  https://doi.org/10.3201/eid2010.140487  PMID: 25271370 
  45. Ledermann JP, Guillaumot L, Yug L, Saweyog SC, Tided M, Machieng P, et al. Aedes hensilli as a potential vector of Chikungunya and Zika viruses. PLoS Negl Trop Dis. 2014;8(10):e3188.  https://doi.org/10.1371/journal.pntd.0003188  PMID: 25299181 
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