1887
Rapid communication Open Access
Like 0

Abstract

We describe the dynamics of Zika virus (ZIKV) infection in a man in his early 40s who developed fever and rash after returning from Haiti to Italy, in January 2016. Follow-up laboratory testing demonstrated detectable ZIKV RNA in plasma up to day 9 after symptom onset and in urine and saliva up to days 15 and 47, respectively. Notably, persistent shedding of ZIKV RNA was demonstrated in semen, still detectable at 181 days after onset.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2016.21.32.30316
2016-08-11
2017-10-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.32.30316
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/21/32/eurosurv-21-30316-1.html?itemId=/content/10.2807/1560-7917.ES.2016.21.32.30316&mimeType=html&fmt=ahah

References

  1. Barzon L, Pacenti M, Berto A, Sinigaglia A, Franchin E, Lavezzo E, et al. Isolation of infectious Zika virus from saliva and prolonged viral RNA shedding in a traveller returning from the Dominican Republic to Italy, January 2016. Euro Surveil. 2016;21(10):pii:30159.
  2. Scaramozzino N, Crance JM, Jouan A, DeBriel DA, Stoll F, Garin D. Comparison of flavivirus universal primer pairs and development of a rapid, highly sensitive heminested reverse transcription-PCR assay for detection of flaviviruses targeted to a conserved region of the NS5 gene sequences. J Clin Microbiol. 2001;39(5):1922-7.  https://doi.org/10.1128/JCM.39.5.1922-1927.2001  PMID: 11326014 
  3. Zika virus infection: global update on epidemiology and potentially associated clinical manifestations. Wkly Epidemiol Rec. 2016;91(7):73-81. PMID: 26897760 
  4. World Health Organization (WHO). WHO Director-General summarizes the outcome of the Emergency Committee regarding clusters of microcephaly and Guillain-Barré syndrome. 1 Feb 2016. Geneva: WHO; 2016. Available from: http://www.who.int/mediacentre/news/statements/2016/emergency-committee-zika-microcephaly/en/
  5. D’Ortenzio E, Matheron S, Yazdanpanah Y, de Lamballerie X, Hubert B, Piorkowski G, et al. Evidence of sexual transmission of Zika virus. N Engl J Med. 2016;374(22):2195-8.  https://doi.org/10.1056/NEJMc1604449  PMID: 27074370 
  6. Frank C, Cadar D, Schlaphof A, Neddersen N, Günther S, Schmidt-Chanasit J, et al. Sexual transmission of Zika virus in Germany, April 2016. Euro Surveill. 2016;21(23):30252.  https://doi.org/10.2807/1560-7917.ES.2016.21.23.30252  PMID: 27311329 
  7. Harrower J, Kiedrzynski T, Baker S, Upton A, Rahnama F, Sherwood J, et al. Sexual transmission of Zika virus and persistence in semen, New Zealand, 2016. Emerg Infect Dis. 2016;22(10).  https://doi.org/10.3201/eid2210.160951  PMID: 27454745 
  8. Atkinson B, Hearn P, Afrough B, Lumley S, Carter D, Aarons EJ, et al. Detection of Zika virus in semen. Emerg Infect Dis. 2016;22(5):940.  https://doi.org/10.3201/eid2205.160107  PMID: 27088817 
  9. Mansuy JM, Pasquier C, Daudin M, Chapuy-Regaud S, Moinard N, Chevreau C, et al. Zika virus in semen of a patient returning from a non-epidemic area. Lancet Infect Dis. 2016;16(8):894-5.  https://doi.org/10.1016/S1473-3099(16)30153-0  PMID: 27477981 
  10. Turmel JM, Abgueguen P, Hubert B, Vandamme YM, Maquart M, Le Guillou-Guillemette H, et al. Late sexual transmission of Zika virus related to persistence in the semen. Lancet. 2016;387(10037):2501.  https://doi.org/10.1016/S0140-6736(16)30775-9  PMID: 27287833 
  11. Prisant N, Bujan L, Benichou H, Hayot PH, Pavili L, Lurel S, et al. Zika virus in the female genital tract. Lancet Infect Dis. 2016; pii: S1473-3099(16)30193-1. doi:  https://doi.org/10.1016/S1473-3099(16)30193-1 .
  12. Petersen EE, Polen KN, Meaney-Delman D, Ellington SR, Oduyebo T, Cohn A, et al. Update: Interim Guidance for Health Care Providers Caring for Women of Reproductive Age with Possible Zika Virus Exposure--United States, 2016. MMWR Morb Mortal Wkly Rep. 2016;65(12):315-22.  https://doi.org/10.15585/mmwr.mm6512e2  PMID: 27031943 
  13. World Health Organization (WHO). Prevention of sexual transmission of Zika virus. Interim guidance. 7 June 2016. WHO/ZIKV/MOC/16.1Rev.2. Geneva: WHO. Available from: http://www.who.int/csr/resources/publications/zika/sexual-transmission-prevention/en/
  14. Reusken C, Pas S, GeurtsvanKessel C, Mögling R, van Kampen J, Langerak T, et al. Longitudinal follow-up of Zika virus RNA in semen of a traveller returning from Barbados to the Netherlands with Zika virus disease, March 2016. Euro Surveill. 2016;21(23):30251.  https://doi.org/10.2807/1560-7917.ES.2016.21.23.30251  PMID: 27313200 
  15. Musso D, Roche C, Robin E, Nhan T, Teissier A, Cao-Lormeau VM. Potential sexual transmission of Zika virus. Emerg Infect Dis. 2015;21(2):359-61.  https://doi.org/10.3201/eid2102.141363  PMID: 25625872 
  16. Mansuy JM, Dutertre M, Mengelle C, Fourcade C, Marchou B, Delobel P, et al. Zika virus: high infectious viral load in semen, a new sexually transmitted pathogen? Lancet Infect Dis. 2016;16(4):405.  https://doi.org/10.1016/S1473-3099(16)00138-9  PMID: 26949027 
  17. Freour T, Mirallié S, Hubert B, Splingart C, Barrière P, Maquart M, et al. Sexual transmission of Zika virus in an entirely asymptomatic couple returning from a Zika epidemic area, France, April 2016. Euro Surveill. 2016;21(23): pi=30254.
/content/10.2807/1560-7917.ES.2016.21.32.30316
Loading

Data & Media loading...

Comment has been disabled for this content
Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error