1887
Research article Open Access
Like 0

Abstract

Mumps outbreaks in highly vaccinated populations continue to be reported globally. Therefore, quantifying the burden of mumps morbidity accurately will be necessary to better assess the impact of mumps vaccination programmes. We aim to estimate the true morbidity resulting from mumps complications in terms of hospitalised orchitis, meningitis, oophoritis and pancreatitis in England during the outbreak in 2004/05. This outbreak in England led to a clear increase in hospitalisations coded to mumps for complications of orchitis in those born in the 1970s and 1980s and possibly for meningitis in those born in the 1980s. A simple statistical model, based on analysing time trends for diagnosed complications in hospital databases with routine laboratory surveillance data, found that the actual morbidity was much higher. There were 2.5 times (166 cases) more mumps orchitis cases in the 1970s cohort and 2.0 times (708 cases) more mumps orchitis cases in the 1980s cohort than complications coded to mumps in hospital databases. Our study demonstrated that the mumps outbreak in England 2004/05 resulted in a substantial increase in hospitalised mumps complications, and the model we used can improve the ascertainment of morbidity from a mumps outbreak.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2016.21.33.30320
2016-08-18
2017-10-20
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.33.30320
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/21/33/eurosurv-21-30320-4.html?itemId=/content/10.2807/1560-7917.ES.2016.21.33.30320&mimeType=html&fmt=ahah

References

  1. Hviid A, Rubin S, Mühlemann K. Mumps. Lancet. 2008;371(9616):932-44.  https://doi.org/10.1016/S0140-6736(08)60419-5  PMID: 18342688 
  2. Gupta RK, Best J, MacMahon E. Mumps and the UK epidemic 2005. BMJ. 2005;330(7500):1132-5.  https://doi.org/10.1136/bmj.330.7500.1132  PMID: 15891229 
  3. Plotkin S. Mumps vaccine. In: Plotkin SA, Orenstein WA, editors. Vaccines. 4th ed. Philadelphia: Elselvier; 2004. p 441-69.
  4. Savage E, Ramsay M, White J, Beard S, Lawson H, Hunjan R, et al. Mumps outbreaks across England and Wales in 2004: observational study. BMJ. 2005;330(7500):1119-20.  https://doi.org/10.1136/bmj.330.7500.1119  PMID: 15891227 
  5. Health Protection Agency (HPA). Confirmed cases of mumps by age and region: 1996-2013. London: HPA; [Accessed: 29 Feb 2016]. Available from: http://webarchive.nationalarchives.gov.uk/20140505192926/http://www.hpa.org.uk/web/HPAweb&HPAwebStandard/HPAweb_C/1195733841496#2002
  6. Anderson RMMR, May RM. Vaccination and herd immunity to infectious diseases. Nature. 1985;318(6044):323-9.  https://doi.org/10.1038/318323a0  PMID: 3906406 
  7. Sane J, Gouma S, Koopmans M, de Melker H, Swaan C, van Binnendijk R, et al. Epidemic of mumps among vaccinated persons, The Netherlands, 2009-2012. Emerg Infect Dis. 2014;20(4):643-8.  https://doi.org/10.3201/eid2004.131681  PMID: 24655811 
  8. Cortese MM, Jordan HT, Curns AT, Quinlan PA, Ens KA, Denning PM, et al. Mumps vaccine performance among university students during a mumps outbreak. Clin Infect Dis. 2008;46(8):1172-80.  https://doi.org/10.1086/529141  PMID: 18444852 
  9. Deeks SL, Lim GH, Simpson MA, Gagné L, Gubbay J, Kristjanson E, et al. An assessment of mumps vaccine effectiveness by dose during an outbreak in Canada. CMAJ. 2011;183(9):1014-20.  https://doi.org/10.1503/cmaj.101371  PMID: 21576295 
  10. Calvert N, Ashton JR, Garnett E. Mumps outbreak in private schools: public health lessons for the post-Wakefield era. Lancet. 2013;381(9878):1625-6.  https://doi.org/10.1016/S0140-6736(13)60953-8  PMID: 23628443 
  11. Cordeiro E, Ferreira M, Rodrigues F, Palminha P, Vinagre E, Pimentel JP. Mumps Outbreak among Highly Vaccinated Teenagers and Children in the Central Region of Portugal, 2012-2013. Acta Med Port. 2015;28(4):435-41.  https://doi.org/10.20344/amp.5756  PMID: 26574977 
  12. Dayan GH, Quinlisk MP, Parker AA, Barskey AE, Harris ML, Schwartz JM, et al. Recent resurgence of mumps in the United States. N Engl J Med. 2008;358(15):1580-9.  https://doi.org/10.1056/NEJMoa0706589  PMID: 18403766 
  13. Hukic M, Hajdarpasic A, Ravlija J, Ler Z, Baljic R, Dedeic Ljubovic A, et al. Mumps outbreak in the Federation of Bosnia and Herzegovina with large cohorts of susceptibles and genetically diverse strains of genotype G, Bosnia and Herzegovina, December 2010 to September 2012. Euro Surveill. 2014;19(33):20879.  https://doi.org/10.2807/1560-7917.ES2014.19.33.20879  PMID: 25166347 
  14. Braeye T, Linina I, De Roy R, Hutse V, Wauters M, Cox P, et al. Mumps increase in Flanders, Belgium, 2012-2013: results from temporary mandatory notification and a cohort study among university students. Vaccine. 2014;32(35):4393-8.  https://doi.org/10.1016/j.vaccine.2014.06.069  PMID: 24973734 
  15. Barskey AESC, Schulte C, Rosen JB, Handschur EF, Rausch-Phung E, Doll MK, et al. Mumps outbreak in Orthodox Jewish communities in the United States. N Engl J Med. 2012;367(18):1704-13.  https://doi.org/10.1056/NEJMoa1202865  PMID: 23113481 
  16. Park SH. Resurgence of mumps in Korea. Infect Chemother. 2015;47(1):1-11.  https://doi.org/10.3947/ic.2015.47.1.1  PMID: 25844258 
  17. Warrener L, Samuel D. Evaluation of a commercial assay for the detection of mumps specific IgM antibodies in oral fluid and serum specimens. J Clin Virol. 2006;35(2):130-4.  https://doi.org/10.1016/j.jcv.2005.10.008  PMID: 16318926 
  18. Public Health England (PHE). Laboratory confirmed cases of measles, mumps and rubella, England: April to June 2015. Health Protection Report. 2015;9(30). Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/457407/hpr3015_mmr.pdf
  19. World Health Organization (WHO). International statistical classification of diseases and related health problems. 10th Revision. Volume 2. Instruction manual. 2010 ed. Geneva: WHO; 2011. Available from: http://www.who.int/classifications/icd/ICD10Volume2_en_2010.pdf
  20. Health, Social Care Information Centre (HSIC). Hospital episode statistics. 2012 Leeds: HSIC. [Accessed: 29 Feb 2016]. Available from: http://www.hscic.gov.uk/hes
  21. Ryan MJRM, Ramsay M, Brown D, Gay NJ, Farrington CP, Wall PG. Hospital admissions attributable to rotavirus infection in England and Wales. J Infect Dis. 1996;174(Suppl 1):S12-8.  https://doi.org/10.1093/infdis/174.Supplement_1.S12  PMID: 8752285 
  22. Müller-Pebody B, Edmunds WJ, Zambon MC, Gay NJ, Crowcroft NS. Contribution of RSV to bronchiolitis and pneumonia-associated hospitalizations in English children, April 1995-March 1998. Epidemiol Infect. 2002;129(1):99-106.  https://doi.org/10.1017/S095026880200729X  PMID: 12211603 
  23. Granerod J, Davison KL, Ramsay ME, Crowcroft NS. Investigating the aetiology of and evaluating the impact of the Men C vaccination programme on probable meningococcal disease in England and Wales. Epidemiol Infect. 2006;134(5):1037-46.  https://doi.org/10.1017/S0950268806005991  PMID: 16492318 
  24. Zamir CS, Schroeder H, Shoob H, Abramson N, Zentner G. Characteristics of a large mumps outbreak: Clinical severity, complications and association with vaccination status of mumps outbreak cases. Hum Vaccin Immunother. 2015;Apr 15:0.
  25. Gazibera B, Gojak R, Drnda A, Osmic A, Mostarac N, Jusufi-Huric I, et al. Spermiogram part of population with the manifest orchitis during an ongoing epidemic of mumps. Med Arh. 2012;66(3) Suppl 1;27-9.  https://doi.org/10.5455/medarh.2012.66.s27-s29  PMID: 22937687 
  26. Dejucq N, Jégou B. Viruses in the mammalian male genital tract and their effects on the reproductive system. Microbiol Mol Biol Rev. 2001;65(2):208-31.  https://doi.org/10.1128/MMBR.65.2.208-231.2001  PMID: 11381100 
  27. Lane TMHJ, Hines J. The management of mumps orchitis. BJU Int. 2006;97(1):1-2.  https://doi.org/10.1111/j.1464-410X.2006.05869.x  PMID: 16336315 
  28. Philip J, Selvan D, Desmond AD. Mumps orchitis in the non-immune postpubertal male: a resurgent threat to male fertility? BJU Int. 2006;97(1):138-41.  https://doi.org/10.1111/j.1464-410X.2006.05902.x  PMID: 16336344 
  29. Masarani M, Wazait H, Dinneen M. Mumps orchitis. Journal of the Royal Society of Medicine. 2006 2006/11//;99(11):573-5.
  30. Yung CF, Andrews N, Bukasa A, Brown KE, Ramsay M. Mumps complications and effects of mumps vaccination, England and Wales, 2002-2006. Emerg Infect Dis. 2011;17(4):661-7, quiz 766.  https://doi.org/10.3201/eid1704.101461  PMID: 21470456 
  31. Hahné S, Whelan J, van Binnendijk R, Swaan C, Fanoy E, Boot H, et al. Mumps vaccine effectiveness against orchitis. Emerg Infect Dis. 2012;18(1):191-3.  https://doi.org/10.3201/eid1801.111178  PMID: 22260843 
/content/10.2807/1560-7917.ES.2016.21.33.30320
Loading

Data & Media loading...

Comment has been disabled for this content
Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error