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Surveillance and outbreak report Open Access
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Abstract

From January 2014 to December 2014, 972 consecutive non-replicate carbapenemase-producing isolates from colonised or infected patients were collected at the Associated French National Reference Centre as part of the French national survey on antimicrobial resistance. It included 577 spp. (59%), 236 (24%), 108 spp. (11%), 50 spp. (5%), and a single spp. isolate (0.1%). Of 561 isolates, 35 were found to be resistant to colistin (6.2%). PFGE analysis revealed a clonal outbreak involving 15 isolates belonging to sequence type ST11, recovered in a single hospital in the Picardie region in northern France. Those clonally related isolates showed variable levels of resistance to colistin, ranging from 4 to 64 mg/L. They harboured the carbapenemase gene and the extended-spectrum beta-lactamase gene. Among the 91 isolates, seven were resistant to colistin and produced different types of carbapenemases. Surprisingly, none of the and spp. isolates showed resistance to colistin. This national survey including carbapenemase-producing isolates recovered in 2014 reported a high rate of colistin resistance in and (6.2% and 7.7%, respectively) in France.

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/content/10.2807/1560-7917.ES.2016.21.37.30339
2016-09-15
2017-10-23
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.37.30339
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