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Abstract

The increase in whooping cough (pertussis) incidence in many countries with high routine vaccination coverage is alarming, with incidence in the US reaching almost 50,000 reported cases per year, reflecting incidence levels not seen since the 1950s. While the potential explanations for this resurgence remain debated, we face an urgent need to protect newborns, especially during the time window between birth and the first routine vaccination dose. Maternal immunisation has been proposed as an effective strategy for protecting neonates, who are at higher risk of severe pertussis disease and mortality. However, if maternally derived antibodies adversely affect the immunogenicity of the routine schedule, through blunting effects, we may observe a gradual degradation of herd immunity. ‘Wasted’ vaccines would result in an accumulation of susceptible children in the population, specifically leading to an overall increase in incidence in older age groups. In this Perspective, we discuss potential long-term epidemiological effects of maternal immunisation, as determined by possible immune interference outcomes.

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/content/10.2807/1560-7917.ES.2017.22.15.30510
2017-04-13
2017-10-20
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.15.30510
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References

  1. Anderson R, May R. Infectious diseases of humans. Dynamics and control. Oxford Science Publications; 1991.
  2. World Health Organization (WHO) Study on global Ageing and adult health (SAGE) pertussis working group. Background paper. Geneva: WHO; 2014. Available from: http://www.who.int/immunization/sage/meetings/2014/april/1_Pertussis_background_FINAL4_web.pdf
  3. Domenech de Celles M, Magpantay FMG, King AA, Rohani P. The pertussis enigma: reconciling epidemiology, immunology and evolution. Proc Biol Sci. 2016;283(1822):20152309.
  4. Skoff TH, Kenyon C, Cocoros N, Liko J, Miller L, Kudish K, et al. Sources of infant pertussis infection in the United States. Pediatrics. 2015;136(4):635-41.  https://doi.org/10.1542/peds.2015-1120  PMID: 26347437 
  5. Bart MJ, Harris SR, Advani A, Arakawa Y, Bottero D, Bouchez V, et al. Global population structure and evolution of Bordetella pertussis and their relationship with vaccination. MBio. 2014;5(2):e01074.  https://doi.org/10.1128/mBio.01074-14  PMID: 24757216 
  6. Kretzschmar M, Teunis PFM, Pebody RG. Incidence and reproduction numbers of pertussis: estimates from serological and social contact data in five European countries. PLoS Med. 2010;7(6):e1000291.  https://doi.org/10.1371/journal.pmed.1000291  PMID: 20585374 
  7. Warfel JM, Zimmerman LI, Merkel TJ. Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model. Proc Natl Acad Sci USA. 2014;111(2):787-92.  https://doi.org/10.1073/pnas.1314688110  PMID: 24277828 
  8. Wood N, McIntyre P. Pertussis: review of epidemiology, diagnosis, management and prevention. Paediatr Respir Rev. 2008;9(3):201-11, quiz 211-2.  https://doi.org/10.1016/j.prrv.2008.05.010  PMID: 18694712 
  9. Magpantay FM, Riolo MA, DE Cellès MD, King AA, Rohani P, De Cellès MD, et al. . Epidemiological consequences of imperfect vaccines for immunizing infections. SIAM J Appl Math. 2014;74(6):1810-30.  https://doi.org/10.1137/140956695  PMID: 25878365 
  10. Riolo MA, King AA, Rohani P. Can vaccine legacy explain the British pertussis resurgence? Vaccine. 2013;31(49):5903-8.  https://doi.org/10.1016/j.vaccine.2013.09.020  PMID: 24139837 
  11. Munoz FM, Bond NH, Maccato M, Pinell P, Hammill HA, Swamy GK, et al. Safety and immunogenicity of tetanus diphtheria and acellular pertussis (Tdap) immunization during pregnancy in mothers and infants: a randomized clinical trial. JAMA. 2014;311(17):1760-9.  https://doi.org/10.1001/jama.2014.3633  PMID: 24794369 
  12. Bento AI, Rohani P. Forecasting epidemiological consequences of maternal immunization. Clin Infect Dis. 2016;63(suppl 4):S205-12.  https://doi.org/10.1093/cid/ciw557  PMID: 27838674 
  13. Siegrist CA. Blame vaccine interference, not neonatal immunization, for suboptimal responses after neonatal diphtheria, tetanus, and acellular pertussis immunization. J Pediatr. 2008;153(3):305-7.  https://doi.org/10.1016/j.jpeds.2008.04.032  PMID: 18718256 
  14. Van Savage J, Decker MD, Edwards KM, Sell SH, Karzon DT. Natural history of pertussis antibody in the infant and effect on vaccine response. J Infect Dis. 1990;161(3):487-92.  https://doi.org/10.1093/infdis/161.3.487  PMID: 2313127 
  15. Siegrist CA. Mechanisms by which maternal antibodies influence infant vaccine responses: review of hypotheses and definition of main determinants. Vaccine. 2003;21(24):3406-12.  https://doi.org/10.1016/S0264-410X(03)00342-6  PMID: 12850349 
  16. Englund JA, Anderson EL, Reed GF, Decker MD, Edwards KM, Pichichero ME, et al. The effect of maternal antibody on the serologic response and the incidence of adverse reactions after primary immunization with acellular and whole-cell pertussis vaccines combined with diphtheria and tetanus toxoids. Pediatrics. 1995;96(3 Pt 2):580-4. PMID: 7659480 
  17. Kendrick P, Thompson M, Elderling G. Immunity response of mothers and babies to injections of pertussis during pregnancy. Am J Dis Child. 1945;70(1):25-8. Available from: https://doi.org/10.1001/archpedi.1945.02020190032005
  18. Initiative for Vaccine Research (IVR). Immunization, Vaccines and Biologicals (IVB), Family, Women's and Children's Health (FWC) Cluster. Maternal immunization research and implementation portfolio. Geneva: World Health Organization; 2015. Available from: http://www.who.int/immunization/research/development/Portfolio_maternal_immunization_activities.pdf?ua=1 Last accessed April 2017
  19. Eberhardt CS, Blanchard-Rohner G, Lemaître B, Boukrid M, Combescure C, Othenin-Girard V, et al. Maternal immunization earlier in pregnancy maximizes antibody transfer and expected infant seropositivity against pertussis. Clin Infect Dis. 2016;62(7):829-36.  https://doi.org/10.1093/cid/ciw027  PMID: 26797213 
  20. Hardy-Fairbanks AJ, Pan SJ, Decker MD, Johnson DR, Greenberg DP, Kirkland KB, et al. Immune responses in infants whose mothers received Tdap vaccine during pregnancy. Pediatr Infect Dis J. 2013;32(11):1257-60.  https://doi.org/10.1097/INF.0b013e3182a09b6a  PMID: 23799518 
  21. Ladhani SN, Andrews NJ, Southern J, Jones CE, Amirthalingam G, Waight PA, et al. Antibody responses after primary immunization in infants born to women receiving a pertussis-containing vaccine during pregnancy: single arm observational study with a historical comparator. Clin Infect Dis. 2015;61(11):1637-44.  https://doi.org/10.1093/cid/civ695  PMID: 26374816 
  22. Hoang HTT, Leuridan E, Maertens K, Nguyen TD, Hens N, Vu NH, et al. Pertussis vaccination during pregnancy in Vietnam: Results of a randomized controlled trial Pertussis vaccination during pregnancy. Vaccine. 2016;34(1):151-9.  https://doi.org/10.1016/j.vaccine.2015.10.098  PMID: 26529073 
  23. Maertens K, Caboré RN, Huygen K, Hens N, Van Damme P, Leuridan E. Pertussis vaccination during pregnancy in Belgium: Results of a prospective controlled cohort study. Vaccine. 2016;34(1):142-50.  https://doi.org/10.1016/j.vaccine.2015.10.100  PMID: 26592142 
  24. Maertens K, Hoang TT, Nguyen TD, Caboré RN, Duong TH, Huygen K, et al. The Effect of Maternal Pertussis Immunization on Infant Vaccine Responses to a Booster Pertussis-Containing Vaccine in Vietnam. Clin Infect Dis. 2016;63(suppl 4):S197-204.  https://doi.org/10.1093/cid/ciw551  PMID: 27838673 
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