1887
Rapid communication Open Access
Like 0

Abstract

We describe three cases of bloodstream infection caused by colistin-resistant in patients in a tertiary hospital in Italy, between August 2016 and January 2017. Whole genome sequencing detected the gene in three isolated strains belonging to different sequence types (STs). This occurrence of three cases with -positive belonging to different STs in six months suggests a widespread problem in settings where high multidrug resistance is endemic such as in Italy.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2017.22.16.30517
2017-04-20
2017-12-18
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.16.30517
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/22/16/eurosurv-22-30517-1.html?itemId=/content/10.2807/1560-7917.ES.2017.22.16.30517&mimeType=html&fmt=ahah

References

  1. Liu YY, Wang Y, Walsh TR, Yi LX, Zhang R, Spencer J, et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis. 2016;16(2):161-8.  https://doi.org/10.1016/S1473-3099(15)00424-7  PMID: 26603172 
  2. Li J, Nation RL, Turnidge JD, Milne RW, Coulthard K, Rayner CR, et al. Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections. Lancet Infect Dis. 2006;6(9):589-601.  https://doi.org/10.1016/S1473-3099(06)70580-1  PMID: 16931410 
  3. European Centre for Disease Prevention and Control (ECDC). Plasmid-mediated colistin resistance in Enterobacteriaceae. Stockolm: ECDC; 2016. Available from: http://ecdc.europa.eu/en/publications/Publications/enterobacteriaceae-risk-assessment-diseases-caused-by-antimicrobial-resistant-microorganisms-europe-june-2016.pdf
  4. Walkty A, Karlowsky JA, Adam HJ, Lagacé-Wiens P, Baxter M, Mulvey MR, et al. Frequency of MCR-1-mediated colistin resistance among Escherichia coli clinical isolates obtained from patients in Canadian hospitals (CANWARD 2008-2015). CMAJ Open. 2016;4(4):E641-5.  https://doi.org/10.9778/cmajo.20160080  PMID: 28018876 
  5. Quan J, Li X, Chen Y, Jiang Y, Zhou Z, Zhang H, et al. Prevalence of mcr-1 in Escherichia coli and Klebsiella pneumoniae recovered from bloodstream infections in China: a multicentre longitudinal study. Lancet Infect Dis. 2017;17(4):400-10.  PMID: 28139430 
  6. Wang Y, Tian GB, Zhang R, Shen Y, Tyrrell JM, Huang X, et al. Prevalence, risk factors, outcomes, and molecular epidemiology of mcr-1-positive Enterobacteriaceae in patients and healthy adults from China: an epidemiological and clinical study. Lancet Infect Dis. 2017;17(4):390-9.  https://doi.org/10.1016/S1473-3099(16)30527-8  PMID: 28139431 
  7. Nordmann P, Lienhard R, Kieffer N, Clerc O, Poirel L. Plasmid-Mediated Colistin-Resistant Escherichia coli in Bacteremia in Switzerland. Clin Infect Dis. 2016;62(10):1322-3.  https://doi.org/10.1093/cid/ciw124  PMID: 26936673 
  8. Skov RL, Monnet DL. Plasmid-mediated colistin resistance (mcr-1 gene): three months later, the story unfolds. Euro Surveill. 2016;21(9):30155.  https://doi.org/10.2807/1560-7917.ES.2016.21.9.30155  PMID: 26967914 
  9. European Committee on Antimicrobial Susceptibility Testing (EUCAST). Breakpoint tables for interpretation of MICs and zone diameters. Version 6.0, valid from 2016-01-01. Available from: http://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Breakpoint_tables/v_6.0_Breakpoint_table.pdf
  10. European Committee on Antimicrobial Susceptibility Testing (EUCAST). Recommendations for MIC determination of colistin (polymyxin E). As recommended by the joint CLSI-EUCAST Polymyxin Breakpoints Working Group. Växjö: EUCAST; 22 Mar 2016. Available from: http://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/General_documents/Recommendations_for_MIC_determination_of_colistin_March_2016.pdf
  11. Wirth T, Falush D, Lan R, Colles F, Mensa P, Wieler LH, et al. Sex and virulence in Escherichia coli: an evolutionary perspective. Mol Microbiol. 2006;60(5):1136-51.  https://doi.org/10.1111/j.1365-2958.2006.05172.x  PMID: 16689791 
  12. Cannatelli A, Giani T, Antonelli A, Principe L, Luzzaro F, Rossolini GM. First Detection of the mcr-1 Colistin Resistance Gene in Escherichia coli in Italy. Antimicrob Agents Chemother. 2016;60(5):3257-8.  https://doi.org/10.1128/AAC.00246-16  PMID: 26976865 
  13. Giufrè M, Monaco M, Accogli M, Pantosti A, Cerquetti MPAMURSA Study Group. Emergence of the colistin resistance mcr-1 determinant in commensal Escherichia coli from residents of long-term-care facilities in Italy. J Antimicrob Chemother. 2016;71(8):2329-31.  https://doi.org/10.1093/jac/dkw195  PMID: 27261262 
  14. Overdevest I, Haverkate M, Veenemans J, Hendriks Y, Verhulst C, Mulders A, et al. Prolonged colonisation with Escherichia coli O25:ST131 versus other extended-spectrum beta-lactamase-producing E. coli in a long-term care facility with high endemic level of rectal colonisation, the Netherlands, 2013 to 2014. Euro Surveill. 2016;21(42):30376.  https://doi.org/10.2807/1560-7917.ES.2016.21.42.30376  PMID: 27784530 
  15. Poirel L, Jayol A, Nordmann P. Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes. Clin Microbiol Rev. 2017;30(2):557-96.  https://doi.org/10.1128/CMR.00064-16  PMID: 28275006 
  16. Bernasconi OJ, Kuenzli E, Pires J, Tinguely R, Carattoli A, Hatz C, et al. Travelers can import colistin resistant Enterobacteriaceae, including those possessing the plasmid-mediated mcr-1 gene. Antimicrob Agents Chemother. 2016;60(8):5080-4.  https://doi.org/10.1128/AAC.00731-16  PMID: 27297483 
  17. Prim N, Rivera A, Rodríguez-Navarro J, Español M, Turbau M, Coll P, et al. Detection of mcr-1 colistin resistance gene in polyclonal Escherichia coli isolates in Barcelona, Spain, 2012 to 2015. Euro Surveill. 2016;21(13):30183.  https://doi.org/10.2807/1560-7917.ES.2016.21.13.30183  PMID: 27055477 
  18. Di Pilato V, Arena F, Tascini C, Cannatelli A, Henrici De Angelis L, Fortunato S, et al. mcr-1.2, a New mcr Variant Carried on a Transferable Plasmid from a Colistin-Resistant KPC Carbapenemase-Producing Klebsiella pneumoniae Strain of Sequence Type 512. Antimicrob Agents Chemother. 2016;60(9):5612-5.  https://doi.org/10.1128/AAC.01075-16  PMID: 27401575 
/content/10.2807/1560-7917.ES.2017.22.16.30517
Loading

Data & Media loading...

Comment has been disabled for this content
Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error