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Immunisation Information Systems (IIS) are computerised confidential population based-systems containing individual-level information on vaccines received in a given area. They benefit individuals directly by ensuring vaccination according to the schedule and they provide information to vaccine providers and public health authorities responsible for the delivery and monitoring of an immunisation programme. In 2016, the European Centre for Disease Prevention and Control (ECDC) conducted a survey on the level of implementation and functionalities of IIS in 30 European Union/European Economic Area (EU/EEA) countries. It explored the governance and financial support for the systems, IIS software, system characteristics in terms of population, identification of immunisation recipients, vaccinations received, and integration with other health record systems, the use of the systems for surveillance and programme management as well as the challenges involved with implementation. The survey was answered by 27 of the 30 EU/EEA countries having either a system in production at national or subnational levels (n = 16), or being piloted (n = 5) or with plans for setting up a system in the future (n = 6). The results demonstrate the added-value of IIS in a number of areas of vaccination programme monitoring such as monitoring vaccine coverage at local geographical levels, linking individual immunisation history with health outcome data for safety investigations, monitoring vaccine effectiveness and failures and as an educational tool for both vaccine providers and vaccine recipients. IIS represent a significant way forward for life-long vaccination programme monitoring.


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  1. Centers for Disease Control Prevention (CDC). About Immunization Information Systems. Atlanta: CDC; 2012 May 15 [Accessed 18 Oct 2016]. Available from: http://www.cdc.gov/vaccines/programs/iis/about.html
  2. World Health Organisation (WHO). WHO/UNICEF Joint Reporting Process. Geneva: WHO; 2013 [Accessed 18 Oct 2016]. Available from: http://www.who.int/immunization/monitoring_surveillance/routine/reporting/reporting/en/
  3. European Medicines Agency (EMA). Post-authorisation safety studies (PASS) [internet]. London: EMA. [Accessed 18 Oct 2016]. Available from: http://www.ema.europa.eu/ema/index.jsp?curl=pages/regulation/document_listing/document_listing_000377.jsp&mid=WC0b01ac058066e979
  4. Guthmann JP, Fonteneau L, Bonmarin I, Lévy-Bruhl D. Influenza vaccination coverage one year after the A(H1N1) influenza pandemic, France, 2010-2011. Vaccine. 2012;30(6):995-7.  https://doi.org/10.1016/j.vaccine.2011.12.011  PMID: 22178520 
  5. Poggensee G, Reuss A, Reiter S, Siedler A. Überblick und Bewertung der verfügbaren Datenquellen zur Inzidenz impfpräventabler Krankheiten, zum Durchimpfungsgrad und zum Immunstatus in Deutschland. [Overview and assessment of available data sources to determine incidence of vaccine preventable diseases, vaccination coverage, and immune status in Germany]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2009;52(11):1019-28.  https://doi.org/10.1007/s00103-009-0952-z  PMID: 19823785 
  6. Fonteneau L, Urcun JM, Guthmann JP, Collet M, Neulat N, Bristol-Gauzy P, et al. Couverture vaccinale des enfants âgés de 6 ans, scolarisés en grande section de maternelle, France, 2005–2006. [Vaccination coverage in 6-year-old preschool children, France, 2005-2006]. Arch Pediatr. 2013;20(3):241-7.  https://doi.org/10.1016/j.arcped.2012.12.019  PMID: 23375080 
  7. Schuck-Paim C, Taylor R, Lindley D, Klugman KP, Simonsen L. Use of near-real-time medical claims data to generate timely vaccine coverage estimates in the US: the dynamics of PCV13 vaccine uptake. Vaccine. 2013;31(50):5983-8.  https://doi.org/10.1016/j.vaccine.2013.10.038  PMID: 24144470 
  8. Rieck T, Feig M, Eckmanns T, Benzler J, Siedler A, Wichmann O. Vaccination coverage among children in Germany estimated by analysis of health insurance claims data. Hum Vaccin Immunother. 2014;10(2):476-84.  https://doi.org/10.4161/hv.26986  PMID: 24192604 
  9. Bielicki JA, Achermann R, Berger C. Timing of measles immunization and effective population vaccine coverage. Pediatrics. 2012;130(3):e600-6.  https://doi.org/10.1542/peds.2012-0132  PMID: 22908102 
  10. Cutts FT, Claquin P, Danovaro-Holliday MC, Rhoda DA. Monitoring vaccination coverage: Defining the role of surveys. Vaccine. 2016;34(35):4103-9.  https://doi.org/10.1016/j.vaccine.2016.06.053  PMID: 27349841 
  11. Svanström H, Callréus T, Hviid A. Temporal data mining for adverse events following immunization in nationwide Danish healthcare databases. Drug Saf. 2010;33(11):1015-25.  https://doi.org/10.2165/11537630-000000000-00000  PMID: 20925439 
  12. Nohynek H, Baum U, Syrjänen R, Ikonen N, Sundman J, Jokinen J. Effectiveness of the live attenuated and the inactivated influenza vaccine in two-year-olds - a nationwide cohort study Finland, influenza season 2015/16. Euro Surveill. 2016;21(38):30346.  https://doi.org/10.2807/1560-7917.ES.2016.21.38.30346  PMID: 27684447 
  13. Amirthalingam G, Andrews N, Campbell H, Ribeiro S, Kara E, Donegan K, et al. Effectiveness of maternal pertussis vaccination in England: an observational study. Lancet. 2014;384(9953):1521-8.  https://doi.org/10.1016/S0140-6736(14)60686-3  PMID: 25037990 
  14. Community Preventive Services Task Force. Recommendation for use of immunization information systems to increase vaccination rates. J Public Health Manag Pract. 2015;21(3):249-52. PMID: 24912083 
  15. World Health Organisation (WHO). European Vaccine Action Plan 2015 - 2020.Geneva:WHO; 2014. [Accessed 10 May 2016]. Available from: http://www.euro.who.int/__data/assets/pdf_file/0007/255679/WHO_EVAP_UK_v30_WEBx.pdf?ua=1
  16. Council of the European Union. Council conclusions on Childhood immunisation: successes and challenges of European childhood immunisation and the way forward. Brussels: Council of the European Union; 2011 June 6 [Accessed 18 Oct 2016]. Available from: http://www.consilium.europa.eu/uedocs/cms_Data/docs/pressdata/en/lsa/122391.pdf
  17. Council of the European Union. Council conclusions on vaccinations as an effective tool in public health. Brussels: Council of the European Union; 2014 Dec 1 [Accessed 18 Oct 2016]. Available from: http://www.consilium.europa.eu/uedocs/cms_data/docs/pressdata/en/lsa/145973.pdf
  18. Pebody R. Vaccine registers--experiences from Europe and elsewhere. Euro Surveill. 2012;17(17):1. PMID: 22551493 
  19. Vaccine European New Integrated Collaboration Effort. Survey on Functional Standards for Computerised Immunisation Registries in Europe 2008. 2008. [Accessed 18 Oct 2016]. Available from: http://venice.cineca.org/Final_Report_Functional_Standards_v1.0_.pdf
  20. European Centre for Disease Prevention and Control (ECDC). Immunisation information systems in the EU and EEA - Results of a survey on implementation and system characteristics. Stockholm: ECDC; 2017. Available from: http://ecdc.europa.eu/en/publications/Publications/immunisation-systems.pdf
  21. European Commission. EU Survey [internet]. 2016. [Accessed 19 Oct 2016]. Available from: https://ec.europa.eu/eusurvey/home/welcome
  22. European Commission. eurostat - Your key to European statistics. 2016. [Accessed 20 Oct 2016]. Available from: http://ec.europa.eu/eurostat/web/nuts/overview
  23. Nacionalni inštitut za javno zdravje [National Institute for Public Health]. Elektronski register cepljenih oseb in neželenih učinkov po cepljenju – eRCO. [The electronic register of persons who are vaccinated and adverse events following vaccination], [internet]. 2017 Jan 21 [Accessed 29 Mar 2017]. Available from: http://www.nijz.si/sl/elektronski-register-cepljenih-oseb-in-nezelenih-ucinkov-po-cepljenju-erco
  24. van Lier EAOP, Giesbers H, van Vliet JA, Drijfhout IH, Zonnenberg-Hoff IF, de Melker HE. Immunisation coverage National Immunisation Programme (NIP) in the Netherlands: Year of report 2016. 2016 [Accessed 19 Oct 2016]. Available from: http://www.rivm.nl/en/Documents_and_publications/Scientific/Reports/2016/juni/Immunisation_coverage_National_Immunisation_Programme_NIP_in_the_Netherlands_Year_of_report_2016
  25. Urquhart GA, Williams W, Tobias J, Welch FJ. Immunization information systems use during a public health emergency in the United States. J Public Health Manag Pract. 2007;13(5):481-5.  https://doi.org/10.1097/01.PHH.0000285201.54426.0c  PMID: 17762693 
  26. Gahr P, DeVries AS, Wallace G, Miller C, Kenyon C, Sweet K, et al. An outbreak of measles in an undervaccinated community. Pediatrics. 2014;134(1):e220-8.  https://doi.org/10.1542/peds.2013-4260  PMID: 24913790 
  27. Nohynek H, Jokinen J, Partinen M, Vaarala O, Kirjavainen T, Sundman J, et al. AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland. PLoS One. 2012;7(3):e33536.  https://doi.org/10.1371/journal.pone.0033536  PMID: 22470453 
  28. Arnheim-Dahlström L, Pasternak B, Svanström H, Sparén P, Hviid A. Autoimmune, neurological, and venous thromboembolic adverse events after immunisation of adolescent girls with quadrivalent human papillomavirus vaccine in Denmark and Sweden: cohort study. BMJ. 2013;347(oct09 4):f5906.  https://doi.org/10.1136/bmj.f5906  PMID: 24108159 
  29. Hviid A, Stellfeld M, Wohlfahrt J, Melbye M. Association between thimerosal-containing vaccine and autism. JAMA. 2003;290(13):1763-6.  https://doi.org/10.1001/jama.290.13.1763  PMID: 14519711 
  30. American Immunization Registry Association. About AIRA. 2016 [Accessed 19 Oct 2016]. Available from: http://www.immregistries.org/about-aira
  31. Australian Government Department of Health. Australian Immunisation Registers. 2016 Dec. 19 [Accessed 30 Mar 2017]. Available from: http://immunise.health.gov.au/internet/immunise/publishing.nsf/Content/about-immunisation-registers

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