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Abstract

Introduction

Hand, foot and mouth disease (HFMD) is usually caused by several serotypes from human enterovirus A species, including enterovirus 71 (EV-A71) and coxsackievirus A16 (CV-A16). Two inactivated monovalent EV-A71 vaccines have been recently licensed in China and monovalent CV-A16 vaccine and bivalent EV-A71 and CV-A16 vaccine are under development. : Using notifications from the national surveillance system, we describe the epidemiology and dynamics of HFMD in the country, before the introduction of EV-A71 vaccination, from 2008 through 2015. Laboratory-identified serotype categories, i.e. CV-A16, EV-A71 and other enteroviruses, circulated annually. EV-A71 remained the most virulent serotype and was the major serotype for fatal cases (range: 88.5–95.4%) and severe cases (range: 50.7–82.3%) across years. Except for 2013 and 2015, when other enteroviruses were more frequently found in mild HFMD (48.8% and 52.5%), EV-A71 was more frequently detected from mild cases in the rest of the years covered by the study (range: 39.4–52.6%). The incidence rates and severity risks of HFMD associated with all serotype categories were the highest for children aged 1 year and younger, and decreased with increasing age. : This study provides baseline epidemiology for evaluation of vaccine impact and potential serotype replacement.

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/content/10.2807/1560-7917.ES.2017.22.50.16-00824
2017-12-14
2024-04-20
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.50.16-00824
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Epidemiology of hand, foot and mouth disease in China, 2008 to 2015 prior to the introduction of EV-A71 vaccine
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Bingyi+Yang&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yang Bingyi</a>, <a href="/search?value1=Fengfeng+Liu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Liu Fengfeng</a>, <a href="/search?value1=Qiaohong+Liao&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Liao Qiaohong</a>, <a href="/search?value1=Peng+Wu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wu Peng</a>, <a href="/search?value1=Zhaorui+Chang&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chang Zhaorui</a>, <a href="/search?value1=Jiao+Huang&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Huang Jiao</a>, <a href="/search?value1=Lu+Long&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Long Lu</a>, <a href="/search?value1=Li+Luo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Luo Li</a>, <a href="/search?value1=Yu+Li&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Li Yu</a>, <a href="/search?value1=Gabriel+M.+Leung&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Leung Gabriel M.</a>, <a href="/search?value1=Benjamin+J.+Cowling&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cowling Benjamin J.</a>, <a href="/search?value1=Hongjie+Yu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yu Hongjie</a></span>. Epidemiology of hand, foot and mouth disease in China, 2008 to 2015 prior to the introduction of EV-A71 vaccine. <a href="/content/ecdc">Euro Surveill.</a> 2017;22(50):pii=16-00824. <a href="https://doi.org/10.2807/1560-7917.ES.2017.22.50.16-00824" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2017.22.50.16-00824</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 22 Dec 2016;&nbsp;&nbsp; <span class="generated">Accepted</span>: 09 Jun 2017 </span> </p>
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