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Abstract

Background

Antimicrobial resistance poses a risk for healthcare, both in the community and hospitals. The spread of multidrug-resistant organisms (MDROs) occurs mostly on a local and regional level, following movement of patients, but also occurs across national borders.

Aim

The aim of this observational study was to determine the prevalence of MDROs in a European cross-border region to understand differences and improve infection prevention based on real-time routine data and workflows.

Methods

Between September 2017 and June 2018, 23 hospitals in the Dutch (NL)–German (DE) cross-border region (BR) participated in the study. During 8 consecutive weeks, patients were screened upon admission to intensive care units (ICUs) for nasal carriage of meticillin-resistant (MRSA) and rectal carriage of vancomycin-resistant / (VRE), third-generation cephalosporin-resistant Enterobacteriaceae (3GCRE) and carbapenem-resistant Enterobacteriaceae (CRE). All samples were processed in the associated laboratories.

Results

A total of 3,365 patients were screened (median age: 68 years (IQR: 57–77); male/female ratio: 59.7/40.3; NL-BR: n = 1,202; DE-BR: n = 2,163). Median screening compliance was 60.4% (NL-BR: 56.9%; DE-BR: 62.9%). MDRO prevalence was higher in DE-BR than in NL-BR, namely 1.7% vs 0.6% for MRSA (p = 0.006), 2.7% vs 0.1% for VRE (p < 0.001) and 6.6% vs 3.6% for 3GCRE (p < 0.001), whereas CRE prevalence was comparable (0.2% in DE-BR vs 0.0% in NL-BR ICUs).

Conclusions

This first prospective multicentre screening study in a European cross-border region shows high heterogenicity in MDRO carriage prevalence in NL-BR and DE-BR ICUs. This indicates that the prevalence is probably influenced by the different healthcare structures.

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2022-02-03
2024-11-01
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2022.27.5.2001660
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A prospective multicentre screening study on multidrug-resistant organisms in intensive care units in the Dutch–German cross-border region, 2017 to 2018: the importance of healthcare structures
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Corinna+Glasner&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Glasner Corinna</a>, <a href="/search?value1=Matthijs+S+Berends&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Berends Matthijs S</a>, <a href="/search?value1=Karsten+Becker&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Becker Karsten</a>, <a href="/search?value1=Jutta+Esser&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Esser Jutta</a>, <a href="/search?value1=Jens+Gieffers&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gieffers Jens</a>, <a href="/search?value1=Annette+Jurke&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jurke Annette</a>, <a href="/search?value1=Greetje+Kampinga&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kampinga Greetje</a>, <a href="/search?value1=Stefanie+Kampmeier&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kampmeier Stefanie</a>, <a href="/search?value1=Rob+Klont&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Klont Rob</a>, <a href="/search?value1=Robin+K%C3%B6ck&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Köck Robin</a>, <a href="/search?value1=Lutz+von+M%C3%BCller&option1=author&noRedirect=true" class="nonDisambigAuthorLink">von Müller Lutz</a>, <a href="/search?value1=Nashwan+al+Naemi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">al Naemi Nashwan</a>, <a href="/search?value1=Alewijn+Ott&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ott Alewijn</a>, <a href="/search?value1=Gijs+Ruijs&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ruijs Gijs</a>, <a href="/search?value1=Katja+Saris&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Saris Katja</a>, <a href="/search?value1=Adriana+Tami&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tami Adriana</a>, <a href="/search?value1=Andreas+Voss&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Voss Andreas</a>, <a href="/search?value1=Karola+Waar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Waar Karola</a>, <a href="/search?value1=Jan+van+Zeijl&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van Zeijl Jan</a>, <a href="/search?value1=Alex+W+Friedrich&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Friedrich Alex W</a></span>. A prospective multicentre screening study on multidrug-resistant organisms in intensive care units in the Dutch–German cross-border region, 2017 to 2018: the importance of healthcare structures. <a href="/content/ecdc">Euro Surveill.</a> 2022;27(5):pii=2001660. <a href="https://doi.org/10.2807/1560-7917.ES.2022.27.5.2001660" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2022.27.5.2001660</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 09 Sept 2020;&nbsp;&nbsp; <span class="generated">Accepted</span>: 17 Mar 2021 </span> </p>
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