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Increase in NDM-1 and NDM-1/OXA-48-producing Klebsiella pneumoniae in Germany associated with the war in Ukraine, 2022
- Mirco Sandfort1,* , Jörg B Hans2,* , Martin A Fischer3,* , Felix Reichert1 , Martina Cremanns2 , Jessica Eisfeld2 , Yvonne Pfeifer3 , Annika Heck1 , Tim Eckmanns1 , Guido Werner3 , Sören Gatermann2 , Sebastian Haller1,** , Niels Pfennigwerth2,**
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View Affiliations Hide AffiliationsAffiliations: 1 Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany 2 German National Reference Centre for Multidrug-resistant Gram-negative Bacteria, Department of Medical Microbiology, Ruhr-University Bochum, Bochum, Germany 3 Department of Infectious Diseases, Robert Koch Institute, Wernigerode, Germany* These authors contributed equally to this article and share first authorship.** These authors contributed equally to this article and share last authorship.Correspondence:Mirco SandfortSandfortM rki.de
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Citation style for this article: Sandfort Mirco, Hans Jörg B, Fischer Martin A, Reichert Felix, Cremanns Martina, Eisfeld Jessica, Pfeifer Yvonne, Heck Annika, Eckmanns Tim, Werner Guido, Gatermann Sören, Haller Sebastian, Pfennigwerth Niels. Increase in NDM-1 and NDM-1/OXA-48-producing Klebsiella pneumoniae in Germany associated with the war in Ukraine, 2022. Euro Surveill. 2022;27(50):pii=2200926. https://doi.org/10.2807/1560-7917.ES.2022.27.50.2200926 Received: 02 Dec 2022; Accepted: 14 Dec 2022
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Abstract
In 2022, German surveillance systems observed rapidly increasing numbers of NDM-1- and NDM-1/OXA-48-producing Klebsiella pneumoniae, which may in part reflect recurring pre-pandemic trends. Among these cases, however, a presence in Ukraine before diagnosis was frequently reported. Whole genome sequencing of 200 isolates showed a high prevalence of sequence types ST147, ST307, ST395 and ST23, including clusters corresponding to clonal dissemination and suggesting onward transmission in Germany. Screening and isolation of patients from Ukraine may help avoid onward transmission.
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