1887
Rapid communication Open Access
Like 0

Abstract

Colistin resistance was detected in 53 of 10,011 (0.5%) by prospective phenotypic testing of consecutive clinical isolates in a single hospital in Barcelona, Spain (2012–15). The gene was retrospectively identified by PCR and sequencing in 15 of 50 available isolates. Each isolate had a unique PFGE pattern except for two. This clonal diversity supports the hypothesis of horizontal dissemination of the gene in the local study population.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2016.21.13.30183
2016-03-31
2024-03-19
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.13.30183
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/21/13/eurosurv-21-30183-2.html?itemId=/content/10.2807/1560-7917.ES.2016.21.13.30183&mimeType=html&fmt=ahah

References

  1. Liu YY, Wang Y, Walsh TR, Yi LX, Zhang R, Spencer J, et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis. 2016;16(2):161-8.  https://doi.org/10.1016/S1473-3099(15)00424-7  PMID: 26603172 
  2. Haenni M, Poirel L, Kieffer N, Châtre P, Saras E, Métayer V, et al. Co-occurrence of extended spectrum β lactamase and MCR-1 encoding genes on plasmids. Lancet Infect Dis. 2016;16(3):281-2.  https://doi.org/10.1016/S1473-3099(16)00007-4  PMID: 26774244 
  3. Hasman H, Hammerum AM, Hansen F, Hendriksen RS, Olesen B, Agersø Y, et al. Detection of mcr-1 encoding plasmid-mediated colistin-resistant Escherichia coli isolates from human bloodstream infection and imported chicken meat, Denmark 2015. Euro Surveill. 2015;20(49):30085.  https://doi.org/10.2807/1560-7917.ES.2015.20.49.30085  PMID: 26676364 
  4. Kluytmans-van den Bergh MF, Huizinga P, Bonten MJ, Bos M, De Bruyne K, Friedrich AW, et al. Presence of mcr-1-positive Enterobacteriaceae in retail chicken meat but not in humans in the Netherlands since 2009. Euro Surveill. 2016;21(9):30149.  https://doi.org/10.2807/1560-7917.ES.2016.21.9.30149  PMID: 26967540 
  5. Skov RL, Monnet DL. Plasmid-mediated colistin resistance (mcr-1 gene): three months later, the story unfolds. Euro Surveill. 2016;21(9):30155.  https://doi.org/10.2807/1560-7917.ES.2016.21.9.30155  PMID: 26967914 
  6. Arcilla MS, van Hattem JM, Matamoros S, Melles DC, Penders J, de Jong MD, et al. Dissemination of the mcr-1 colistin resistance gene. Lancet Infect Dis. 2016;16(2):147-9.  https://doi.org/10.1016/S1473-3099(15)00541-1  PMID: 26711361 
  7. Poirel L, Kieffer N, Liassine N, Thanh D, Nordmann P. Plasmid-mediated carbapenem and colistin resistance in a clinical isolate of Escherichia coli. Lancet Infect Dis. 2016;16(3):281.  https://doi.org/10.1016/S1473-3099(16)00006-2  PMID: 26774246 
  8. Clinical and Laboratory Standards Institute (CLSI). Performance standards for antimicrobial susceptibility testing; twentieth informational supplement. Wayne, PA: CLSI; 2012. CLSI document M100-S22.
  9. European Committee on Antimicrobial Susceptibility Testing (EUCAST). Breakpoint tables for interpretation of MICs and zone diameters. EUCAST; 2016. Available from: http://www.eucast.org/clinical_breakpoints/
  10. Magiorakos AP, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 2012;18(3):268-81.  https://doi.org/10.1111/j.1469-0691.2011.03570.x  PMID: 21793988 
  11. Bradford PA, Kazmierczak KM, Biedenbach DJ, Wise MG, Hackel M, Sahm DF. Correlation of β-lactamase production and colistin resistance among Enterobacteriaceae isolates from a global surveillance program. Antimicrob Agents Chemother. 2015;60(3):1385-92.  https://doi.org/10.1128/AAC.01870-15  PMID: 26666920 
  12. 12Olaitan AO, Morand S, Rolain JM. Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria. Front Microbiol. 2014;5:643.  https://doi.org/10.3389/fmicb.2014.00643  PMID: 25505462 
  13. Olaitan AO, Chabou S, Okdah L, Morand S, Rolain J-M. Dissemination of the mcr-1 colistin resistance gene. Lancet Infect Dis. 2016;16(2):147.  https://doi.org/10.1016/S1473-3099(15)00540-X 
  14. Humphries RM. Susceptibility testing of the polymyxins: where are we now? Pharmacotherapy. 2015;35(1):22-7.  https://doi.org/10.1002/phar.1505  PMID: 25329490 
  15. Catry B, Cavaleri M, Baptiste K, Grave K, Grein K, Holm A, et al. Use of colistin-containing products within the European Union and European Economic Area (EU/EEA): development of resistance in animals and possible impact on human and animal health. Int J Antimicrob Agents. 2015;46(3):297-306.  https://doi.org/10.1016/j.ijantimicag.2015.06.005  PMID: 26215780 
  16. European Medicines Agency (EMA). Sales of veterinary antimicrobial agents in 26 EU/EEA countries in 2013. Fifth ESVAC report ESVAC. EMA/387934/2015. London: EMA; 2015. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Report/2015/10/WC500195687.pdf
  17. de Jong A, Thomas V, Klein U, Marion H, Moyaert H, Simjee S, et al. Pan-European resistance monitoring programmes encompassing food-borne bacteria and target pathogens of food-producing and companion animals. Int J Antimicrob Agents. 2013;41(5):403-9.  https://doi.org/10.1016/j.ijantimicag.2012.11.004  PMID: 23394810 
/content/10.2807/1560-7917.ES.2016.21.13.30183
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error