1887
  1. Home
  2. Eurosurveillance
  3. Volume 22, Issue 5, 02/Feb/2017
  4. Article
Surveillance and outbreak report Open Access
Like 0
Download

Abstract

In eastern Europe, few countries have so far reported laboratory-confirmed cases of lymphogranuloma venereum (LGV). Here we describe 22 LGV cases in men who have sex with men (MSM) detected in Hungary from November 2012 to July 2016. Sequence analyses show that 16 of these 22 cases were affected by the L2c genovariant, with from 2012 to 2014, one LGV L2c case detected per year, followed by seven cases in 2015 and six up to July 2016. Of the 16 total L2c LGV cases, 10 had severe haemorrhagic proctitis. These findings are concerning as cases with this new genovariant among MSM have not been frequently reported in Europe to date. More research is needed to assess the spread of the L2c genovariant and its potential association with virulence and severe clinical manifestation.

© Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Addendum
An addendum has been published for this content:
Addendum for Euro Surveill. 2017; 22(5)
Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2017.22.5.30455
2017-02-02
2024-04-16
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.5.30455
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/22/5/eurosurv-22-5-4.html?itemId=/content/10.2807/1560-7917.ES.2017.22.5.30455&mimeType=html&fmt=ahah

References

  1. European Centre for Disease Prevention and Control (ECDC). Sexually transmitted infections in Europe 2013. Stockholm: ECDC; 2015.
  2. Childs T, Simms I, Alexander S, Eastick K, Hughes G, Field N. Rapid increase in lymphogranuloma venereum in men who have sex with men, United Kingdom, 2003 to September 2015. Euro Surveill. 2015;20(48):30076.  https://doi.org/10.2807/1560-7917.ES.2015.20.48.30076  PMID: 26675210 
  3. Vanousova D, Zakoucka H, Jilich D, Rozsypal H, Stankova M, Zufanova S, et al. First detection of Chlamydia trachomatis LGV biovar in the Czech Republic, 2010-2011. Euro Surveill. 2012;17(2):20055. PMID: 22264863 
  4. Balla E, Petrovay F, Mag T, Balázs A, Erdősi T, Együd K, et al. Confirmed cases of lymphogranuloma venereum in Hungary, 2012-2014: supportive diagnostic tool of immunoblotting. Sex Transm Infect. 2015;91(3):200.  https://doi.org/10.1136/sextrans-2014-051673  PMID: 25887854 
  5. Matičič M, Klavs I, Videčnik Zorman J, Vidmar Vovko D, Kogoj R, Keše D. Confirmed inguinal lymphogranuloma venereum genovar L2c in a man who had sex with men, Slovenia, 2015. Euro Surveill. 2016;21(5):30129.  https://doi.org/10.2807/1560-7917.ES.2016.21.5.30129  PMID: 26889644 
  6. Rob F, Jůzlová K, Krutáková H, Zákoucká H, Vaňousová D, Kružicová Z, et al. Steady increase of lymphogranuloma venereum cases, Czech Republic, 2010 to 2015. Euro Surveill. 2016;21(11):30165.  https://doi.org/10.2807/1560-7917.ES.2016.21.11.30165  PMID: 27020297 
  7. Christerson L, de Vries HJ, de Barbeyrac B, Gaydos CA, Henrich B, Hoffmann S, et al. Typing of lymphogranuloma venereum Chlamydia trachomatis strains. Emerg Infect Dis. 2010;16(11):1777-9.  https://doi.org/10.3201/eid1611.100379  PMID: 21029543 
  8. Parra-Sánchez M, García-Rey S, Pueyo Rodríguez I, Viciana Fernández P, Torres Sánchez MJ, Palomares Folía JC. Clinical and epidemiological characterisation of lymphogranuloma venereum in southwest Spain, 2013-2015. Sex Transm Infect. 2016;92(8):629-31.  https://doi.org/10.1136/sextrans-2015-052453  PMID: 27288416 
  9. de Vries HJ, van der Bij AK, Fennema JS, Smit C, de Wolf F, Prins M, et al. Lymphogranuloma venereum proctitis in men who have sex with men is associated with anal enema use and high-risk behavior. Sex Transm Dis. 2008;35(2):203-8.  https://doi.org/10.1097/OLQ.0b013e31815abb08  PMID: 18091565 
  10. Somboonna N, Wan R, Ojcius DM, Pettengill MA, Joseph SJ, Chang A, et al. Hypervirulent Chlamydia trachomatis clinical strain is a recombinant between lymphogranuloma venereum (L(2)) and D lineages. MBio. 2011;2(3):e00045-11.  https://doi.org/10.1128/mBio.00045-11  PMID: 21540364 
  11. de Vries HJ, Zingoni A, Kreuter A, Moi H, White JAEuropean Branch of the International Union against Sexually Transmitted InfectionsEuropean Academy of Dermatology and VenereologyEuropean Dermatology ForumEuropean Society of Clinical Microbiology and Infectious DiseasesUnion of European Medical SpecialistsEuropean Centre for Disease Prevention and ControlEuropean Office of the World Health Organisation. 2013 European guideline on the management of lymphogranuloma venereum. J Eur Acad Dermatol Venereol. 2015;29(1):1-6.  https://doi.org/10.1111/jdv.12461  PMID: 24661352 
  12. Stary G, Meyer T, Bangert C, Kohrgruber N, Gmeinhart B, Kirnbauer R, et al. New Chlamydia trachomatis L2 strains identified in a recent outbreak of lymphogranuloma venereum in Vienna, Austria. Sex Transm Dis. 2008;35(4):377-82.  https://doi.org/10.1097/OLQ.0b013e31815d6df8  PMID: 18209688 
  13. Morré SA, Spaargaren J, Fennema JS, de Vries HJ, Coutinho RA, Peña AS. Real-time polymerase chain reaction to diagnose lymphogranuloma venereum. Emerg Infect Dis. 2005;11(8):1311-2.  https://doi.org/10.3201/eid1108.050535  PMID: 16110579 
  14. Petrovay F, Balla E, Németh I, Gönczöl E. Genotyping of Chlamydia trachomatis from the endocervical specimens of high-risk women in Hungary. J Med Microbiol. 2009;58(Pt 6):760-4.  https://doi.org/10.1099/jmm.0.008607-0  PMID: 19429752 
  15. Peuchant O, Touati A, Sperandio C, Hénin N, Laurier-Nadalié C, Bébéar C, et al. Changing Pattern of Chlamydia trachomatis Strains in Lymphogranuloma Venereum Outbreak, France, 2010-2015. Emerg Infect Dis. 2016;22(11):1945-7.  https://doi.org/10.3201/eid2211.160247  PMID: 27767927 
  16. Ward H, Alexander S, Carder C, Dean G, French P, Ivens D, et al. The prevalence of lymphogranuloma venereum infection in men who have sex with men: results of a multicentre case finding study. Sex Transm Infect. 2009;85(3):173-5.  https://doi.org/10.1136/sti.2008.035311  PMID: 19221105 
  17. Rodríguez-Domínguez M, Puerta T, Menéndez B, González-Alba JM, Rodríguez C, Hellín T, et al. Clinical and epidemiological characterization of a lymphogranuloma venereum outbreak in Madrid, Spain: co-circulation of two variants. Clin Microbiol Infect. 2014;20(3):219-25.  https://doi.org/10.1111/1469-0691.12256  PMID: 23730727 
Emergence of the lymphogranuloma venereum L2c genovariant, Hungary, 2012 to 2016
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Fruzsina+Petrovay&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Petrovay Fruzsina</a>, <a href="/search?value1=Eszter+Balla&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Balla Eszter</a>, <a href="/search?value1=T%C3%ADmea+Erd%C5%91si&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Erdősi Tímea</a></span>. Emergence of the lymphogranuloma venereum L2c genovariant, Hungary, 2012 to 2016 . <a href="/content/ecdc">Euro Surveill.</a> 2017;22(5):pii=30455. <a href="https://doi.org/10.2807/1560-7917.ES.2017.22.5.30455" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2017.22.5.30455</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 26 Sept 2016;&nbsp;&nbsp; <span class="generated">Accepted</span>: 20 Jan 2017 </span> </p>
/content/10.2807/1560-7917.ES.2017.22.5.30455
/content/10.2807/1560-7917.ES.2017.22.5.30455
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error