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Abstract

Hepatitis B prevention in European Union/European Economic Area (EU/EEA) countries relies on vaccination programmes. We describe the epidemiology of acute hepatitis B virus (HBV) at country and EU/EEA level during 2006–2014. Using a multi-level mixed-effects Poisson regression model we assessed differences in the acute HBV infection notification rates between groups of countries that started universal HBV vaccination before/in vs after 1995; implemented or not a catch-up strategy; reached a vaccine coverage ≥ 95% vs < 95% and had a hepatitis B surface antigen prevalence ≥ 1% vs < 1%. Joinpoint regression analysis was used to assess trends by groups of countries, and additional Poisson regression models to evaluate the association between three-dose HBV vaccine coverage and acute HBV infection notification rates at country and EU/EEA level. The EU/EEA acute HBV infection notification rate decreased from 1.6 per 100,000 population in 2006 to 0.7 in 2014. No differences (p > 0.05) were found in the acute HBV infection notification rates between groups of countries, while as vaccine coverage increased, such rates decreased (p < 0.01). Countries with universal HBV vaccination before 1995, a catch-up strategy, and a vaccine coverage ≥ 95% had significant decreasing trends (p < 0.01). Ending HBV transmission in Europe by 2030 will require high vaccine coverage delivered through universal programmes, supported, where appropriate, by catch-up vaccination campaigns.

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/content/10.2807/1560-7917.ES.2018.23.6.17-00278
2018-02-08
2024-04-16
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2018.23.6.17-00278
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Impact of hepatitis B vaccination on acute hepatitis B epidemiology in European Union/European Economic Area countries, 2006 to 2014
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Alessandro+Miglietta&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Miglietta Alessandro</a>, <a href="/search?value1=Chantal+Quinten&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Quinten Chantal</a>, <a href="/search?value1=Pier+Luigi+Lopalco&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lopalco Pier Luigi</a>, <a href="/search?value1=Erika+Duffell&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Duffell Erika</a></span>. Impact of hepatitis B vaccination on acute hepatitis B epidemiology in European Union/European Economic Area countries, 2006 to 2014. <a href="/content/ecdc">Euro Surveill.</a> 2018;23(6):pii=17-00278. <a href="https://doi.org/10.2807/1560-7917.ES.2018.23.6.17-00278" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2018.23.6.17-00278</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 19 Apr 2017;&nbsp;&nbsp; <span class="generated">Accepted</span>: 03 Jan 2018 </span> </p>
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