1887
  1. Home
  2. Eurosurveillance
  3. Volume 25, Issue 46, 19/Nov/2020
  4. Article
Rapid communication Open Access
Like 0
Download

Abstract

Following a distinct summer heat wave, nine autochthonous cases of West Nile fever and West Nile neuroinvasive disease, including one fatality, were observed in Leipzig, Germany, in August and September 2020. Phylogenetic analysis demonstrated close relationships in viruses from humans, animals and mosquitos in eastern Germany, obtained during the preceding 2 years. The described large cluster of autochthonous West Nile virus infections in Germany indicates endemic seasonal circulation of lineage 2 viruses in the area.

© Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2020.25.46.2001786
2020-11-19
2024-11-01
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.46.2001786
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/25/46/eurosurv-25-46-2.html?itemId=/content/10.2807/1560-7917.ES.2020.25.46.2001786&mimeType=html&fmt=ahah

References

  1. European Commission. European Commission implementing decision of 8 August 2012 amending Decision 2002/253/EC laying down case definitions for reporting communicable diseases to the Community network under Decision No 2119/98/EC of the European Parliament and of the Council. 27.9.2012:L 262. Official Journal of the European Union. Luxembourg: Publications Office of the European Union. 27 Sep 2012. Available from: http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2012:262:0001:0057:EN:PDF
  2. Eiden M, Vina-Rodriguez A, Hoffmann B, Ziegler U, Groschup MH. Two new real-time quantitative reverse transcription polymerase chain reaction assays with unique target sites for the specific and sensitive detection of lineages 1 and 2 West Nile virus strains. Journal of veterinary diagnostic investigation: official publication of the American Association of Veterinary Laboratory Diagnosticians. Inc.2010;22(5):748-53.
  3. Barzon L, Pacenti M, Franchin E, Squarzon L, Sinigaglia A, Ulbert S, et al. Isolation of West Nile virus from urine samples of patients with acute infection. J Clin Microbiol. 2014;52(9):3411-3.  https://doi.org/10.1128/JCM.01328-14  PMID: 24951801 
  4. Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S. MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol. 2011;28(10):2731-9.  https://doi.org/10.1093/molbev/msr121  PMID: 21546353 
  5. Gray TJ, Webb CE. A review of the epidemiological and clinical aspects of West Nile virus. Int J Gen Med. 2014;7:193-203.  https://doi.org/10.2147/IJGM.S59902  PMID: 24748813 
  6. Bakonyi T, Hubálek Z, Rudolf I, Nowotny N. Novel flavivirus or new lineage of West Nile virus, central Europe. Emerg Infect Dis. 2005;11(2):225-31.  https://doi.org/10.3201/eid1102.041028  PMID: 15752439 
  7. Camp JV, Nowotny N. The knowns and unknowns of West Nile virus in Europe: what did we learn from the 2018 outbreak? Expert Rev Anti Infect Ther. 2020;18(2):145-54.  https://doi.org/10.1080/14787210.2020.1713751  PMID: 31914833 
  8. Bakonyi T, Ferenczi E, Erdélyi K, Kutasi O, Csörgő T, Seidel B, et al. Explosive spread of a neuroinvasive lineage 2 West Nile virus in Central Europe, 2008/2009. Vet Microbiol. 2013;165(1-2):61-70.  https://doi.org/10.1016/j.vetmic.2013.03.005  PMID: 23570864 
  9. Schultze-Amberger J, Emmerich P, Günther S, Schmidt-Chanasit J. West Nile virus meningoencephalitis imported into Germany. Emerg Infect Dis. 2012;18(10):1698-700.  https://doi.org/10.3201/eid1810.120204  PMID: 23017806 
  10. Pietsch C, Trawinski H, Lübbert C, Liebert UG. Short Communication: West Nile fever imported from Austria to Germany. Transbound Emerg Dis. 2019;66(2):1033-6.  https://doi.org/10.1111/tbed.13079  PMID: 30462884 
  11. Ziegler U, Lühken R, Keller M, Cadar D, van der Grinten E, Michel F, et al. West Nile virus epizootic in Germany, 2018. Antiviral Res. 2019;162:39-43.  https://doi.org/10.1016/j.antiviral.2018.12.005  PMID: 30550796 
  12. Michel F, Sieg M, Fischer D, Keller M, Eiden M, Reuschel M, et al. Evidence for West Nile Virus and Usutu Virus Infections in Wild and Resident Birds in Germany, 2017 and 2018. Viruses. 2019;11(7):E674.  https://doi.org/10.3390/v11070674  PMID: 31340516 
  13. Michel F, Fischer D, Eiden M, Fast C, Reuschel M, Müller K, et al. West Nile Virus and Usutu Virus Monitoring of Wild Birds in Germany. Int J Environ Res Public Health. 2018;15(1):E171.  https://doi.org/10.3390/ijerph15010171  PMID: 29361762 
  14. Scheuch DE, Schäfer M, Eiden M, Heym EC, Ziegler U, Walther D, et al. Detection of Usutu, Sindbis, and Batai Viruses in Mosquitoes (Diptera: Culicidae) Collected in Germany, 2011−2016. Viruses. 2018;10(7):E389.  https://doi.org/10.3390/v10070389  PMID: 30041410 
  15. Heym EC, Kampen H, Krone O, Schäfer M, Werner D. Molecular detection of vector-borne pathogens from mosquitoes collected in two zoological gardens in Germany. Parasitol Res. 2019;118(7):2097-105.  https://doi.org/10.1007/s00436-019-06327-5  PMID: 31154526 
  16. Ziegler U, Fischer D, Eiden M, Reuschel M, Rinder M, Müller K, et al. Sindbis virus- a wild bird associated zoonotic arbovirus circulates in Germany. Vet Microbiol. 2019;239:108453.  https://doi.org/10.1016/j.vetmic.2019.108453  PMID: 31767092 
  17. Ziegler U, Santos PD, Groschup MH, Hattendorf C, Eiden M, Höper D, et al. West Nile Virus Epidemic in Germany Triggered by Epizootic Emergence, 2019. Viruses. 2020;12(4):E448.  https://doi.org/10.3390/v12040448  PMID: 32326472 
  18. Kampen H, Holicki CM, Ziegler U, Groschup MH, Tews BA, Werner D. West Nile Virus Mosquito Vectors (Diptera: Culicidae) in Germany. Viruses. 2020;12(5):E493.  https://doi.org/10.3390/v12050493  PMID: 32354202 
  19. Holicki CM, Ziegler U, Răileanu C, Kampen H, Werner D, Schulz J, et al. West Nile Virus Lineage 2 Vector Competence of Indigenous Culex and Aedes Mosquitoes from Germany at Temperate Climate Conditions. Viruses. 2020;12(5):12.  https://doi.org/10.3390/v12050561  PMID: 32438619 
  20. Paull SH, Horton DE, Ashfaq M, Rastogi D, Kramer LD, Diffenbaugh NS, et al. Drought and immunity determine the intensity of West Nile virus epidemics and climate change impacts. Proceedings Biological sciences / The Royal Society.1848;2017:284.
  21. Robert Koch Institute (RKI). Aktuelle Situation zu autochthonen menschlichen Infektionen mit dem West-Nil-Virus in Deutschland 2020. [Current situation of autochthonous human infections with West Nile virus in Germany 2020]. Epid Bull. 2020;37. German. Available from: https://www.rki.de/DE/Content/Infekt/EpidBull/Archiv/2020/Ausgaben/37_20.pdf?__blob=publicationFile
Autochthonous West Nile virus infection outbreak in humans, Leipzig, Germany, August to September 2020
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Corinna+Pietsch&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pietsch Corinna</a>, <a href="/search?value1=Dominik+Michalski&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Michalski Dominik</a>, <a href="/search?value1=Johannes+M%C3%BCnch&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Münch Johannes</a>, <a href="/search?value1=Sirak+Petros&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Petros Sirak</a>, <a href="/search?value1=Sandra+Bergs&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bergs Sandra</a>, <a href="/search?value1=Henning+Trawinski&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Trawinski Henning</a>, <a href="/search?value1=Christoph+L%C3%BCbbert&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lübbert Christoph</a>, <a href="/search?value1=Uwe+G+Liebert&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Liebert Uwe G</a></span>. Autochthonous West Nile virus infection outbreak in humans, Leipzig, Germany, August to September 2020. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(46):pii=2001786. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.46.2001786" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.46.2001786</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 14 Oct 2020;&nbsp;&nbsp; <span class="generated">Accepted</span>: 18 Nov 2020 </span> </p>
/content/10.2807/1560-7917.ES.2020.25.46.2001786
/content/10.2807/1560-7917.ES.2020.25.46.2001786
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error