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Abstract

An influenza A(H1N1)pdm09 virus carrying a G147R substitution in combination with an H275Y substitution in the neuraminidase protein, which confers cross-resistance to oseltamivir and peramivir, was detected from an immunocompromised inpatient in Japan, March 2016. This dual H275Y/G147R mutant virus exhibited enhanced cross-resistance to both drugs compared with the single H275Y mutant virus and reduced susceptibility to zanamivir, although it showed normal inhibition by laninamivir.

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/content/10.2807/1560-7917.ES.2016.21.24.30258
2016-06-16
2017-11-19
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.24.30258
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