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Abstract

An influenza A(H1N1)pdm09 virus carrying a G147R substitution in combination with an H275Y substitution in the neuraminidase protein, which confers cross-resistance to oseltamivir and peramivir, was detected from an immunocompromised inpatient in Japan, March 2016. This dual H275Y/G147R mutant virus exhibited enhanced cross-resistance to both drugs compared with the single H275Y mutant virus and reduced susceptibility to zanamivir, although it showed normal inhibition by laninamivir.

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/content/10.2807/1560-7917.ES.2016.21.24.30258
2016-06-16
2018-04-27
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.24.30258
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Influenza A(H1N1)pdm09 virus exhibiting enhanced cross-resistance to oseltamivir and peramivir due to a dual H275Y/G147R substitution, Japan, March 2016
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Emi+Takashita&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Takashita Emi</a>, <a href="/search?value1=Seiichiro+Fujisaki&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fujisaki Seiichiro</a>, <a href="/search?value1=Masayuki+Shirakura&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Shirakura Masayuki</a>, <a href="/search?value1=Kazuya+Nakamura&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nakamura Kazuya</a>, <a href="/search?value1=Noriko+Kishida&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kishida Noriko</a>, <a href="/search?value1=Tomoko+Kuwahara&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kuwahara Tomoko</a>, <a href="/search?value1=Yukie+Shimazu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Shimazu Yukie</a>, <a href="/search?value1=Takeshi+Shimomura&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Shimomura Takeshi</a>, <a href="/search?value1=Shinji+Watanabe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Watanabe Shinji</a>, <a href="/search?value1=Takato+Odagiri&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Odagiri Takato</a>, <a href="/search?value1=The+Influenza+Virus+Surveillance+Group+of+Japan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">The Influenza Virus Surveillance Group of Japan</a></span>. Influenza A(H1N1)pdm09 virus exhibiting enhanced cross-resistance to oseltamivir and peramivir due to a dual H275Y/G147R substitution, Japan, March 2016. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(24):pii=30258. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.24.30258" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.24.30258</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 20 May 2016;&nbsp;&nbsp; <span class="generated">Accepted</span>: 16 Jun 2016 </span> </p>
/content/10.2807/1560-7917.ES.2016.21.24.30258
/content/10.2807/1560-7917.ES.2016.21.24.30258
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