1887
Research article Open Access
Like 0

Abstract

The geographical risk areas for tick-borne encephalitis (TBE) in Finland remained the same until the beginning of the 21st century, but a considerable geographical expansion has been observed in the past 10 years. In order to support public health measures, the present study describes the number of laboratory-confirmed TBE cases and laboratory tests conducted and the associated trends by hospital district, with a particular emphasis on the suspected geographical risk areas. An additional investigation was conducted on 1,957 clinical serum samples throughout the country taken from patients with neurological symptoms to screen for undiagnosed TBE cases. This study identified new TBE foci in Finland, reflecting the spread of the disease into new areas. Even in the most endemic municipalities, transmission of TBE to humans occurred in very specific and often small foci. The number of antibody tests for TBE virus more than doubled (an increase by 105%) between 2007 and 2013. Analysis of the number of tests also revealed areas in which the awareness of clinicians may be suboptimal at present. However, it appears that underdiagnosis of neuroinvasive TBE is not common.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2015.20.37.30020
2015-09-17
2024-04-24
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2015.20.37.30020
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/20/37/eurosurv-20-30020-4.html?itemId=/content/10.2807/1560-7917.ES.2015.20.37.30020&mimeType=html&fmt=ahah

References

  1. Lindquist L, Vapalahti O. Tick-borne encephalitis. Lancet. 2008;371(9627):1861-71.  https://doi.org/10.1016/S0140-6736(08)60800-4  PMID: 18514730 
  2. Süss J. Tick-borne encephalitis 2010: epidemiology, risk areas, and virus strains in Europe and Asia-an overview. Ticks Tick Borne Dis. 2011;2(1):2-15.  https://doi.org/10.1016/j.ttbdis.2010.10.007  PMID: 21771531 
  3. Randolph SE, Rogers DJ. Fragile transmission cycles of tick-borne encephalitis virus may be disrupted by predicted climate change. Proc Biol Sci. 2000;267(1454):1741-4.  https://doi.org/10.1098/rspb.2000.1204  PMID: 12233771 
  4. Tonteri E, Jääskeläinen AE, Tikkakoski T, Voutilainen L, Niemimaa J, Henttonen H, et al. Tick-borne encephalitis virus in wild rodents in winter, Finland, 2008-2009. Emerg Infect Dis. 2011;17(1):72-5.  https://doi.org/10.3201/eid1701.100051  PMID: 21192857 
  5. Tonteri E, Kipar A, Voutilainen L, Vene S, Vaheri A, Vapalahti O, et al. The Three Subtypes of Tick-Borne Encephalitis Virus Induce Encephalitis in a Natural Host, the Bank Vole (Myodes glareolus). PLoS One. 2013;8(12):e81214.
  6. Krasnov BR, Stanko M, Morand S. Host community structure and infestation by ixodid ticks: repeatability, dilution effect and ecological specialization. Oecologia. 2007;154(1):185-94.  https://doi.org/10.1007/s00442-007-0824-x  PMID: 17684769 
  7. Růžek D, Dobler G, Donoso Mantke O. Tick-borne encephalitis: pathogenesis and clinical implications. Travel Med Infect Dis. 2010;8(4):223-32.  https://doi.org/10.1016/j.tmaid.2010.06.004  PMID: 20970725 
  8. Wahlberg P, Saikku P, Brummer-Korvenkontio M. Tick-borne viral encephalitis in Finland. The clinical features of Kumlinge disease during 1959-1987. J Intern Med. 1989;225(3):173-7.  https://doi.org/10.1111/j.1365-2796.1989.tb00059.x  PMID: 2703799 
  9. Haglund M, Günther G. Tick-borne encephalitis--pathogenesis, clinical course and long-term follow-up. Vaccine. 2003;21(Suppl 1):S11-8.  https://doi.org/10.1016/S0264-410X(02)00811-3  PMID: 12628810 
  10. Holzmann H. Diagnosis of tick-borne encephalitis. Vaccine. 2003;21(Suppl 1):S36-40.  https://doi.org/10.1016/S0264-410X(02)00819-8  PMID: 12628812 
  11. Gunther G, Haglund M, Lindquist L, Sköldenberg B, Forsgren M. Intrathecal IgM, IgA and IgG antibody response in tick-borne encephalitis. Long-term follow-up related to clinical course and outcome. Clin Diagn Virol. 1997;8(1):17-29.
  12. Jääskeläinen AE, Sironen T, Murueva GB, Subbotina N, Alekseev AN, Castrén J, et al. Tick-borne encephalitis virus in ticks in Finland, Russian Karelia and Buryatia. J Gen Virol. 2010;91(Pt 11):2706-12.  https://doi.org/10.1099/vir.0.023663-0  PMID: 20660147 
  13. Jääskeläinen AE, Tikkakoski T, Uzcátegui NY, Alekseev AN, Vaheri A, Vapalahti O. Siberian subtype tickborne encephalitis virus, Finland. Emerg Infect Dis. 2006;12(10):1568-71.  https://doi.org/10.3201/eid1210.060320  PMID: 17176574 
  14. Jääskeläinen AE, Tonteri E, Sironen T, Pakarinen L, Vaheri A, Vapalahti O. European subtype tick-borne encephalitis virus in Ixodes persulcatus ticks. Emerg Infect Dis. 2011;17(2):323-5.  https://doi.org/10.3201/eid1702.101487  PMID: 21291624 
  15. Han X, Juceviciene A, Uzcategui NY, Brummer-Korvenkontio H, Zygutiene M, Jääskeläinen A, et al. Molecular epidemiology of tick-borne encephalitis virus in Ixodes ricinus ticks in Lithuania. J Med Virol. 2005;77(2):249-56.  https://doi.org/10.1002/jmv.20444  PMID: 16121364 
  16. Jaaskelainen A, Korhonen T, Kuusi M, Vapalahti O. Tick-borne encephalitis in Finland. EpiNorth 2011(12):40-43.
  17. Golovljova I, Vene S, Sjölander KB, Vasilenko V, Plyusnin A, Lundkvist A. Characterization of tick-borne encephalitis virus from Estonia. J Med Virol. 2004;74(4):580-8.  https://doi.org/10.1002/jmv.20224  PMID: 15484275 
  18. Katargina O, Russakova S, Geller J, Kondrusik M, Zajkowska J, Zygutiene M, et al. Detection and characterization of tick-borne encephalitis virus in Baltic countries and eastern Poland. PLoS One. 2013;8(5):e61374.  https://doi.org/10.1371/journal.pone.0061374  PMID: 23650497 
  19. Lundkvist k, Vene S, Golovljova I, Mavtchoutko V, Forsgren M, Kalnina V, et al. Characterization of tick-borne encephalitis virus from Latvia: evidence for co-circulation of three distinct subtypes. J Med Virol. 2001;65(4):730-735.
  20. Oker-Blom N. Kumlinge disease; a meningo-encephalitis occurring in the Aaland Islands. Ann Med Exp Biol Fenn. 1956;34(3):309-18.
  21. European Commission. Commission implementing decision (2012/506/EU) of 8 August 2012 amending Decision 2002/253/EC laying down case definitions for reporting communicable diseases to the Community network under Decision No 2119/98/EC of the European Parliament and of the Council. Official Journal of the European Union. Luxembourg: Publications Office of the European Union. 27.9.2012. Available from: http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2012:262:0001:0057:EN:PDF
  22. Jääskeläinen A, Han X, Niedrig M, Vaheri A, Vapalahti O. Diagnosis of tick-borne encephalitis by a mu-capture immunoglobulin M-enzyme immunoassay based on secreted recombinant antigen produced in insect cells. J Clin Microbiol. 2003;41(9):4336-42.  https://doi.org/10.1128/JCM.41.9.4336-4342.2003  PMID: 12958266 
  23. Niedrig M, Klockmann U, Lang W, Roeder J, Burk S, Modrow S, et al. Monoclonal antibodies directed against tick-borne encephalitis virus with neutralizing activity in vivo. Acta Virol. 1994;38(3):141-149.
  24. Vene S, Haglund M, Vapalahti O, Lundkvist A. A rapid fluorescent focus inhibition test for detection of neutralizing antibodies to tick-borne encephalitis virus. J Virol Methods. 1998;73(1):71-5.  https://doi.org/10.1016/S0166-0934(98)00041-X  PMID: 9705177 
  25. Population by sex and area 31.12.2014 and increase of population. Helsinki: Statistics Finland. [Accessed: 31 Aug 2015]. Available from: http://pxnet2.stat.fi/PXWeb/pxweb/en/StatFin/StatFin__vrm__vaerak/010_vaerak_tau_123.px/?rxid=c9c51d56-e1dd-441e-8adb-8e7a2f766f61
  26. Wahlberg P, Carlsson SA, Granlund H, Jansson C, Lindén M, Nyberg C, et al. TBE in Aland Islands 1959-2005: Kumlinge disease. Scand J Infect Dis. 2006;38(11-12):1057-62.  https://doi.org/10.1080/00365540600868297  PMID: 17148077 
  27. National institute of health and welfare (THL). Terveyden ja hyvinvoinnin laitos (THL). Pitäisikö TBE-rokotusohjelmaa laajentaa? Puutiaisaivokuumerokotusryöryhmän raportti. [Should the TBE vaccination programme be expanded? Report of the tick-borne encephalitis vaccine working group]. Työpaperi. 2013;44:1-49. Finnish. Available from: http://www.julkari.fi/bitstream/handle/10024/110860/URN_ISBN_978-952-245-627-4.pdf?sequence=1
  28. Andersson CR, Vene S, Insulander M, Lindquist L, Lundkvist A, Günther G. Vaccine failures after active immunisation against tick-borne encephalitis. Vaccine. 2010;28(16):2827-31.  https://doi.org/10.1016/j.vaccine.2010.02.001  PMID: 20167301 
  29. Lindblom P, Wilhelmsson P, Fryland L, Matussek A, Haglund M, Sjöwall J, et al. Factors determining immunological response to vaccination against tick-borne encephalitis virus in older individuals. PLoS ONE. 2014;9(6):e100860.  https://doi.org/10.1371/journal.pone.0100860  PMID: 24967619 
  30. Mitzel DN, Best SM, Masnick MF, Porcella SF, Wolfinbarger JB, Bloom ME. Identification of genetic determinants of a tick-borne flavivirus associated with host-specific adaptation and pathogenicity. Virology. 2008;381(2):268-76.  https://doi.org/10.1016/j.virol.2008.08.030  PMID: 18823640 
  31. Summerhouses 2013. Helsinki: Statistics Finland. [Accessed: 6 Apr 2014]. Available from: http://tilastokeskus.fi/til/rakke/2013/rakke_2013_2014-05-23_kat_001_fi.html
  32. Lindblom P, Wilhelmsson P, Fryland L, Sjöwall J, Haglund M, Matussek A, et al. Tick-borne encephalitis virus in ticks detached from humans and follow-up of serological and clinical response. Ticks Tick Borne Dis. 2014;5(1):21-8.  https://doi.org/10.1016/j.ttbdis.2013.07.009  PMID: 24275477 
  33. Sumilo D, Asokliene L, Bormane A, Vasilenko V, Golovljova I, Randolph SE. Climate change cannot explain the upsurge of tick-borne encephalitis in the Baltics. PLoS ONE. 2007;2(6):e500.  https://doi.org/10.1371/journal.pone.0000500  PMID: 17551580 
  34. Tokarevich N, Tronin A, Blinova O, Buzinov R, Boltenkov V, Yurasova E, et al. The impact of climate change on the expansion of Ixodes persulcatus habitat and the incidence of tick-borne encephalitis in the north of European Russia. Global Health Action, 2011, Vol 4 2011;4.
  35. Gray JS, Dautel H, Estrada-Pena A, Kahl O, Lindgren E. Effects of climate change on ticks and tick-borne diseases in europe. Interdiscip Perspect Infect Dis. 2009;593232.
  36. Jaenson TG, Jaenson DG, Eisen L, Petersson E, Lindgren E. Changes in the geographical distribution and abundance of the tick Ixodes ricinus during the past 30 years in Sweden. Parasit Vectors. 2012;5(1):8-22.  https://doi.org/10.1186/1756-3305-5-8  PMID: 22233771 
  37. Danielová V, Schwarzová L, Materna J, Daniel M, Metelka L, Holubová J, et al. Tick-borne encephalitis virus expansion to higher altitudes correlated with climate warming. Int J Med Microbiol. 2008;298(S1):68-72.
  38. Gray JS, Dautel H, Estrada-Peña A, Kahl O, Lindgren E. Effects of climate change on ticks and tick-borne diseases in europe. Interdiscip Perspect Infect Dis. 2009;2009:593232.  https://doi.org/10.1155/2009/593232  PMID: 19277106 
  39. Sumilo D, Bormane A, Asokliene L, Vasilenko V, Golovljova I, Avsic-Zupanc T, et al. Socio-economic factors in the differential upsurge of tick-borne encephalitis in Central and Eastern Europe. Rev Med Virol. 2008;18(2):81-95.  https://doi.org/10.1002/rmv.566  PMID: 18183571 
  40. Tuomi J, Brummer-Korvenkontio M. Antibodies against viruses of the tick-borne encephalitis group in cattle sera in Finland. Ann Med Exp Biol Fenn. 1965;43(3):149-54.
  41. Tartuntatautirekisteri. [Infectious Diseases Register]. Helsinki: National Institute for Health and Welfare. [Accessed: 5 Feb 2015]. Finnish. Available from: http://www.thl.fi/fi_FI/web/infektiotaudit-fi/tartuntatautirekisteri
/content/10.2807/1560-7917.ES.2015.20.37.30020
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error