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Abstract

Plaque reduction neutralisation tests (PRNT), microneutralisation (MN), Middle East respiratory syndrome (MERS)-spike pseudoparticle neutralisation (ppNT) and MERS S1-enzyme-linked immunosorbent assay (ELISA) antibody titres were compared using 95 sera from 17 patients with MERS, collected two to 46 days after symptom onset. Neutralisation tests correlated well with each other and moderately well with S1 ELISA. Moreover to compare antigenic similarity of genetically diverse MERS-CoV clades, the response of four sera from two patients sampled at two time periods during the course of illness were tested by 90% PRNT. Genetically diverse MERS-CoV clades were antigenically homogenous.

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/content/10.2807/1560-7917.ES.2015.20.41.30042
2015-10-15
2024-09-12
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2015.20.41.30042
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Comparison of serological assays in human Middle East respiratory syndrome (MERS)-coronavirus infection
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Sang+Won+Park&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Park Sang Won</a>, <a href="/search?value1=Ranawaka+A+P+M+Perera&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Perera Ranawaka A P M</a>, <a href="/search?value1=Pyoeng+Gyun+Choe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Choe Pyoeng Gyun</a>, <a href="/search?value1=Eric+H+Y+Lau&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lau Eric H Y</a>, <a href="/search?value1=Seong+Jin+Choi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Choi Seong Jin</a>, <a href="/search?value1=June+Young+Chun&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chun June Young</a>, <a href="/search?value1=Hong+Sang+Oh&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Oh Hong Sang</a>, <a href="/search?value1=Kyoung-Ho+Song&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Song Kyoung-Ho</a>, <a href="/search?value1=Ji+Hwan+Bang&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bang Ji Hwan</a>, <a href="/search?value1=Eu+Suk+Kim&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kim Eu Suk</a>, <a href="/search?value1=Hong+Bin+Kim&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kim Hong Bin</a>, <a href="/search?value1=Wan+Beom+Park&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Park Wan Beom</a>, <a href="/search?value1=Nam+Joong+Kim&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kim Nam Joong</a>, <a href="/search?value1=Leo+Lit+Man++Poon&option1=author&noRedirect=true" class="nonDisambigAuthorLink"> Poon Leo Lit Man</a>, <a href="/search?value1=Malik+Peiris&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Peiris Malik</a>, <a href="/search?value1=Myoung+Don+Oh&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Oh Myoung Don</a></span>. Comparison of serological assays in human Middle East respiratory syndrome (MERS)-coronavirus infection. <a href="/content/ecdc">Euro Surveill.</a> 2015;20(41):pii=30042. <a href="https://doi.org/10.2807/1560-7917.ES.2015.20.41.30042" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2015.20.41.30042</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 14 Sept 2015;&nbsp;&nbsp; <span class="generated">Accepted</span>: 15 Oct 2015 </span> </p>
/content/10.2807/1560-7917.ES.2015.20.41.30042
/content/10.2807/1560-7917.ES.2015.20.41.30042
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