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Real-time safety surveillance of seasonal influenza vaccines in children, Australia, 2015
- Alexis Pillsbury1 , Patrick Cashman2,3 , Alan Leeb4 , Annette Regan5,6 , Darren Westphal5,7,8 , Tom Snelling7,9 , Christopher Blyth7,9,10 , Nigel Crawford11,12,13 , Nicholas Wood1,14 , Kristine Macartney1,2,15 , on behalf of the AusVaxSafety 16
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View Affiliations Hide AffiliationsAffiliations: 1 National Centre for Immunisation Research and Surveillance, The Children’s Hospital at Westmead, NSW, Australia 2 Hunter New England Local Health District, NSW, Australia 3 The University of Newcastle, NSW, Australia 4 Illawarra Medical Centre, WA, Australia 5 Communicable Disease Control Directorate, Western Australia Department of Health, WA, Australia 6 School of Pathology and Laboratory Medicine, University of Western Australia, WA, Australia 7 Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, WA, Australia 8 National Centre for Epidemiology and Population Health, Research School of Population Health, The Australian National University, ACT, Australia 9 Princess Margaret Hospital, WA, Australia 10 University of Western Australia School of Paediatrics and Child Health, Princess Margaret Hospital, WA, Australia 11 Department of General Medicine, Royal Children's Hospital, Victoria, Australia 12 SAEFVIC, Murdoch Childrens Research Institute, Victoria, Australia 13 Department of Paediatrics, The University of Melbourne, Victoria, Australia 14 Discipline of Paediatrics and Child Health, University of Sydney, NSW, Australia 15 Department of Microbiology and Infectious Diseases, The Children’s Hospital at Westmead, NSW, Australia 16 The members of the group are listed at the end of the article.Alexis Pillsburyalexis.pillsbury health.nsw.gov.au
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Citation style for this article: Pillsbury Alexis, Cashman Patrick, Leeb Alan, Regan Annette, Westphal Darren, Snelling Tom, Blyth Christopher, Crawford Nigel, Wood Nicholas, Macartney Kristine, on behalf of the AusVaxSafety . Real-time safety surveillance of seasonal influenza vaccines in children, Australia, 2015. Euro Surveill. 2015;20(43):pii=30050. https://doi.org/10.2807/1560-7917.ES.2015.20.43.30050 Received: 14 Oct 2015; Accepted: 29 Oct 2015
Abstract
Increased febrile reactions in Australian children from one influenza vaccine brand in 2010 diminished confidence in influenza immunisation, highlighting the need for improved vaccine safety surveillance. AusVaxSafety, a national vaccine safety surveillance system collected adverse events in young children for 2015 influenza vaccine brands in real time through parent/carer reports via SMS/email. Weekly cumulative data on 3,340 children demonstrated low rates of fever (4.4%) and medical attendance (1.1%). Fever was more frequent with concomitant vaccination.

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