Real-time safety surveillance of seasonal influenza vaccines in children, Australia, 2015

Alexis Pillsbury; Patrick Cashman; Alan Leeb; Annette Regan; Darren Westphal; Tom Snelling; Christopher Blyth; Nigel Crawford; Nicholas Wood; Kristine Macartney; on behalf of the AusVaxSafety

doi:10.2807/1560-7917.ES.2015.20.43.30050

Rapid communication Open Access

Like 0

Download

Real-time safety surveillance of seasonal influenza vaccines in children, Australia, 2015
Alexis Pillsbury¹ , Patrick Cashman^2,3 , Alan Leeb⁴ , Annette Regan^5,6 , Darren Westphal^5,7,8 , Tom Snelling^7,9 , Christopher Blyth^7,9,10 , Nigel Crawford^11,12,13 , Nicholas Wood^1,14 , Kristine Macartney^1,2,15 , on behalf of the AusVaxSafety ¹⁶
View Affiliations Hide Affiliations

Affiliations: ¹ National Centre for Immunisation Research and Surveillance, The Children’s Hospital at Westmead, NSW, Australia ² Hunter New England Local Health District, NSW, Australia ³ The University of Newcastle, NSW, Australia ⁴ Illawarra Medical Centre, WA, Australia ⁵ Communicable Disease Control Directorate, Western Australia Department of Health, WA, Australia ⁶ School of Pathology and Laboratory Medicine, University of Western Australia, WA, Australia ⁷ Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, WA, Australia ⁸ National Centre for Epidemiology and Population Health, Research School of Population Health, The Australian National University, ACT, Australia ⁹ Princess Margaret Hospital, WA, Australia ¹⁰ University of Western Australia School of Paediatrics and Child Health, Princess Margaret Hospital, WA, Australia ¹¹ Department of General Medicine, Royal Children's Hospital, Victoria, Australia ¹² SAEFVIC, Murdoch Childrens Research Institute, Victoria, Australia ¹³ Department of Paediatrics, The University of Melbourne, Victoria, Australia ¹⁴ Discipline of Paediatrics and Child Health, University of Sydney, NSW, Australia ¹⁵ Department of Microbiology and Infectious Diseases, The Children’s Hospital at Westmead, NSW, Australia ¹⁶ The members of the group are listed at the end of the article.

Correspondence:
Alexis Pillsbury
alexis.pillsbury health.nsw.gov.au
View Citation Hide Citation

Citation style for this article: Pillsbury Alexis, Cashman Patrick, Leeb Alan, Regan Annette, Westphal Darren, Snelling Tom, Blyth Christopher, Crawford Nigel, Wood Nicholas, Macartney Kristine, on behalf of the AusVaxSafety . Real-time safety surveillance of seasonal influenza vaccines in children, Australia, 2015. Euro Surveill. 2015;20(43):pii=30050. https://doi.org/10.2807/1560-7917.ES.2015.20.43.30050 Received: 14 Oct 2015; Accepted: 29 Oct 2015

Abstract

Increased febrile reactions in Australian children from one influenza vaccine brand in 2010 diminished confidence in influenza immunisation, highlighting the need for improved vaccine safety surveillance. AusVaxSafety, a national vaccine safety surveillance system collected adverse events in young children for 2015 influenza vaccine brands in real time through parent/carer reports via SMS/email. Weekly cumulative data on 3,340 children demonstrated low rates of fever (4.4%) and medical attendance (1.1%). Fever was more frequent with concomitant vaccination.

This work is licensed under a Creative Commons Attribution 4.0 International License.

Article metrics loading...

/content/10.2807/1560-7917.ES.2015.20.43.30050

2015-10-29

2025-05-01

Click here for cited by

/content/10.2807/1560-7917.ES.2015.20.43.30050

Full text loading...

/deliver/fulltext/eurosurveillance/20/43/eurosurv-20-30050-2.html?itemId=/content/10.2807/1560-7917.ES.2015.20.43.30050&mimeType=html&fmt=ahah

References

AusVaxSafety. AusVaxSafety Final report to the Australian Government Department of Health for Contract HEALTH/082/2014. Sydney: National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases; Dec 2014.
Khandaker G. Going national: AusVaxSafety 2014 and beyond. Active surveillance for adverse events following immunisation - new methods in vaccine pharmacovigilance. Conference on Vaccine safety: active surveillance for adverse events following immunisation – new methods in vaccine pharmacovigilance; 29 Oct 2014; North Sydney, Australia.
Hull B, Dey A, Beard F, Menzies R, Brotherton J, McIntyre P. Annual immunisation coverage report 2013. Westmead: National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases; 2013. Available from: http://ncirs.edu.au/assets/surveillance/coverage/2013-coverage-report-final.pdf
Australian demographic statistics, Mar 2015. Sydney: Australian Bureau of Statistics. [Accessed: 30 September 2015]. Available from: http://www.abs.gov.au/ausstats/[email protected]/mf/3101.0
Cashman P, Moberley S, Dalton C, Stephenson J, Elvidge E, Butler M, et al. Vaxtracker: Active on-line surveillance for adverse events following inactivated influenza vaccine in children. Vaccine. 2014;32(42):5503-8. https://doi.org/10.1016/j.vaccine.2014.07.061 PMID: 25077424
Leeb A, Regan AK, Peters IJ, Leeb C, Leeb G, Effler PV. Using automated text messages to monitor adverse events following immunisation in general practice. Med J Aust. 2014;200(7):416-8. https://doi.org/10.5694/mja13.11166 PMID: 24794676
Mahajan D, Dey A, Cook J, Harvey B, Menzies RI, Macartney KM. Surveillance of adverse events following immunisation in Australia, 2012. Commun Dis Intell Q Rep. 2014;38(3):E232-46. PMID: 25391415
Lucas J, Crosier R. Fast initial response for cusum quality-control schemes: give your cusum a head start. Technometrics. 1982;24(3):199-205. https://doi.org/10.1080/00401706.1982.10487759
Grigg OA, Farewell VT, Spiegelhalter DJ. Use of risk-adjusted CUSUM and RSPRT charts for monitoring in medical contexts. Stat Methods Med Res. 2003;12(2):147-70. PMID: 12665208
Blyth CC, Markus TY, Effler PV, Richmond PC. Ensuring safety of the 2011 trivalent influenza vaccine in young children. Med J Aust. 2011;195(1):52. PMID: 21728948
Wood NJ, Blyth CC, Willis GA, Richmond P, Gold MS, Buttery JP, et al. The safety of seasonal influenza vaccines in Australian children in 2013. Med J Aust. 2014;201(10):596-600. https://doi.org/10.5694/mja13.00097 PMID: 25390267
Li-Kim-Moy J, Yin JK, Rashid H, Khandaker G, King C, Wood N, et al. Systematic review of fever, febrile convulsions and serious adverse events following administration of inactivated trivalent influenza vaccines in children. Euro Surveill. 2015;20(24):21159. https://doi.org/10.2807/1560-7917.ES2015.20.24.21159 PMID: 26111238
Tracey LE, Regan AK, Mak DB, Effler PV. Adverse events following influenza immunization reported by healthcare personnel using active surveillance based on text messages. Infect Control Hosp Epidemiol. 2015;36(5):608-10. https://doi.org/10.1017/ice.2015.16 PMID: 25652211
Regan AK, Blyth CC, Mak DB, Richmond PC, Effler PV. Using SMS to monitor adverse events following trivalent influenza vaccination in pregnant women. Aust N Z J Obstet Gynaecol. 2014;54(6):522-8. https://doi.org/10.1111/ajo.12266 PMID: 25306915
Stockwell MS, Broder K, LaRussa P, Lewis P, Fernandez N, Sharma D, et al. Risk of fever after pediatric trivalent inactivated influenza vaccine and 13-valent pneumococcal conjugate vaccine. JAMA Pediatr. 2014;168(3):211-9. https://doi.org/10.1001/jamapediatrics.2013.4469 PMID: 24395025
Armstrong PK, Dowse GK, Effler PV, Carcione D, Blyth CC, Richmond PC, et al. Epidemiological study of severe febrile reactions in young children in Western Australia caused by a 2010 trivalent inactivated influenza vaccine. BMJ Open. 2011;1(1):e000016. https://doi.org/10.1136/bmjopen-2010-000016 PMID: 22021725
Rockman S, Dyson A, Koernig S, Becher D, Ng M, Morelli AB, et al. Evaluation of the bioactivity of influenza vaccine strains in vitro suggests that the introduction of new strains in the 2010 Southern Hemisphere trivalent influenza vaccine is associated with adverse events. Vaccine. 2014;32(30):3861-8. https://doi.org/10.1016/j.vaccine.2014.03.032 PMID: 24928062
Blyth CC, Richmond PC, Jacoby P, Thornton P, Regan A, Robins C, et al. The impact of pandemic A(H1N1)pdm09 influenza and vaccine-associated adverse events on parental attitudes and influenza vaccine uptake in young children. Vaccine. 2014;32(32):4075-81. https://doi.org/10.1016/j.vaccine.2014.05.055 PMID: 24877764
Government of Western Australia Department of Health. Child influenza vaccination rate low despite rise in uptake. Disease WAtch. 2013;17(4). Available from: http://www.health.wa.gov.au/diseasewatch/vol17_issue4/child_vaccination.cfm

Real-time safety surveillance of seasonal influenza vaccines in children, Australia, 2015

Citation style for this article: <a href="/search?value1=Alexis+Pillsbury&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pillsbury Alexis</a>, <a href="/search?value1=Patrick+Cashman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cashman Patrick</a>, <a href="/search?value1=Alan+Leeb&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Leeb Alan</a>, <a href="/search?value1=Annette+Regan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Regan Annette</a>, <a href="/search?value1=Darren+Westphal&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Westphal Darren</a>, <a href="/search?value1=Tom+Snelling&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Snelling Tom</a>, <a href="/search?value1=Christopher+Blyth&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Blyth Christopher</a>, <a href="/search?value1=Nigel+Crawford&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Crawford Nigel</a>, <a href="/search?value1=Nicholas+Wood&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wood Nicholas</a>, <a href="/search?value1=Kristine+Macartney&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Macartney Kristine</a>, <a href="/search?value1=on+behalf+of+the+AusVaxSafety&option1=author&noRedirect=true" class="nonDisambigAuthorLink">on behalf of the AusVaxSafety </a>. Real-time safety surveillance of seasonal influenza vaccines in children, Australia, 2015. <a href="/content/ecdc">Euro Surveill.</a> 2015;20(43):pii=30050. <a href="https://doi.org/10.2807/1560-7917.ES.2015.20.43.30050" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2015.20.43.30050</a> Received: 14 Oct 2015;   Accepted: 29 Oct 2015

/content/10.2807/1560-7917.ES.2015.20.43.30050

Data & Media loading...

Submit comment

Comment moderation successfully completed

Submit your article here

Submit an Article

Real-time safety surveillance of seasonal influenza vaccines in children, Australia, 2015

Abstract

Click here for cited by