- Sabine Vygen1,2,3, Aurélie Fischer1,3, Laure Meurice1, Ibrahim Mounchetrou Njoya4, Marina Gregoris5, Bakhao Ndiaye6, Adrien Ghenassia6, Isabelle Poujol7, Jean Paul Stahl8, Denise Antona9, Yann Le Strat10, Daniel Levy-Bruhl9,11, Patrick Rolland1,11
-
View Affiliations Hide AffiliationsAffiliations: 1 French Institute for Public Health Surveillance (InVS), Department of Coordination of Alerts and Regions (DCAR), Regional office in Aquitaine 2 European Program for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control (ECDC) 3 Both authors contributed equally as first authors 4 InVS, DCAR, Regional office Ile-de-France and Champagne-Ardenne, Chalons en Champagne, France 5 Regional health authority (ARS) Champagne-Ardennes 6 InVS, DCAR, Regional office North, France 7 InVS, DCAR, Regional office Rhône-Alpes, France 8 University hospital Grenoble, Hôpital A. Michallon, Boulevard de la Chantourne, La Tronche, France 9 InVS, Department of infectious diseases, Unit of respiratory and vaccine preventable diseases, France 10 InVS, Department of infectious diseases, France 11 Both authors contributed equally as last authorsSabine Vygenvygen-bonnets rki.de
-
View Citation Hide Citation
Citation style for this article: Vygen Sabine, Fischer Aurélie, Meurice Laure, Mounchetrou Njoya Ibrahim, Gregoris Marina, Ndiaye Bakhao, Ghenassia Adrien, Poujol Isabelle, Stahl Jean Paul, Antona Denise, Le Strat Yann, Levy-Bruhl Daniel, Rolland Patrick. Waning immunity against mumps in vaccinated young adults, France 2013. Euro Surveill. 2016;21(10):pii=30156. https://doi.org/10.2807/1560-7917.ES.2016.21.10.30156 Received: 21 Apr 2015; Accepted: 19 Oct 2015
Waning immunity against mumps in vaccinated young adults, France 2013
Abstract
In 2013, 15 clusters of mumps were notified in France; 72% (82/114) of the cases had been vaccinated twice with measles-mumps-rubella vaccine. To determine whether the risk of mumps increased with time since the last vaccination, we conducted a case–control study among clusters in universities and military barracks. A confirmed case had an inflammation of a salivary gland plus laboratory confirmation in 2013. A probable case presented with inflammation of a salivary gland in 2013 either lasting for > 2 days or with epidemiological link to a confirmed case. Controls had no mumps symptoms and attended the same university course, student party or military barracks. We collected clinical and vaccination data via web questionnaire and medical records. We calculated adjusted odds ratios (aOR) using logistic regression. 59% (50/85) of cases and 62% (199/321) of controls had been vaccinated twice. The odds of mumps increased for twice-vaccinated individuals by 10% for every year that had passed since the second dose (aOR 1.10; 95% confidence interval (CI): 1.02–1.19; p = 0.02). Mumps immunity waned with increasing time since vaccination. Our findings contributed to the French High Council of Public Health’s decision to recommend a third MMR dose during outbreaks for individuals whose second dose dates > 10 years.

Article metrics loading...

-
From This Site
/content/10.2807/1560-7917.ES.2016.21.10.30156dcterms_title,dcterms_subject,pub_keyword105 -
PubMed
-
Google Scholar

Full text loading...
References
-
Institut de Veille Sanitaire (InVS). Dossiers thématiques; Oreillons. [Thematic dossiers; mumps]. French. [Accessed 15 Jul 2013]. Available from: http://www.invs.sante.fr/Dossiers-thematiques/Maladies-infectieuses/Maladies-a-prevention-vaccinale/Oreillons
-
Coffinières E, Turbelin C, Riblier D, Aouba A, Levy-Bruhl D, Arena C, et al. Mumps: burden of disease in France. Vaccine. 2012;30(49):7013-8. https://doi.org/10.1016/j.vaccine.2012.09.070 PMID: 23059354
-
Nelson GE, Aguon A, Valencia E, Oliva R, Guerrero ML, Reyes R, et al. Epidemiology of a mumps outbreak in a highly vaccinated island population and use of a third dose of measles-mumps-rubella vaccine for outbreak control--Guam 2009 to 2010. Pediatr Infect Dis J. 2013;32(4):374-80. https://doi.org/10.1097/INF.0b013e318279f593 PMID: 23099425
-
Institut national de prévention et d'éducation pour la santé (Inpes), Paris, France. Vaccination contre les oreillons, dans Guide des vaccinations - Edition 2012, page 223-229. [Vaccination against mumps, in the guide to vaccinations – edition 2012, pp. 142-8]. Paris: Inpes; 2012. French. Available from: http://www.inpes.sante.fr/10000/themes/vaccination/guide-vaccination-2012/pdf/GuideVaccinations2012_Vaccination_contre_les_oreillons.pdf
-
Le calendrier des vaccinations et les recommandations vaccinales 1996-1997. [Vaccination calendar and vaccination recommendations 1996-1997]. Bull Epidemiol Hebd. 1996; 35: 151-3. French. Available from: http://www.invs.sante.fr/beh/1996/9635/index.html
-
Institut de Veille Sanitaire. Comité technique des vaccinations, Paris, France. Calendrier des vaccinations et les recommandations vaccinales 2013 selon l'avis du Haut conseil de la santé publique. [Vaccination calendar and vaccination recommendations for 2013 according to the opinion of the High council of public health]. Bull Epidemiol Hebd 2013;14-15. French. Available from: http://www.invs.sante.fr/Publications-et-outils/BEH-Bulletin-epidemiologique-hebdomadaire/Archives/2013/BEH-n-14-15-2013
-
Antona D, Fonteneau L, Lévy-Bruhl D, Guignon N, De Peretti C, Niel X, et al. Couverture vaccinale des enfants et des adolescents en France: résultats des enquêtes menées en milieu scolaire, 2001-2004. [Vaccination coverage of children and adolescents in France: results of a school survey, 2001-2014]. Bull Epidemiol Hebd 2007;6:45-9. French. Available from: http://www.invs.sante.fr/beh/2007/06/beh_06_2007.pdf
-
The French National Institute of Health and Medical Research (Inserm U707). University of Paris VI: Pierre and Marie Curie, Paris, France. Réseau Sentinelles [French GP sentinel network]. French. [Accessed in June 2013]. Available from: http://websenti.u707.jussieu.fr/sentiweb/?page=bilan
-
Sane J, Gouma S, Koopmans M, de Melker H, Swaan C, van Binnendijk R, et al. Epidemic of mumps among vaccinated persons, The Netherlands, 2009-2012. Emerg Infect Dis. 2014;20(4):643-8. https://doi.org/10.3201/eid2004.131681 PMID: 24655811
-
Dayan GH, Quinlisk MP, Parker AA, Barskey AE, Harris ML, Schwartz JM, et al. Recent resurgence of mumps in the United States. N Engl J Med. 2008;358(15):1580-9. https://doi.org/10.1056/NEJMoa0706589 PMID: 18403766
-
Eriksen J, Davidkin I, Kafatos G, Andrews N, Barbara C, Cohen D, et al. Seroepidemiology of mumps in Europe (1996-2008): why do outbreaks occur in highly vaccinated populations? Epidemiol Infect. 2013;141(3):651-66. https://doi.org/10.1017/S0950268812001136 PMID: 22687578
-
Anis E, Grotto I, Moerman L, Warshavsky B, Slater PE, Lev B. Mumps outbreak in Israel’s highly vaccinated society: are two doses enough? Epidemiol Infect. 2012;140(3):439-46. https://doi.org/10.1017/S095026881100063X PMID: 21554780
-
Dayan GH, Rubin S. Mumps outbreaks in vaccinated populations: are available mumps vaccines effective enough to prevent outbreaks? Clin Infect Dis. 2008;47(11):1458-67. https://doi.org/10.1086/591196 PMID: 18959494
-
Yung CF, Andrews N, Bukasa A, Brown KE, Ramsay M. Mumps complications and effects of mumps vaccination, England and Wales, 2002-2006. Emerg Infect Dis. 2011;17(4):661-7, quiz 766. https://doi.org/10.3201/eid1704.101461 PMID: 21470456
-
Cohen C, White JM, Savage EJ, Glynn JR, Choi Y, Andrews N, et al. Vaccine effectiveness estimates, 2004-2005 mumps outbreak, England. Emerg Infect Dis. 2007;13(1):12-7. https://doi.org/10.3201/eid1301.060649 PMID: 17370510
-
Marin M, Quinlisk P, Shimabukuro T, Sawhney C, Brown C, Lebaron CW. Mumps vaccination coverage and vaccine effectiveness in a large outbreak among college students--Iowa, 2006. Vaccine. 2008;26(29-30):3601-7. https://doi.org/10.1016/j.vaccine.2008.04.075 PMID: 18539365
-
Haut Conseil de la santé publique (HCSP). Avis relatif à la conduite à tenir en case d’épisodes de cas groupés d’oreillons en collectivité. Paris : HCSP; 11 Jul 2013. [Opinion on the conduct to adopt in the face of episodes of clusters of mumps in institutions]. French. Available from: http://www.hcsp.fr/Explore.cgi/avisrapportsdomaine?clefr=364
-
Gee S, O’Flanagan D, Fitzgerald M, Cotter S. Mumps in Ireland, 2004-2008. Euro Surveill. 2008;13(18):18857. Available from: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=18857 PMID: 18768133
-
Ogbuanu IU, Kutty PK, Hudson JM, Blog D, Abedi GR, Goodell S, et al. Impact of a third dose of measles-mumps-rubella vaccine on a mumps outbreak. Pediatrics. 2012 Dec;130(6):e1567-74. Available from: http://pediatrics.aappublications.org/content/130/6/e1567.full.pdf
-
Rajčević S, Šeguljev Z, Petrovic V, Medić S, Nedelijković J, Milosević V, et al. Ongoing mumps outbreak in Novi Sad, the autonomous province of Vojvodina, Serbia, January to April 2012. Euro Surveill. 2012;17(19):20169. PMID: 22607963
-
Quinlisk MP. Mumps control today. J Infect Dis. 2010;202(5):655-6. https://doi.org/10.1086/655395 PMID: 20662719
-
Cortese MM, Jordan HT, Curns AT, Quinlan PA, Ens KA, Denning PM, et al. Mumps vaccine performance among university students during a mumps outbreak. Clin Infect Dis. 2008;46(8):1172-80. https://doi.org/10.1086/529141 PMID: 18444852
-
Gouma S, Sane J, Gijselaar D, Cremer J, Hahné S, Koopmans M, et al. Two major mumps genotype G variants dominated recent mumps outbreaks in the Netherlands (2009-2012). J Gen Virol. 2014;95(Pt 5):1074-82. https://doi.org/10.1099/vir.0.062943-0 PMID: 24603524
-
Savage E, Ramsay M, White J, Beard S, Lawson H, Hunjan R, et al. Mumps outbreaks across England and Wales in 2004: observational study. BMJ. 2005;330(7500):1119-20. https://doi.org/10.1136/bmj.330.7500.1119 PMID: 15891227
-
Hahné S, Whelan J, van Binnendijk R, Swaan C, Fanoy E, Boot H, et al. Mumps vaccine effectiveness against orchitis. Emerg Infect Dis. 2012;18(1):191-3. https://doi.org/10.3201/eid1801.111178 PMID: 22260843
-
Ladbury G, Ostendorf S, Waegemaekers T, van Binnendijk R, Boot H, Hahné S. Smoking and older age associated with mumps in an outbreak in a group of highly-vaccinated individuals attending a youth club party, the Netherlands, 2012. Euro Surveill. 2014;19(16):20776. . Available from: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20776 https://doi.org/10.2807/1560-7917.ES2014.19.16.20776 PMID: 24786261
-
De Serres G, Boulianne N, Defay F, Brousseau N, Benoît M, Lacoursière S, et al. Higher risk of measles when the first dose of a 2-dose schedule is given at 12-14 versus 15 months of age. Clin Infect Dis. 2012;55(3):394-402. https://doi.org/10.1093/cid/cis439 PMID: 22543023
-
Hall R, Richards H. Hearing loss due to mumps. Arch Dis Child. 1987;62(2):189-91. https://doi.org/10.1136/adc.62.2.189 PMID: 3827297
-
Gupta RK, Best J, MacMahon E. Mumps and the UK epidemic 2005. BMJ. 2005;330(7500):1132-5. . Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC557899/ https://doi.org/10.1136/bmj.330.7500.1132 PMID: 15891229
-
Arday DR, Kanjarpane DD, Kelley PW. Mumps in the US Army 1980-86: should recruits be immunized? Am J Public Health. 1989;79(4):471-4. https://doi.org/10.2105/AJPH.79.4.471 PMID: 2494895
-
Rubin SA, Plotkin SA. Mumps vaccine. In: Plotkin S, Orenstein W, Offit P, editors. Vaccines. 6th ed. Philadelphia: Saunders; 2012. p. 419-46.
-
Levine H, Rishpon S, Huerta-Hartal M, Davidovitch N. Preventing mumps outbreaks in confined settings: comprehensive ring vaccination as a containment strategy. Hum Vaccin. 2011;7(12):1389-93. . Available from: http://www.tandfonline.com/doi/abs/10.4161/hv.7.12.18111 https://doi.org/10.4161/hv.7.12.18111 PMID: 22108037
-
Gouma S, Schurink-Van’t Klooster TM, de Melker HE, Kerkhof J, Smits GP, Hahné SJ, et al. Mumps serum antibody levels before and after an outbreak to assess infection and immunity in vaccinated students. Open Forum Infect Dis. 2014;1(3):ofu101. https://doi.org/10.1093/ofid/ofu101 PMID: 25734169

Data & Media loading...
