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Abstract

On 6 September 2014, the accidental release of 1013 infectious wild poliovirus type 3 (WPV3) particles by a vaccine production plant in Belgium was reported. WPV3 was released into the sewage system and discharged directly to a wastewater treatment plant (WWTP) and subsequently into rivers that flowed to the Western Scheldt and the North Sea. No poliovirus was detected in samples from the WWTP, surface waters, mussels or sewage from the Netherlands. Quantitative microbial risk assessment (QMRA) showed that the infection risks resulting from swimming in Belgium waters were above 50% for several days and that the infection risk by consuming shellfish harvested in the eastern part of the Western Scheldt warranted a shellfish cooking advice. We conclude that the reported release of WPV3 has neither resulted in detectable levels of poliovirus in any of the samples nor in poliovirus circulation in the Netherlands. This QMRA showed that relevant data on water flows were not readily available and that prior assumptions on dilution factors were overestimated. A QMRA should have been performed by all vaccine production facilities before starting up large-scale culture of WPV to be able to implement effective interventions when an accident happens.

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/content/10.2807/1560-7917.ES.2016.21.11.30169
2016-03-17
2024-03-29
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.11.30169
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References

  1. European Centre for Disease Prevention and Control (ECDC). The accidental release of 45 litres of concentrated live polio virus solution into the environment – Belgium. In: Monitoring current threats: ECDC Communicable Disease Threats Report (CDTR), week 37/2014. Stockholm: ECDC; 2014. Available from: http://ecdc.europa.eu/en/press/news/_layouts/forms/News_DispForm.aspx?List=8db7286c-fe2d-476c-9133-18ff4cb1b568&ID=1065
  2. Shulman LM, Gavrilin E, Jorba J, Martin J, Burns CC, Manor Y, et al. Molecular epidemiology of silent introduction and sustained transmission of wild poliovirus type 1, Israel, 2013. Euro Surveill. 2014;19(7):20709. https://doi.org/10.2807/1560-7917.ES2014.19.7.20709  PMID: 24576471 
  3. Bertrand I, Schijven JF, Sánchez G, Wyn-Jones P, Ottoson J, Morin T, et al. The impact of temperature on the inactivation of enteric viruses in food and water: a review. J Appl Microbiol. 2012;112(6):1059-74. https://doi.org/10.1111/j.1365-2672.2012.05267.x  PMID: 22380614 
  4. Greening G. Human and animal viruses in food. In: Viruses in foods. Ed. Goyal. Springer 2006.
  5. McLeod C, Hay B, Grant C, Greening G, Day D. Localization of norovirus and poliovirus in Pacific oysters. J Appl Microbiol. 2009;106(4):1220-30. https://doi.org/10.1111/j.1365-2672.2008.04091.x  PMID: 19187161 
  6. World Health Organization (WHO). GAPIII. WHO global action plan to minimize poliovirus facility-associated risk after type-specific eradication of wild polioviruses and sequential cessation of OPV use. Geneva: WHO; 2015. Available from: http://www.polioeradication.org/Portals/0/Document/Resources/PostEradication/GAPIII_2015.pdf
  7. Khetsuriani N, Pfeifer D, Deshevoi S, Gavrilin E, Shefer A, Butler R, et al. Challenges of maintaining polio-free status of the European Region. J Infect Dis. 2014;210(Suppl 1):S194-207. https://doi.org/10.1093/infdis/jiu096  PMID: 25316836 
  8. Lodder WJ, de Roda Husman AM. Presence of noroviruses and other enteric viruses in sewage and surface waters in The Netherlands. Appl Environ Microbiol. 2005;71(3):1453-61. https://doi.org/10.1128/AEM.71.3.1453-1461.2005  PMID: 15746348 
  9. Dowdle WR, Birmingham ME. The biologic principles of poliovirus eradication. J Infect Dis. 1997;175(Suppl 1):S286-92. https://doi.org/10.1093/infdis/175.Supplement_1.S286  PMID: 9203732 
  10. Schijven JF, Teunis PF, Rutjes SA, Bouwknegt M, de Roda Husman AM. QMRAspot: a tool for Quantitative Microbial Risk Assessment from surface water to potable water. Water Res. 2011;45(17):5564-76. https://doi.org/10.1016/j.watres.2011.08.024  PMID: 21885080 
  11. Lodder WJ, Schijven JF, Rutjes SA, de Roda Husman AM, Teunis PF. Entero- and parechovirus distributions in surface water and probabilities of exposure to these viruses during water recreation. Water Res. 2015;75:25-32. https://doi.org/10.1016/j.watres.2015.02.024  PMID: 25746959 
  12. Schets FM, Schijven JF, de Roda Husman AM. Exposure assessment for swimmers in bathing waters and swimming pools. Water Res. 2011;45(7):2392-400. https://doi.org/10.1016/j.watres.2011.01.025  PMID: 21371734 
  13. Bouwknegt M, Verhaelen K, de Roda Husman AM, Rutjes SA. Quantitative risk profile for viruses in foods. Report 330371008. Bilthoven: National Institute for Public Health and the Environment (RIVM); 2013. Available from: http://www.rivm.nl/en/Documents_and_publications/Scientific/Reports/2013/mei/Quantitative_risk_profile_for_viruses_in_foods
  14. Teunis PFM, Havelaar AH. The dose-response relation in human volunteers for gastro-intestinal pathogens. Report 284550002. Bilthoven: National Institute for Public Health and the Environment (RIVM); 1996. Available from: http://www.rivm.nl/en/Documents_and_publications/Scientific/Reports/1996/april/The_dose_response_relation_in_human_volunteers_for_gastro_intestinal_pathogens?sp=cml2bXE9ZmFsc2U7c2VhcmNoYmFzZT02NDc5MDtyaXZtcT1mYWxzZTs=&pagenr=6480
  15. DKTP vaccinaties, verslagjaar 2014. [DPTP vaccinations, reporting year 2014]. Bilthoven: National Institute for Public Health and the Environment (RIVM); 2014. Dutch. Available from: http://www.zorgatlas.nl/preventie/vaccinaties-en-screening/dktp-per-gemeente/#breadcrumb
  16. Skraber S, Schijven J, Italiaander R, de Roda Husman AM. Accumulation of enteric bacteriophage in fresh water sediments. J Water Health. 2009;7(3):372-9. https://doi.org/10.2166/wh.2009.098  PMID: 19491489 
  17. Microbiology of food and animal feed -- Horizontal method for determination of hepatitis A virus and norovirus in food using real-time RT-PCR; ISO/TS 15216. Geneva: ISO; 2013. Available from: http://www.iso.org/iso/home/store/catalogue_ics/catalogue_detail_ics.htm?csnumber=55382
  18. Pipkin PA, Wood DJ, Racaniello VR, Minor PD. Characterisation of L cells expressing the human poliovirus receptor for the specific detection of polioviruses in vitro. J Virol Methods. 1993;41(3):333-40. https://doi.org/10.1016/0166-0934(93)90022-J  PMID: 8386181 
  19. Wecker I, ter Meulen V. RD cells in the laboratory diagnosis of enteroviruses. Med Microbiol Immunol. 1977;163(4):233-40. https://doi.org/10.1007/BF02125507  PMID: 203835 
  20. Duizer E, Benschop K, Uslu G, Jusic E, Schalk M, Koen G, et al. Verleden, heden en toekomst van de enterovirus en parechovirus diagnostiek en surveillance in Nederland. Ned Tijdschr Med Microbiol.2013;21(2):50-5.
  21. van der Sanden S, de Bruin E, Vennema H, Swanink C, Koopmans M, van der Avoort H. Prevalence of human parechovirus in the Netherlands in 2000 to 2007. J Clin Microbiol. 2008;46(9):2884-9. https://doi.org/10.1128/JCM.00168-08  PMID: 18614653 
  22. Nix WA, Oberste MS, Pallansch MA. Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens. J Clin Microbiol. 2006;44(8):2698-704. https://doi.org/10.1128/JCM.00542-06  PMID: 16891480 
  23. Nijst OE, Mouthaan JJ, Mekkes DR, Jusic E, van der Avoort HG, Metz B. Rapid and accurate identification of poliovirus strains used for vaccine production. J Virol Methods. 2013;189(1):189-95. https://doi.org/10.1016/j.jviromet.2013.01.026  PMID: 23434540 
  24. Schijven JF, Hassanizadeh SM. Removal of viruses by soil passage: Overview of modeling, processes, and parameters. Crit Rev Environ Sci Technol. 2000;30(1):49-127.  https://doi.org/10.1080/10643380091184174 
  25. Schijven JF, de Bruin HA, Hassanizadeh SM, de Roda Husman AM. Bacteriophages and Clostridium spores as indicator organisms for removal of pathogens by passage through saturated dune sand. Water Res. 2003;37(9):2186-94. https://doi.org/10.1016/S0043-1354(02)00627-9  PMID: 12691904 
  26. Thomassen YE, van Eikenhorst G, van der Pol LA, Bakker WA. Isoelectric point determination of live polioviruses by capillary isoelectric focusing with whole column imaging detection. Anal Chem. 2013;85(12):6089-94. https://doi.org/10.1021/ac400968q  PMID: 23672432 
  27. Simmons FJ, Kuo DH, Xagoraraki I. Removal of human enteric viruses by a full-scale membrane bioreactor during municipal wastewater processing. Water Res. 2011;45(9):2739-50. https://doi.org/10.1016/j.watres.2011.02.001  PMID: 21453953 
  28. Lodder WJ, Buisman AM, Rutjes SA, Heijne JC, Teunis PF, de Roda Husman AM. Feasibility of quantitative environmental surveillance in poliovirus eradication strategies. Appl Environ Microbiol. 2012;78(11):3800-5. https://doi.org/10.1128/AEM.07972-11  PMID: 22447593 
  29. Duintjer Tebbens RJ, Pallansch MA, Chumakov KM, Halsey NA, Hovi T, Minor PD, et al. Review and assessment of poliovirus immunity and transmission: synthesis of knowledge gaps and identification of research needs. Risk Anal. 2013;33(4):606-46. https://doi.org/10.1111/risa.12031  PMID: 23550968 
  30. Convention on the protection and use of transboundary watercourses and international lakes done at Helsinki, on 17 March 1992. Luxembourg: Official Journal of the European Communities; 1992. Available from: http://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:21995A0805(01)&from=EN
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