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Abstract

In 2015/16, the influenza season in the United Kingdom was dominated by influenza A(H1N1)pdm09 circulation. Virus characterisation indicated the emergence of genetic clusters, with the majority antigenically similar to the current influenza A(H1N1)pdm09 vaccine strain. Mid-season vaccine effectiveness (VE) estimates show an adjusted VE of 41.5% (95% confidence interval (CI): 3.0–64.7) against influenza-confirmed primary care consultations and of 49.1% (95% CI: 9.3–71.5) against influenza A(H1N1)pdm09. These estimates show levels of protection similar to the 2010/11 season, when this strain was first used in the seasonal vaccine.

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/content/10.2807/1560-7917.ES.2016.21.13.30179
2016-03-31
2019-12-10
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.13.30179
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References

  1. Hakin B, Cosford P, Harvey F. The flu immunisation programme 2013/14– extension to children. London: Department of Health; 26 Jul 2013. Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/225360/Children_s_flu_letter_2013.pdf
  2. Public Health England (PHE). PHE weekly national influenza report. Summary of UK surveillance of influenza and other seasonal respiratory illnesses 17 March 2016 – Week 11 report (up to week 10 data). London: PHE; 17 Mar 2016. Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/508660/Weekly_report_current_wk_11_17Mar2016.pdf
  3. Fleming DM, Andrews NJ, Ellis JS, Bermingham A, Sebastianpillai P, Elliot AJ, et al. Estimating influenza vaccine effectiveness using routinely collected laboratory data. J Epidemiol Community Health. 2010;64(12):1062-7.  https://doi.org/10.1136/jech.2009.093450  PMID: 19910645 
  4. Andrews N, McMenamin J, Durnall H, Ellis J, Lackenby A, Robertson C, et al. Effectiveness of trivalent seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2012/13 end of season results. Euro Surveill. 2014;19(27): 20851.  https://doi.org/10.2807/1560-7917.ES2014.19.27.20851  PMID: 25033051 
  5. Ellis J, Iturriza M, Allen R, Bermingham A, Brown K, Gray J, et al. Evaluation of four real-time PCR assays for detection of influenza A(H1N1)v viruses. Euro Surveill. 2009;14(22):19230. PMID: 19497254 
  6. Gunson R, Maclean A, Davies E, Bennett S, Miller R, Carman WF. Development of a multiplex real-time RT-PCR that allows universal detection of influenza A viruses and simultaneous typing of influenza A/H1N1/2009 virus. J Virol Methods. 2010;163(2):258-61.  https://doi.org/10.1016/j.jviromet.2009.10.006  PMID: 19854220 
  7. Galiano M, Agapow P-M, Thompson C, Platt S, Underwood A, Ellis J, et al. Evolutionary pathways of the pandemic influenza A (H1N1) 2009 in the UK. PLoS One. 2011;6(8):e23779.  https://doi.org/10.1371/journal.pone.0023779  PMID: 21887318 
  8. Matrosovich M, Matrosovich T, Carr J, Roberts NA, Klenk HD. Overexpression of the alpha-2,6-sialyltransferase in MDCK cells increases influenza virus sensitivity to neuraminidase inhibitors. J Virol. 2003;77(15):8418-25.  https://doi.org/10.1128/JVI.77.15.8418-8425.2003  PMID: 12857911 
  9. Zambon M. Laboratory Diagnosis of Influenza. In: Nicholson K, Hay A, Webster RG, editors. Textbook of Influenza. Oxford: Blackwell Science; 1998. pp. 291-313.
  10. Tamura K, Stecher G, Peterson D, Filipski A, Kumar S. MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Mol Biol Evol. 2013;30(12):2725-9.  https://doi.org/10.1093/molbev/mst197  PMID: 24132122 
  11. European Centre for Disease Prevention and Control (ECDC). Seasonal influenza 2015–16 in the EU/EEA countries. Stockholm: ECDC; 2016. Available from: http://ecdc.europa.eu/en/publications/Publications/seasonal-influenza-risk-assessment-2015-2016.pdf
  12. Pebody R, Hardelid P, Fleming D, McMenamin J, Andrews N, Robertson C, et al. Effectiveness of seasonal 2010/11 and pandemic influenza A(H1N1)2009 vaccines in preventing influenza infection in the United Kingdom: mid-season analysis 2010/11. Euro Surveill. 2011;16(6):19791. PMID: 21329644 
  13. Kissling E, Valenciano M. Early influenza vaccine effectiveness results 2015-16: I-MOVE multicentre case-control study. Euro Surveill. 2016;21(6):30134.  https://doi.org/10.2807/1560-7917.ES.2016.21.6.30134  PMID: 26898240 
  14. Chambers C, Skowronski D, Sabaiduc S, Winter A, Dickinson J, De Serres G, et al. Interim estimates of 2015/16 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, February 2016. Euro Surveill. 2016;21(11):30168.  https://doi.org/10.2807/1560-7917.ES.2016.21.11.30168 
  15. World Health Organization (WHO). Recommended composition of influenza virus vaccines for use in the 2016-17 northern hemisphere influenza season. Geneva: WHO; 25 February 2016. Available from: http://www.who.int/influenza/vaccines/virus/recommendations/2016_17_north/en/
Effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2015/16 mid-season results
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Richard+Pebody&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pebody Richard</a>, <a href="/search?value1=Fiona+Warburton&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Warburton Fiona</a>, <a href="/search?value1=Joanna+Ellis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ellis Joanna</a>, <a href="/search?value1=Nick+Andrews&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Andrews Nick</a>, <a href="/search?value1=Alison+Potts&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Potts Alison</a>, <a href="/search?value1=Simon+Cottrell&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cottrell Simon</a>, <a href="/search?value1=Jillian+Johnston&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Johnston Jillian</a>, <a href="/search?value1=Arlene+Reynolds&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Reynolds Arlene</a>, <a href="/search?value1=Rory+Gunson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gunson Rory</a>, <a href="/search?value1=Catherine+Thompson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Thompson Catherine</a>, <a href="/search?value1=Monica+Galiano&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Galiano Monica</a>, <a href="/search?value1=Chris+Robertson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Robertson Chris</a>, <a href="/search?value1=David+Mullett&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mullett David</a>, <a href="/search?value1=Naomh+Gallagher&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gallagher Naomh</a>, <a href="/search?value1=Mary+Sinnathamby&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sinnathamby Mary</a>, <a href="/search?value1=Ivelina+Yonova&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yonova Ivelina</a>, <a href="/search?value1=Catherine+Moore&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Moore Catherine</a>, <a href="/search?value1=Jim+McMenamin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">McMenamin Jim</a>, <a href="/search?value1=Simon+de+Lusignan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">de Lusignan Simon</a>, <a href="/search?value1=Maria+Zambon&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zambon Maria</a></span>. Effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2015/16 mid-season results. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(13):pii=30179. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.13.30179" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.13.30179</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 26 Feb 2016;&nbsp;&nbsp; <span class="generated">Accepted</span>: 30 Mar 2016 </span> </p>
/content/10.2807/1560-7917.ES.2016.21.13.30179
/content/10.2807/1560-7917.ES.2016.21.13.30179
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