- Marcela Mercado1, Jorge Acosta-Reyes2, Edgar Parra3, Lissethe Pardo3, Angélica Rico3, Alfonso Campo4, Edgar Navarro2, Diego Viasus5
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View Affiliations Hide AffiliationsAffiliations: 1 Division of Research in Public Health, National Institute of Health of Colombia, Bogota, Colombia 2 Faculty of Public Health, Division of Health Sciences, Universidad del Norte and Hospital Universidad del Norte, Barranquilla, Colombia 3 Direction of Public Health Networks, Virology and Pathology Laboratories, National Institute of Health of Colombia, Bogotá, Colombia 4 Division of Surveillance in Public Health, National Institute of Health of Colombia, Bogota, Colombia 5 Faculty of Medicine, Division of Health Sciences, Universidad del Norte and Hospital Universidad del Norte, Barranquilla, ColombiaDiego Viasusdviasus uninorte.edu.co
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Citation style for this article: Mercado Marcela, Acosta-Reyes Jorge, Parra Edgar, Pardo Lissethe, Rico Angélica, Campo Alfonso, Navarro Edgar, Viasus Diego. Clinical and histopathological features of fatal cases with dengue and chikungunya virus co-infection in Colombia, 2014 to 2015. Euro Surveill. 2016;21(22):pii=30244. https://doi.org/10.2807/1560-7917.ES.2016.21.22.30244 Received: 28 Oct 2015; Accepted: 17 Mar 2016
Clinical and histopathological features of fatal cases with dengue and chikungunya virus co-infection in Colombia, 2014 to 2015
Abstract
We report clinical features and histopathological findings in fatal cases with dengue (DENV) and chikungunya (CHIKV) co-infection identified at the Colombian National Institute of Health between September 2014 and October 2015. Seven such cases were documented. Dengue serotype 2 virus was identified in six cases. All patients were adults and comorbidities were present in four. Fever, arthralgia or myalgia was present in all cases. The frequency of rash, haemorrhage, oedema, and gastrointestinal symptoms was variable. Laboratory findings such as thrombocytopenia, renal failure, and leukocyte count were also inconsistent between cases. Post-mortem tissue examination documented focal hepatocellular coagulative necrosis in three cases, incipient acute pericarditis in one and tubulointerstitial nephritis in one. This study provides evidence of mortality in patients with DENV and CHIKV co-infection. Fatal cases were characterised by variable clinical and laboratory features. Evaluation of histopathology of autopsy tissues provided evidence of the pathological consequences of the disease.

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