1887
  1. Home
  2. Eurosurveillance
  3. Volume 21, Issue 26, 30/Jun/2016
  4. Article
Rapid communication Open Access
Like 0
Download

Abstract

Zika virus RNA presence in serum, whole-blood and urine samples from six Israeli travellers symptomatic for Zika virus disease was examined. Whole-blood samples were positive for as late as 2 months (58 days) post-symptom onset, longer than for urine (26 days) and serum (3 days). These findings suggest the utility of whole blood in Zika infection diagnosis.

© Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2016.21.26.30269
2016-06-30
2025-06-23
/content/10.2807/1560-7917.ES.2016.21.26.30269
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/21/26/eurosurv-21-30269-2.html?itemId=/content/10.2807/1560-7917.ES.2016.21.26.30269&mimeType=html&fmt=ahah

References

  1. World Health Organization (WHO). WHO Director-General summarizes the outcome of the Emergency Committee regarding clusters of microcephaly and Guillain-Barré syndrome. Geneva: WHO; 1 Feb 2016. Available from: http://www.who.int/mediacentre/news/statements/2016/emergency-committee-zika-microcephaly/en/
  2. Gourinat AC, O’Connor O, Calvez E, Goarant C, Dupont-Rouzeyrol M. Detection of Zika virus in urine. Emerg Infect Dis. 2015;21(1):84-6.  https://doi.org/10.3201/eid2101.140894  PMID: 25530324 
  3. Musso D, Roche C, Nhan TX, Robin E, Teissier A, Cao-Lormeau VM. Detection of Zika virus in saliva. J Clin Virol. 2015;68:53-5.  https://doi.org/10.1016/j.jcv.2015.04.021  PMID: 26071336 
  4. Bingham AM, Cone M, Mock V, Heberlein-Larson L, Stanek D, Blackmore C, et al. Comparison of Test Results for Zika Virus RNA in Urine, Serum, and Saliva Specimens from Persons with Travel-Associated Zika Virus Disease - Florida, 2016. MMWR Morb Mortal Wkly Rep. 2016;65(18):475-8.  https://doi.org/10.15585/mmwr.mm6518e2  PMID: 27171533 
  5. Meltzer E, Leshem E, Lustig Y, Gottesman G, Schwartz E. The clinical spectrum of Zika virus in returning travelers. Am J Med. 2016;S0002-9343(16)30536-8. PMID: 27260832 
  6. Meltzer E, Lustig Y, Leshem E, Levy R, Gottesman G, Weissmann R, et al. Zika Virus Disease in Traveler Returning from Vietnam to Israel. Emerg Infect Dis. 2016;22(8).  https://doi.org/10.3201/eid2208.160480  PMID: 27331627 
  7. Shulman LM, Hindiyeh M, Muhsen K, Cohen D, Mendelson E, Sofer D. Evaluation of four different systems for extraction of RNA from stool suspensions using MS-2 coliphage as an exogenous control for RT-PCR inhibition. PLoS One. 2012;7(7):e39455.  https://doi.org/10.1371/journal.pone.0039455  PMID: 22815706 
  8. Lanciotti RS, Kosoy OL, Laven JJ, Velez JO, Lambert AJ, Johnson AJ, et al. Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis. 2008;14(8):1232-9.  https://doi.org/10.3201/eid1408.080287  PMID: 18680646 
  9. Huzly D, Hanselmann I, Schmidt-Chanasit J, Panning M. High specificity of a novel Zika virus ELISA in European patients after exposure to different flaviviruses. Euro Surveill. 2016;21(16):30203.  https://doi.org/10.2807/1560-7917.ES.2016.21.16.30203  PMID: 27126052 
  10. Fauci AS, Morens DM. Zika Virus in the Americas--Yet Another Arbovirus Threat. N Engl J Med. 2016;374(7):601-4.  https://doi.org/10.1056/NEJMp1600297  PMID: 26761185 
  11. Lai L, Lee TH, Tobler L, Wen L, Shi P, Alexander J, et al. Relative distribution of West Nile virus RNA in blood compartments: implications for blood donor nucleic acid amplification technology screening. Transfusion. 2012;52(2):447-54.  https://doi.org/10.1111/j.1537-2995.2011.03289.x  PMID: 21827506 
  12. Lanteri MC, Lee TH, Wen L, Kaidarova Z, Bravo MD, Kiely NE, et al. West Nile virus nucleic acid persistence in whole blood months after clearance in plasma: implication for transfusion and transplantation safety. Transfusion. 2014;54(12):3232-41.  https://doi.org/10.1111/trf.12764  PMID: 24965017 
  13. Rios M, Daniel S, Chancey C, Hewlett IK, Stramer SL. West Nile virus adheres to human red blood cells in whole blood. Clin Infect Dis. 2007;45(2):181-6.  https://doi.org/10.1086/518850  PMID: 17578776 
  14. Lustig Y, Mannasse B, Koren R, Katz-Likvornik S, Hindiyeh M, Mandelboim M, et al. Superiority of West Nile Virus RNA detection in whole blood for diagnosis of acute infection. J Clin Microbiol. 2016;JCM.01283-16.  https://doi.org/10.1128/JCM.01283-16  PMID: 27335150 
  15. Klungthong C, Gibbons RV, Thaisomboonsuk B, Nisalak A, Kalayanarooj S, Thirawuth V, et al. Dengue virus detection using whole blood for reverse transcriptase PCR and virus isolation. J Clin Microbiol. 2007;45(8):2480-5.  https://doi.org/10.1128/JCM.00305-07  PMID: 17522268 
  16. Frank C, Cadar D, Schlaphof A, Neddersen N, Günther S, Schmidt-Chanasit J, et al. Sexual transmission of Zika virus in Germany, April 2016. Euro Surveill. 2016;21(23):30252.  https://doi.org/10.2807/1560-7917.ES.2016.21.23.30252  PMID: 27311329 
  17. Musso D, Roche C, Robin E, Nhan T, Teissier A, Cao-Lormeau VM. Potential sexual transmission of Zika virus. Emerg Infect Dis. 2015;21(2):359-61.  https://doi.org/10.3201/eid2102.141363  PMID: 25625872 
  18. Reusken C, Pas S, GeurtsvanKessel C, Mögling R, van Kampen J, Langerak T, et al. Longitudinal follow-up of Zika virus RNA in semen of a traveller returning from Barbados to the Netherlands with Zika virus disease, March 2016. Euro Surveill. 2016;21(23):30251.  https://doi.org/10.2807/1560-7917.ES.2016.21.23.30251  PMID: 27313200 
Detection of Zika virus RNA in whole blood of imported Zika virus disease cases up to 2 months after symptom onset, Israel, December 2015 to April 2016
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Yaniv+Lustig&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lustig Yaniv</a>, <a href="/search?value1=Ella+Mendelson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mendelson Ella</a>, <a href="/search?value1=Nir+Paran&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Paran Nir</a>, <a href="/search?value1=Sharon+Melamed&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Melamed Sharon</a>, <a href="/search?value1=Eli+Schwartz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schwartz Eli</a></span>. Detection of Zika virus RNA in whole blood of imported Zika virus disease cases up to 2 months after symptom onset, Israel, December 2015 to April 2016. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(26):pii=30269. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.26.30269" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.26.30269</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 15 Jun 2016;&nbsp;&nbsp; <span class="generated">Accepted</span>: 30 Jun 2016 </span> </p>
/content/10.2807/1560-7917.ES.2016.21.26.30269
/content/10.2807/1560-7917.ES.2016.21.26.30269
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error