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Abstract

In 2006, Belgium was the first country in the European Union to recommend rotavirus vaccination in the routine infant vaccination schedule and rapidly achieved high vaccine uptake (86–89% in 2007). We used regional and national data sources up to 7 years post-vaccination to study the impact of vaccination on laboratory-confirmed rotavirus cases and rotavirus-related hospitalisations and deaths. We showed that (i) from 2007 until 2013, vaccination coverage remained at 79–88% for a complete course, (ii) in children 0–2 years, rotavirus cases decreased by 79% (95% confidence intervals (CI): 68–­89%) in 2008–2014 compared to the pre-vaccination period (1999–­2006) and by 50% (95% CI: 14–82%) in the age group ≥ 10 years, (iii) hospitalisations for rotavirus gastroenteritis decreased by 87% (95% CI: 84–90%) in 2008–­2012 compared to the pre-vaccination period (2002–­2006), (iv) median age of rotavirus cases increased from 12 months to 17 months and (v) the rotavirus seasonal peak was reduced and delayed in all post-vaccination years. The substantial decline in rotavirus gastroenteritis requiring hospitalisations and in rotavirus activity following introduction of rotavirus vaccination is sustained over time and more pronounced in the target age group, but with evidence of herd immunity.

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/content/10.2807/1560-7917.ES.2016.21.27.30273
2016-07-07
2024-09-18
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.27.30273
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Sustained low rotavirus activity and hospitalisation rates in the post-vaccination era in Belgium, 2007 to 2014
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Martine+Sabbe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sabbe Martine</a>, <a href="/search?value1=Nicolas+Berger&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Berger Nicolas</a>, <a href="/search?value1=Adriaan+Blommaert&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Blommaert Adriaan</a>, <a href="/search?value1=Benson+Ogunjimi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ogunjimi Benson</a>, <a href="/search?value1=Tine+Grammens&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Grammens Tine</a>, <a href="/search?value1=Michiel+Callens&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Callens Michiel</a>, <a href="/search?value1=Koen+Van+Herck&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Van Herck Koen</a>, <a href="/search?value1=Philippe+Beutels&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Beutels Philippe</a>, <a href="/search?value1=Pierre+Van+Damme&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Van Damme Pierre</a>, <a href="/search?value1=Joke+Bilcke&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bilcke Joke</a></span>. Sustained low rotavirus activity and hospitalisation rates in the post-vaccination era in Belgium, 2007 to 2014. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(27):pii=30273. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.27.30273" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.27.30273</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 19 May 2015;&nbsp;&nbsp; <span class="generated">Accepted</span>: 02 Oct 2015 </span> </p>
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