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Abstract

In 2014, 18 hospitals in the Czech Republic participated in a survey of the incidence of infections (CDI) in the country. The mean CDI incidence was 6.1 (standard deviation (SD):7.2) cases per 10,000 patient bed-days and 37.8 cases (SD: 41.4) per 10,000 admissions. The mean CDI testing frequency was 39.5 tests (SD: 25.4) per 10,000 patient bed-days and 255.8 tests (SD: 164.0) per 10,000 admissions. A total of 774 isolates were investigated, of which 225 (29%) belonged to PCR ribotype 176, and 184 isolates (24%) belonged to PCR ribotype 001. Multilocus variable-number tandem repeat analysis (MLVA) revealed 27 clonal complexes formed by 84% (190/225) of PCR ribotype 176 isolates, and 14 clonal complexes formed by 77% (141/184) of PCR ribotype 001 isolates. Clonal clusters of PCR ribotypes 176 and 001 were observed in 11 and 7 hospitals, respectively. Our data demonstrate the spread of two PCR ribotypes within 18 hospitals in the Czech Republic, stressing the importance of standardising CDI testing protocols and implementing mandatory CDI surveillance in the country.

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2016-07-21
2025-07-09
/content/10.2807/1560-7917.ES.2016.21.29.30296
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Clostridium difficile PCR ribotypes 001 and 176 – the common denominator of C. difficile infection epidemiology in the Czech Republic, 2014
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Marcela+Krutova&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Krutova Marcela</a>, <a href="/search?value1=Jana+Matejkova&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Matejkova Jana</a>, <a href="/search?value1=Ed+J+Kuijper&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kuijper Ed J</a>, <a href="/search?value1=Pavel+Drevinek&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Drevinek Pavel</a>, <a href="/search?value1=Otakar+Nyc&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nyc Otakar</a>, <a href="/search?value1=Czech+Clostridium+difficile+study+group&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Czech Clostridium difficile study group</a></span>. Clostridium difficile PCR ribotypes 001 and 176 – the common denominator of C. difficile infection epidemiology in the Czech Republic, 2014. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(29):pii=30296. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.29.30296" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.29.30296</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 27 Jul 2015;&nbsp;&nbsp; <span class="generated">Accepted</span>: 27 Nov 2015 </span> </p>
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