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Abstract

In summer 2013, an excess of paediatric cases of haemolytic uraemic syndrome (HUS) in a southern region of Italy prompted the investigation of a community-wide outbreak of Shiga toxin 2-producing (STEC) O26:H11 infections. Case finding was based on testing patients with HUS or bloody diarrhoea for STEC infection by microbiological and serological methods. A case–control study was conducted to identify the source of the outbreak. STEC O26 infection was identified in 20 children (median age 17 months) with HUS, two of whom reported severe neurological sequelae. No cases in adults were detected. Molecular typing showed that two distinct STEC O26:H11 strains were involved. The case–control study showed an association between STEC O26 infection and consumption of dairy products from two local plants, but not with specific ready-to-eat products. O26:H11 strains lacking the genes were isolated from bulk milk and curd samples, but their PFGE profiles did not match those of the outbreak isolates. This outbreak supports the view that infections with Stx2-producing O26 in children have a high probability of progressing to HUS and represent an emerging public health problem in Europe.

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/content/10.2807/1560-7917.ES.2016.21.38.30343
2016-09-22
2020-05-26
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.38.30343
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Community-wide outbreak of haemolytic uraemic syndrome associated with Shiga toxin 2-producing Escherichia coli O26:H11 in southern Italy, summer 2013
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Cinzia+Germinario&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Germinario Cinzia</a>, <a href="/search?value1=Alfredo+Caprioli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Caprioli Alfredo</a>, <a href="/search?value1=Mario+Giordano&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Giordano Mario</a>, <a href="/search?value1=Maria+Chironna&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chironna Maria</a>, <a href="/search?value1=Maria+Serena+Gallone&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gallone Maria Serena</a>, <a href="/search?value1=Silvio+Tafuri&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tafuri Silvio</a>, <a href="/search?value1=Fabio+Minelli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Minelli Fabio</a>, <a href="/search?value1=Antonella+Maugliani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Maugliani Antonella</a>, <a href="/search?value1=Valeria+Michelacci&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Michelacci Valeria</a>, <a href="/search?value1=Luisa+Santangelo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Santangelo Luisa</a>, <a href="/search?value1=Onofrio+Mongelli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mongelli Onofrio</a>, <a href="/search?value1=Cosimo+Montagna&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Montagna Cosimo</a>, <a href="/search?value1=Gaia+Scavia&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Scavia Gaia</a>, <a href="/search?value1=on+behalf+of+all+participants+of+the+Outbreak+investigation+team&option1=author&noRedirect=true" class="nonDisambigAuthorLink">on behalf of all participants of the Outbreak investigation team</a></span>. Community-wide outbreak of haemolytic uraemic syndrome associated with Shiga toxin 2-producing Escherichia coli O26:H11 in southern Italy, summer 2013. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(38):pii=30343. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.38.30343" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.38.30343</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 03 Jul 2015;&nbsp;&nbsp; <span class="generated">Accepted</span>: 18 Oct 2015 </span> </p>
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