- Marjolein J Poen1,2, Josanne H Verhagen1,2, Ruth J Manvell3, Ian Brown3, Theo M Bestebroer1, Stefan van der Vliet1, Oanh Vuong1, Rachel D Scheuer1, Henk P van der Jeugd4,5, Bart A Nolet4,6, Erik Kleyheeg4,5, Gerhard J D M Müskens7, Frank A Majoor8, Christian Grund9, Ron A M Fouchier1
-
View Affiliations Hide AffiliationsAffiliations: 1 Erasmus MC, Department of Viroscience, Rotterdam, the Netherlands 2 These authors contributed equally to this work 3 Animal and Plant Health Agency (APHA) - Weybridge, Addlestone, Surrey, United Kingdom 4 Netherlands Institute of Ecology (NIOO-KNAW), Department of Animal Ecology, Wageningen, the Netherlands 5 Vogeltrekstation – Dutch Centre for Avian Migration and Demography (NIOO-KNAW), Wageningen, the Netherlands 6 University of Amsterdam, Institute of Biodiversity and Ecosystem Dynamics, Computational Geo-Ecology, Amsterdam, the Netherlands 7 Alterra, Center for Ecosystem Studies, Wageningen University, Wageningen, the Netherlands 8 Sovon, Dutch Centre for Field Ornithology, Nijmegen, the Netherland 9 Friedrich-Loeffler-Institut, Greifswald - Insel Riems, GermanyRon A M Fouchierr.fouchier erasmusmc.nl
-
View Citation Hide Citation
Citation style for this article: Poen Marjolein J, Verhagen Josanne H, Manvell Ruth J, Brown Ian, Bestebroer Theo M, van der Vliet Stefan, Vuong Oanh, Scheuer Rachel D, van der Jeugd Henk P, Nolet Bart A, Kleyheeg Erik, Müskens Gerhard J D M, Majoor Frank A, Grund Christian, Fouchier Ron A M. Lack of virological and serological evidence for continued circulation of highly pathogenic avian influenza H5N8 virus in wild birds in the Netherlands, 14 November 2014 to 31 January 2016. Euro Surveill. 2016;21(38):pii=30349. https://doi.org/10.2807/1560-7917.ES.2016.21.38.30349 Received: 05 Apr 2016; Accepted: 21 Jul 2016
Lack of virological and serological evidence for continued circulation of highly pathogenic avian influenza H5N8 virus in wild birds in the Netherlands, 14 November 2014 to 31 January 2016
Abstract
In 2014, H5N8 clade 2.3.4.4 highly pathogenic avian influenza (HPAI) viruses of the A/Goose/Guangdong/1/1996 lineage emerged in poultry and wild birds in Asia, Europe and North America. Here, wild birds were extensively investigated in the Netherlands for HPAI H5N8 virus (real-time polymerase chain reaction targeting the matrix and H5 gene) and antibody detection (haemagglutination inhibition and virus neutralisation assays) before, during and after the first virus detection in Europe in late 2014. Between 21 February 2015 and 31 January 2016, 7,337 bird samples were tested for the virus. One HPAI H5N8 virus-infected Eurasian wigeon (Anas penelope) sampled on 25 February 2015 was detected. Serological assays were performed on 1,443 samples, including 149 collected between 2007 and 2013, 945 between 14 November 2014 and 13 May 2015, and 349 between 1 September and 31 December 2015. Antibodies specific for HPAI H5 clade 2.3.4.4 were absent in wild bird sera obtained before 2014 and present in sera collected during and after the HPAI H5N8 emergence in Europe, with antibody incidence declining after the 2014/15 winter. Our results indicate that the HPAI H5N8 virus has not continued to circulate extensively in wild bird populations since the 2014/15 winter and that independent maintenance of the virus in these populations appears unlikely.

Article metrics loading...

-
From This Site
/content/10.2807/1560-7917.ES.2016.21.38.30349dcterms_title,dcterms_subject,pub_keyword105 -
PubMed
-
Google Scholar

Full text loading...
References
-
Kuiken T. Is low pathogenic avian influenza virus virulent for wild waterbirds? Proc. Biol. Sci. 2013;280(1763):20130990. https://doi.org/http://dx.doi.org/10.1098/rspb.2013.0990 . PMID: 23740783
-
Liu J, Xiao H, Lei F, Zhu Q, Qin K, Zhang XW, et al. Highly pathogenic H5N1 influenza virus infection in migratory birds. Science. 2005;309(5738):1206. https://doi.org/10.1126/science.1115273 PMID: 16000410
-
Zhao K, Gu M, Zhong L, Duan Z, Zhang Y, Zhu Y, et al. Characterization of three H5N5 and one H5N8 highly pathogenic avian influenza viruses in China. Vet Microbiol. 2013;163(3-4):351-7. https://doi.org/10.1016/j.vetmic.2012.12.025 PMID: 23375651
-
Jeong J, Kang HM, Lee EK, Song BM, Kwon YK, Kim HR, et al. Highly pathogenic avian influenza virus (H5N8) in domestic poultry and its relationship with migratory birds in South Korea during 2014. Vet Microbiol. 2014;173(3-4):249-57. https://doi.org/10.1016/j.vetmic.2014.08.002 PMID: 25192767
-
World Organisation for Animal Health (OIE). Update on highly pathogenic avian influenza in animals (typeH5 and H7). Paris: OIE; 2014. [Accessed 02 Feb 2016]. Available from: http://www.oie.int/animal-health-in-the-world/update-on-avian-influenza/2014/
-
World Organisation for Animal Health (OIE). Update on highly pathogenic avian influenza in animals (typeH5 and H7). Paris: OIE; 2015. [Accessed 02 Feb 2016]. Available from: http://www.oie.int/animal-health-in-the-world/update-on-avian-influenza/2015/
-
Verhagen JH, Herfst S, Fouchier RAM. How a virus travels the world. Science. 2015;347(6222):616-7. https://doi.org/10.1126/science.aaa6724 PMID: 25657235
-
Marchenko VY, Susloparov IM, Kolosova NP, Goncharova NI, Shipovalov AV, Durymanov AG, et al. Influenza A(H5N8) virus isolation in Russia, 2014. Arch Virol. 2015;160(11):2857-60. https://doi.org/10.1007/s00705-015-2570-4 PMID: 26306756
-
Hall JS, Dusek RJ, Spackman E. Rapidly Expanding Range of Highly Pathogenic Avian Influenza Viruses. Emerg Infect Dis. 2015;21(7):1251-2. https://doi.org/10.3201/eid2107.150403 PMID: 26079209
-
Kim HM, Kim CK, Lee NJ, Chu H, Kang C, Kim K, et al. Pathogenesis of novel reassortant avian influenza virus A (H5N8) Isolates in the ferret. Virology. 2015;481:136-41. https://doi.org/10.1016/j.virol.2015.02.042 PMID: 25776760
-
Kim YI, Pascua PN, Kwon HI, Lim GJ, Kim EH, Yoon SW, et al. Pathobiological features of a novel, highly pathogenic avian influenza A(H5N8) virus. Emerg Microbes Infect. 2014;3(10):e75. https://doi.org/10.1038/emi.2014.75 PMID: 26038499
-
Richard M, Herfst S, van den Brand JMA, Lexmond P, Bestebroer TM, Rimmelzwaan GF, et al. Low Virulence and Lack of Airborne Transmission of the Dutch Highly Pathogenic Avian Influenza Virus H5N8 in Ferrets. PLoS One. 2015;10(6):e0129827. https://doi.org/10.1371/journal.pone.0129827 PMID: 26090682
-
European Food Safety Authority (EFSA). Highly pathogenic avian influenza A subtype H5N8. EFSA Journal.2014;12(12):3941. https://doi.org/10.2903/j.efsa.2014.3941
-
Verhagen JH, van der Jeugd HP, Nolet BA, Slaterus R, Kharitonov SP, de Vries PP, et al. Wild bird surveillance around outbreaks of highly pathogenic avian influenza A(H5N8) virus in the Netherlands, 2014, within the context of global flyways. Euro Surveill. 2015;20(12):21069. https://doi.org/10.2807/1560-7917.ES2015.20.12.21069 PMID: 25846491
-
Koel BF, van der Vliet S, Burke DF, Bestebroer TM, Bharoto EE, Yasa IWW, et al. Antigenic variation of clade 2.1 H5N1 virus is determined by a few amino acid substitutions immediately adjacent to the receptor binding site. MBio. 2014;5(3):e01070-14. https://doi.org/10.1128/mBio.01070-14 PMID: 24917596
-
Gilbert M, Koel BF, Bestebroer TM, Lewis NS, Smith DJ, Fouchier RAM. Serological evidence for non-lethal exposures of Mongolian wild birds to highly pathogenic avian influenza H5N1 virus. PLoS One. 2014;9(12):e113569. https://doi.org/10.1371/journal.pone.0113569 PMID: 25502318
-
Munster VJ, Baas C, Lexmond P, Bestebroer TM, Guldemeester J, Beyer WE, et al. Practical considerations for high-throughput influenza A virus surveillance studies of wild birds by use of molecular diagnostic tests. J Clin Microbiol. 2009;47(3):666-73. https://doi.org/10.1128/JCM.01625-08 PMID: 19109483
-
Hirst GK. Studies of Antigenic Differences among Strains of Influenza a by Means of Red Cell Agglutination. J Exp Med. 1943;78(5):407-23. https://doi.org/10.1084/jem.78.5.407 PMID: 19871338
-
World Organisation for Animal Health (OIE). Ch. 2.3.4. Avian Influenza (infection with avian influenza viruses). OIE Terrestrial Manual 2015. Paris: OIE; 2015. [Accessed 02 Feb 2016]. Available from: http://www.oie.int/fileadmin/Home/eng/Health_standards/tahm/2.03.04_AI.pdf
-
Rimmelzwaan GF, Baars M, van Beek R, de Lijster P, de Jong JC, Claas EC, et al. Influenza virus subtype cross-reactivities of haemagglutination inhibiting and virus neutralising serum antibodies induced by infection or vaccination with an ISCOM-based vaccine. Vaccine. 1999;17(20-21):2512-6. https://doi.org/10.1016/S0264-410X(99)00063-8 PMID: 10418897
-
Kim HR, Kwon YK, Jang I, Lee YJ, Kang HM, Lee EK, et al. Pathologic changes in wild birds infected with highly pathogenic avian influenza A(H5N8) viruses, South-Korea, 2014. Emerg Infect Dis. 2015;21(5):775-80. https://doi.org/10.3201/eid2105.141967 PMID: 25897841
-
Brown J, Poulson R, Carter D, Lebarbenchon C, Pantin-Jackwood M, Spackman E, et al. Susceptibility of avian species to North American H13 low pathogenic avian influenza viruses. Avian Dis. 2012;56(4) Suppl;969-75. https://doi.org/10.1637/10158-040912-Reg.1 PMID: 23402121
-
Tolf C, Latorre-Margalef N, Wille M, Bengtsson D, Gunnarsson G, Grosbois V, et al. Individual variation in influenza A virus infection histories and long-term immune responses in Mallards. PLoS One. 2013;8(4):e61201. https://doi.org/10.1371/journal.pone.0061201 PMID: 23637797
-
Verhagen JH, Höfle U, van Amerongen G, van de Bildt M, Majoor F, Fouchier RAM, et al. Long-Term Effect of Serial Infections with H13 and H16 Low-Pathogenic Avian Influenza Viruses in Black-Headed Gulls. J Virol. 2015;89(22):11507-22. https://doi.org/10.1128/JVI.01765-15 PMID: 26339062
-
Wibawa H, Henning J, Waluyati DE, Usman TB, Lowther S, Bingham J, et al. Comparison of serological assays for detecting antibodies in ducks exposed to H5 subtype avian influenza virus. BMC Vet Res. 2012;8:117. https://doi.org/10.1186/1746-6148-8-117 PMID: 22823985

Data & Media loading...
