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Abstract

Conjugate vaccines have reduced pneumococcal disease in vaccinated children and unvaccinated adults, but non-vaccine serotypes are of concern, particularly if antibiotic resistant. We reviewed collected via: (i) the British Society for Antimicrobial Chemotherapy (BSAC) surveillances from 2001–2014; (ii) Public Health England’s (PHE) invasive isolate surveillance from 2005–2014 and (iii) referral to PHE for resistance investigation from 2005–2014. Serotype 15A increased in all series, with many representatives showing triple resistance to macrolides, tetracyclines and penicillin. 15A was consistently among the 10 most prevalent serotypes from 2011 in PHE and BSAC invasive isolate/bacteraemia surveillance but never previously; 26–33% of these invasive 15A isolates had triple resistance. BSAC respiratory isolates were only serotyped in 2013/14 and 2014/15 (October to September); 15A was most prevalent serotype in both periods, comprising 9–11% of isolates, 38–48% of them with triple resistance. Serotype 15A represented 0–4% of referred to PHE for reference investigation annually until 2008 but rose to 29% (2013) and 32% (2014). Almost all multidrug-resistant 15A isolates were sequence type (ST) 63 variants, whereas susceptible 15A isolates were clonally diverse. The rise of serotype 15A suggests that pneumococcal conjugate vaccines will need ongoing adaptation.

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/content/10.2807/1560-7917.ES.2016.21.50.30423
2016-12-15
2023-03-24
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.50.30423
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Rise of multidrug-resistant non-vaccine serotype 15A Streptococcus pneumoniae in the United Kingdom, 2001 to 2014
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Carmen+Sheppard&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sheppard Carmen</a>, <a href="/search?value1=Norman+K.+Fry&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fry Norman K.</a>, <a href="/search?value1=Shazad+Mushtaq&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mushtaq Shazad</a>, <a href="/search?value1=Neil+Woodford&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Woodford Neil</a>, <a href="/search?value1=Rosy+Reynolds&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Reynolds Rosy</a>, <a href="/search?value1=Regina+Janes&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Janes Regina</a>, <a href="/search?value1=Rachel+Pike&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pike Rachel</a>, <a href="/search?value1=Robert+Hill&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hill Robert</a>, <a href="/search?value1=Maimuna+Kimuli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kimuli Maimuna</a>, <a href="/search?value1=Peter+Staves&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Staves Peter</a>, <a href="/search?value1=Michel+Doumith&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Doumith Michel</a>, <a href="/search?value1=Timothy+Harrison&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Harrison Timothy</a>, <a href="/search?value1=David+M+Livermore&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Livermore David M</a></span>. Rise of multidrug-resistant non-vaccine serotype 15A Streptococcus pneumoniae in the United Kingdom, 2001 to 2014. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(50):pii=30423. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.50.30423" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.50.30423</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 19 Mar 2016;&nbsp;&nbsp; <span class="generated">Accepted</span>: 17 Aug 2016 </span> </p>
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