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Plasmid-mediated colistin resistance (- gene): three months later, the story unfolds, Page 1 of 1

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  1. Liu YY, Wang Y, Walsh TR, Yi LX, Zhang R, Spencer J, et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis. 2016;16(2):161-8.  https://doi.org/10.1016/S1473-3099(15)00424-7  PMID: 26603172 
  2. Kluytmans–van den Bergh M, Huizinga P, Bonten M, Bos M, De Bruyne K, Friedrich A, et al. Presence of mcr-1-positive Enterobacteriaceae in retail chicken meat but not in humans in the Netherlands since 2009. Euro Surveill. 2016;21(9):30149.  https://doi.org/10.2807/1560-7917.ES.2016.21.9.30149 
  3. Arcilla MS, van Hattem JM, Matamoros S, Melles DC, Penders J, de Jong MD, et al. Dissemination of the mcr-1 colistin resistance gene. Lancet Infect Dis. 2016;16(2):147-9.  https://doi.org/10.1016/S1473-3099(15)00541-1  PMID: 26711361 
  4. Battisti A. Antibiotic resistance – Italy: colistin, MCR-1, E. coli, turkeys 2014. ProMEDmail 20160113.3933461 (12 January 2016).Available from: http://www.promedmail.org/post/3933461
  5. Bonten MJ. [Antimicrobial resistance: is it really all going wrong now?]. Ned Tijdschr Geneeskd. 2015;160(0):D81. Dutch. PMID: 26860752 
  6. Du H, Chen L, Tang YW, Kreiswirth BN. Emergence of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae. Lancet Infect Dis. 2016;16(3):287-8.  https://doi.org/10.1016/S1473-3099(16)00056-6  PMID: 26842776 
  7. Falgenhauer L, Waezsada SE, Yao Y, Imirzalioglu C, Käsbohrer A, Roesler U, et al. Colistin resistance gene mcr-1 in extended-spectrum β-lactamase-producing and carbapenemase-producing Gram-negative bacteria in Germany. Lancet Infect Dis. 2016;16(3):282-3.  https://doi.org/10.1016/S1473-3099(16)00009-8  PMID: 26774242 
  8. Bakterie resistent mot sista behandlingsalternativet funnen. [Bacteria resistant to the last treatment option found]. Press release. Stockholm: Folkhälsomyndigheten; 10 February 2016. Swedish. Available from: http://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2016/februari/bakterie-resistent-mot-sista-behandlingsalternativet-funnen/
  9. Grami R, Mansour W, Mehri W, Bouallègue O, Boujaâfar N, Madec J, et al. Impact of food animal trade on the spread of mcr-1-mediated colistin resistance, Tunisia, July 2015. Euro Surveill. 2016;21(8):30144.  https://doi.org/10.2807/1560-7917.ES.2016.21.8.30144 
  10. Haenni M, Poirel L, Kieffer N, Châtre P, Saras E, Métayer V, et al. Co-occurrence of extended spectrum β lactamase and MCR-1 encoding genes on plasmids. Lancet Infect Dis. 2016;16(3):281-2.  https://doi.org/10.1016/S1473-3099(16)00007-4  PMID: 26774244 
  11. Hasman H, Hammerum AM, Hansen F, Hendriksen RS, Olesen B, Agersø Y, et al. Detection of mcr-1 encoding plasmid-mediated colistin-resistant Escherichia coli isolates from human bloodstream infection and imported chicken meat, Denmark 2015. Euro Surveill. 2015;20(49):30085.  https://doi.org/10.2807/1560-7917.ES.2015.20.49.30085  PMID: 26676364 
  12. Hu Y, Liu F, Lin IY, Gao GF, Zhu B. Dissemination of the mcr-1 colistin resistance gene. Lancet Infect Dis. 2016;16(2):146-7.  https://doi.org/10.1016/S1473-3099(15)00533-2  PMID: 26711359 
  13. Malhotra-Kumar S, Xavier BB, Das AJ, Lammens C, Butaye P, Goossens H. Colistin resistance gene mcr-1 harboured on a multidrug resistant plasmid. Lancet Infect Dis. 2016;16(3):283-4.  https://doi.org/10.1016/S1473-3099(16)00012-8  PMID: 26774247 
  14. Malhotra-Kumar S, Xavier BB, Das AJ, Lammens C, Hoang HT, Pham NT, et al. Colistin-resistant Escherichia coli harbouring mcr-1 isolated from food animals in Hanoi, Vietnam. Lancet Infect Dis. 2016;16(3):286-7.  https://doi.org/10.1016/S1473-3099(16)00014-1  PMID: 26774248 
  15. Mulvey MR, Mataseje LF, Robertson J, Nash JHE, Boerlin P, Toye B, et al. Dissemination of the mcr-1 colistin resistance gene. Lancet Infect Dis. 2016;16(3):289-90.
  16. Perrin-Guyomard A, Bruneau M, Houée P, Deleurme K, Legrandois P, Poirier C, et.al. Prevalence of mcr-1 in commensal Escherichia coli from French livestock, 2007 to 2014. Euro Surveill. 2016; 11;21(6):pii=30135. doi:  https://doi.org/10.2807/1560-7917.ES.2016.21.6.30135 .
  17. Petrillo M, Angers-Loustau A, Kreysa J. Possible genetic events producing colistin resistance gene mcr-1. Lancet Infect Dis. 2016;16(3):280-1.  https://doi.org/10.1016/S1473-3099(16)00005-0  PMID: 26774240 
  18. Poirel L, Kieffer N, Liassine N, Thanh D, Nordmann P. Plasmid-mediated carbapenem and colistin resistance in a clinical isolate of Escherichia coli. Lancet Infect Dis. 2016;16(3):281.  https://doi.org/10.1016/S1473-3099(16)00006-2  PMID: 26774246 
  19. Public Health England (PHE). First detection of plasmid-mediated colistin resistance (mcr-1 gene) in food and human isolates in England and Wales (Serial number 2015/090). London: PHE; 2015.
  20. Ruppé E, Le Chatelier E, Pons N, Andremont A, Dusko Ehrlich S. Dissemination of the mcr-1 colistin resistance gene. Lancet Infect Dis. 2016;16(3):290-1.  https://doi.org/10.1016/S1473-3099(16)00066-9 
  21. Shen Z, Wang Y, Shen Y, Shen J, Wu C. Early emergence of mcr-1 in Escherichia coli from food-producing animals. Lancet Infect Dis. 2016;16(3):293.  https://doi.org/10.1016/S1473-3099(16)00061-X 
  22. Stoesser N, Mathers AJ, Moore CE, Day NP, Crook DW. Colistin resistance gene mcr-1 and pHNSHP45 plasmid in human isolates of Escherichia coli and Klebsiella pneumoniae. Lancet Infect Dis. 2016;16(3):285-6.  https://doi.org/10.1016/S1473-3099(16)00010-4  PMID: 26774239 
  23. Suzuki S, Ohnishi M, Kawanishi M, Akiba M, Kuroda M. Investigation of a plasmid genome database for colistin-resistance gene mcr-1. Lancet Infect Dis. 2016;16(3):284-5.  https://doi.org/10.1016/S1473-3099(16)00008-6  PMID: 26774245 
  24. Thanh DP, Tuyen HT, Nguyen TN, The HC, Wick RR, Thwaites G, et al. Inducible colistin resistance via a disrupted plasmid-borne mcr-1 gene in a 2008 Vietnamese Shigella sonnei isolate. bioRxiv 2016 (preprint first posted online, Feb. 18, 2016). doi: http://dx.doi.org/ https://doi.org/10.1101/039925 
  25. Tse H, Yuen KY. Dissemination of the mcr-1 colistin resistance gene. Lancet Infect Dis. 2016;16(2):145-6.  https://doi.org/10.1016/S1473-3099(15)00532-0  PMID: 26711362 
  26. Webb HE, Granier SA, Marault M, Millemann Y, den Bakker HC, Nightingale KK, et al. Dissemination of the mcr-1 colistin resistance gene. Lancet Infect Dis. 2016;16(2):144-5.  https://doi.org/10.1016/S1473-3099(15)00538-1  PMID: 26711363 
  27. Yao X, Doi Y, Zeng L, Lv L, Liu JH. Carbapenem-resistant and colistin-resistant Escherichia coli co-producing NDM-9 and MCR-1. Lancet Infect Dis. 2016;16(3):288-9.  https://doi.org/10.1016/S1473-3099(16)00057-8  PMID: 26842777 
  28. Zhang R, Huang Y, Chan EW, Zhou H, Chen S. Dissemination of the mcr-1 colistin resistance gene. Lancet Infect Dis. 2016;16(3):291-2.  https://doi.org/10.1016/S1473-3099(16)00062-1 
  29. Zurfuh K, Poirel L, Nordmann P, Nüesch-Inderbinen M, Hächler H, Stephan R. Occurrence of the plasmid-borne mcr-1 colistin resistance gene in ESBL-producing Enterobacteriaceae in river water and imported vegetable samples in Switzerland. Antimicrob Agents Chemother. 2016 Feb 16. pii: AAC.00066-16.
  30. Olaitan AO, Chabou S, Okdah L, Morand S, Rolain JM. Dissemination of the mcr-1 colistin resistance gene. Lancet Infect Dis. 2016;16(2):147.  https://doi.org/10.1016/S1473-3099(15)00540-X  PMID: 26711360 
  31. Kempf I, Fleury MA, Drider D, Bruneau M, Sanders P, Chauvin C, et al. What do we know about resistance to colistin in Enterobacteriaceae in avian and pig production in Europe? Int J Antimicrob Agents. 2013;42(5):379-83.  https://doi.org/10.1016/j.ijantimicag.2013.06.012  PMID: 24076115 
  32. European Medicines Agency (EMA). Sales of veterinary antimicrobial agents in 26 EU/EEA countries in 2013. Fifth ESVAC report ESVAC. EMA/387934/2015. London: EMA; 2015. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Report/2015/10/WC500195687.pdf
  33. Committee for Medicinal Products for Veterinary Use (CVMP). Annexes to the opinion following an Article 35 referral for veterinary medicinal products containing colistin to be administered orally. London: EMA; 2015. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/Colistin_oral_35/WC500185447.pdf
  34. Committee for Medicinal Products for Veterinary Use (CVMP). Opinion following an Article 35 referral for veterinary medicinal products containing colistin to be administered orally. London: EMA; 2015. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/Colistin_oral_35/WC500185448.pdf
  35. European Medicines Agency (EMA). Recommendations on the use of antibiotics in animals. London: EMA. [Accessed March 1, 2016]. Available from: http://www.ema.europa.eu/ema/index.jsp?curl=pages/regulation/general/general_content_000639.jsp&mid=WC0b01ac058080a585
  36. European Centre for Disease Prevention and Control (ECDC). Summary of the latest data on antibiotic consumption in the European Union. ESAC-Net data. November 2015. Stockholm: ECDC; 2015. Available from: http://ecdc.europa.eu/en/eaad/antibiotics-news/Documents/antimicrobial-consumption-ESAC-Net-summary-2015.pdf
  37. European Centre for Disease Prevention and Control (ECDC). Antimicrobial resistance surveillance in Europe 2014. Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). Stockholm: ECDC; 2015. Available from: http://ecdc.europa.eu/en/publications/Publications/antimicrobial-resistance-europe-2014.pdf
  38. Monaco M, Giani T, Raffone M, Arena F, Garcia-Fernandez A, Pollini S, et al. Colistin resistance superimposed to endemic carbapenem-resistant Klebsiella pneumoniae: a rapidly evolving problem in Italy, November 2013 to April 2014. Euro Surveill. 2014;19(42):20939.  https://doi.org/10.2807/1560-7917.ES2014.19.42.20939  PMID: 25358041 
  39. European Centre for Disease Prevention and Control (ECDC), European Food Safety Authority (EFSA) and European Medicines Agency (EMA). ECDC/EFSA/EMA first joint report on the integrated analysis of the consumption of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from humans and food-producing animals. Joint Interagency Antimicrobial Consumption and Resistance Analysis (JIACRA) Report. Stockholm/Parma/London: ECDC/EFSA/EMA; 2015. Available from: http://ecdc.europa.eu/en/publications/Publications/antimicrobial-resistance-JIACRA-report.pdf
  40. European Committee on Antimicrobial Susceptibility Testing (EUCAST). Breakpoint tables for interpretation of MICs and zone diameters. Version 6.0. EUCAST; 2016.. Available from: http://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Breakpoint_tables/v_6.0_Breakpoint_table.pdf

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