1887
  1. Home
  2. Eurosurveillance
  3. Volume 22, Issue 1, 05/Jan/2017
  4. Article
Rapid communication Open Access
Like 0
Download

Abstract

A novel genotype of H5N6 influenza viruses was isolated from migratory birds in South Korea during November 2016. Domestic outbreaks of this virus were associated with die-offs of wild birds near reported poultry cases in Chungbuk province, central South Korea. Genetic analysis and animal studies demonstrated that the Korean H5N6 viruses are highly pathogenic avian influenza (HPAI) viruses and that these viruses are novel reassortants of at least three different subtypes (H5N6, H4N2 and H1N1).

© Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Closure
A corrected article has been published for this content:
Erratum for Euro Surveill. 2017;22(1)
Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2017.22.1.30434
2017-01-05
2025-07-04
/content/10.2807/1560-7917.ES.2017.22.1.30434
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/22/1/eurosurv-22-30434-1.html?itemId=/content/10.2807/1560-7917.ES.2017.22.1.30434&mimeType=html&fmt=ahah

References

  1. Patel S, Waugh J, Millar CD, Lambert DM. Conserved primers for DNA barcoding historical and modern samples from New Zealand and Antarctic birds. Mol Ecol Resour. 2010;10(3):431-8.  https://doi.org/10.1111/j.1755-0998.2009.02793.x 
  2. Richard M, Herfst S, van den Brand JM, Lexmond P, Bestebroer TM, Rimmelzwaan GF, et al. Low virulence and lack of airborne transmission of the Dutch highly pathogenic avian influenza virus H5N8 in ferrets. PLoS One. 2015;10(6):e0129827.  https://doi.org/10.1371/journal.pone.0129827 
  3. Yang H, Carney PJ, Mishin VP, Guo Z, Chang JC, Wentworth DE, et al. Molecular Characterizations of Surface Proteins Hemagglutinin and Neuraminidase from Recent H5Nx Avian Influenza Viruses. J Virol. 2016;90(12):5770-84.  https://doi.org/10.1128/JVI.00180-16 
  4. Gu M, Liu W, Cao Y, Peng D, Wang X, Wan H, et al. Novel reassortant highly pathogenic avian influenza (H5N5) viruses in domestic ducks, China. Emerg Infect Dis. 2011;17(6):1060-3.  https://doi.org/10.3201/eid/1706.101406 
  5. Kim Y-I, Pascua PNQ, Kwon H-I, Lim G-J, Kim E-H, Yoon S-W, et al. Pathobiological features of a novel, highly pathogenic avian influenza A(H5N8) virus. Emerg Microbes Infect. 2014;3(10):e75.  https://doi.org/10.1038/emi.2014.75 
  6. Bouwstra RJ, Koch G, Heutink R, Harders F, van der Spek A, Elbers AR, et al. Phylogenetic analysis of highly pathogenic avian influenza A(H5N8) virus outbreak strains provides evidence for four separate introductions and one between-poultry farm transmission in the Netherlands, November 2014. Euro Surveill. 2015;20(26):21174.  https://doi.org/10.2807/1560-7917.ES2015.20.26.21174 
  7. Ip HS, Torchetti MK, Crespo R, Kohrs P, DeBruyn P, Mansfield KG, et al. Novel Eurasian highly pathogenic avian influenza A H5 viruses in wild birds, Washington, USA, 2014. Emerg Infect Dis. 2015;21(5):886-90.  https://doi.org/10.3201/eid2105.142020 
  8. Wong FY, Phommachanh P, Kalpravidh W, Chanthavisouk C, Gilbert J, Bingham J, et al. Reassortant highly pathogenic influenza A(H5N6) virus in Laos. Emerg Infect Dis. 2015;21(3):511-6.  https://doi.org/10.3201/eid2103.141488 
  9. Sun H, Pu J, Wei Y, Sun Y, Hu J, Liu L, et al. Highly pathogenic avian influenza H5N6 viruses exhibit enhanced affinity for human type sialic acid receptor and in-contact transmission in model ferrets. J Virol. 2016;90(14):6235-43.  https://doi.org/10.1128/JVI.00127-16 
  10. World Health Organization (WHO). Influenza at the human-animal interface. Geneva: WHO; 2016. [Accessed 18 Nov 2016]. Available from: http://www.who.int/influenza/human_animal_interface/Influenza_Summary_IRA_HA_interface_11_15_2016.pdf
  11. World Organisation for Animal Health (OIE). Update on highly pathogenic avian influenza in animals (TYPE H5 and H7). Paris: OIE; 2016. [Accessed 29 Dec 2016]. Available from: http://www.oie.int/animal-health-in-the-world/update-on-avian-influenza/2016/
  12. Mok CKP, Da Guan W, Liu XQ, Lamers MM, Li XB, Wang M, et al. Genetic characterization of highly pathogenic avian influenza A (H5N6) virus, Guangdong, China. Emerg Infect Dis. 2015;21(12):2268-71.  https://doi.org/10.3201/eid2112.150809 
  13. He J, Duan J. First human case of avian influenza A (H5N6) in Yunnan province, China. SAGE Open Med Case Rep. 2015 Aug 4. doi:  https://doi.org/10.1177/2050313X15596484 . eCollection 2015. https://doi.org/10.1177/2050313X15596484 
  14. Watanabe Y, Ibrahim MS, Ellakany HF, Kawashita N, Mizuike R, Hiramatsu H, et al. Acquisition of human-type receptor binding specificity by new H5N1 influenza virus sublineages during their emergence in birds in Egypt. PLoS Pathog. 2011;7(5):e1002068.  https://doi.org/10.1371/journal.ppat.1002068 
  15. Zhu X, Viswanathan K, Raman R, Yu W, Sasisekharan R, Wilson IA. Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants. Cell Reports. 2015;13(8):1683-91.  https://doi.org/10.1016/j.celrep.2015.10.027 
  16. Zamarin D, Ortigoza MB, Palese P. Influenza A virus PB1-F2 protein contributes to viral pathogenesis in mice. J Virol. 2006;80(16):7976-83.  https://doi.org/10.1128/JVI.00415-06 
  17. Das K, Ma L-C, Xiao R, Radvansky B, Aramini J, Zhao L, et al. Structural basis for suppression of a host antiviral response by influenza A virus. Proc Natl Acad Sci USA. 2008;105(35):13093-8.  https://doi.org/10.1073/pnas.0805213105 
  18. Soubies SM, Volmer C, Croville G, Loupias J, Peralta B, Costes P, et al. Species-specific contribution of the four C-terminal amino acids of influenza A virus NS1 protein to virulence. J Virol. 2010;84(13):6733-47.  https://doi.org/10.1128/JVI.02427-09 
  19. World Organisation for Animal Health (OIE). OIE Terrestrial Manual 2015. Chapter 2.3.4 Avian influenza (Infection with avian influenza viruses). Paris: OIE; 2015. [Accessed 8 Jun 2016]. Available from http://www.oie.int/fileadmin/Home/eng/Health_standards/tahm/2.03.04_AI.pdf
  20. Lycett SJ, Bodewes R, Pohlmann A, Banks J, Bányai K, Boni MF, et al. Global Consortium for H5N8 and Related Influenza Viruses. Role for migratory wild birds in the global spread of avian influenza H5N8. Science. 2016;354(6309):213-7.  https://doi.org/10.1126/science.aaf8852 
Genetic characterisation of novel, highly pathogenic avian influenza (HPAI) H5N6 viruses isolated in birds, South Korea, November 2016
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Young-Jae+Si&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Si Young-Jae</a>, <a href="/search?value1=In+Won+Lee&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lee In Won</a>, <a href="/search?value1=Eun-Ha+Kim&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kim Eun-Ha</a>, <a href="/search?value1=Young-Il+Kim&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kim Young-Il</a>, <a href="/search?value1=Hyeok-Il+Kwon&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kwon Hyeok-Il</a>, <a href="/search?value1=Su-Jin+Park&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Park Su-Jin</a>, <a href="/search?value1=Hiep+Dinh+Nguyen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nguyen Hiep Dinh</a>, <a href="/search?value1=Se+Mi+Kim&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kim Se Mi</a>, <a href="/search?value1=Jin-Jung+Kwon&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kwon Jin-Jung</a>, <a href="/search?value1=Won-Suk+Choi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Choi Won-Suk</a>, <a href="/search?value1=Yun+Hee+Beak&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Beak Yun Hee</a>, <a href="/search?value1=Min-Suk+Song&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Song Min-Suk</a>, <a href="/search?value1=Chul-Joong+Kim&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kim Chul-Joong</a>, <a href="/search?value1=Richard+J.+Webby&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Webby Richard J.</a>, <a href="/search?value1=Young-Ki+Choi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Choi Young-Ki</a></span>. Genetic characterisation of novel, highly pathogenic avian influenza (HPAI) H5N6 viruses isolated in birds, South Korea, November 2016. <a href="/content/ecdc">Euro Surveill.</a> 2017;22(1):pii=30434. <a href="https://doi.org/10.2807/1560-7917.ES.2017.22.1.30434" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2017.22.1.30434</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 08 Dec 2016;&nbsp;&nbsp; <span class="generated">Accepted</span>: 05 Jan 2017 </span> </p>
/content/10.2807/1560-7917.ES.2017.22.1.30434
/content/10.2807/1560-7917.ES.2017.22.1.30434
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error