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A Dutch traveller returning from Suriname in early March 2017, presented with fever and severe acute liver injury. Yellow fever was diagnosed by (q)RT-PCR and sequencing. During hospital stay, the patient’s condition deteriorated and she developed hepatic encephalopathy requiring transfer to the intensive care. Although yellow fever has not been reported in the last four decades in Suriname, vaccination is recommended by the World Health Organization for visitors to this country.


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  1. Paules CI, Fauci AS. Yellow Fever - Once Again on the Radar Screen in the Americas. N Engl J Med. 8 Mar 2017;NEJMp1702172. [Epub ahead of print]. PMID: 28273000 
  2. Pan American Health Organization / World Health Organization (PAHO/WHO). Epidemiological Update Yellow Fever 9 March. Washington, D.C. PAHO/WHO; 2017. Available from: http://www.paho.org/hq/index.php?option=com_topics&view=readall&cid=2194&Itemid=40784&lang=en
  3. Panning M, Grywna K, van Esbroeck M, Emmerich P, Drosten C. Chikungunya fever in travelers returning to Europe from the Indian Ocean region, 2006. Emerg Infect Dis. 2008;14(3):416-22.  https://doi.org/10.3201/eid1403.070906  PMID: 18325256 
  4. Scaramozzino N, Crance JM, Jouan A, DeBriel DA, Stoll F, Garin D. Comparison of flavivirus universal primer pairs and development of a rapid, highly sensitive heminested reverse transcription-PCR assay for detection of flaviviruses targeted to a conserved region of the NS5 gene sequences. J Clin Microbiol. 2001;39(5):1922-7.  https://doi.org/10.1128/JCM.39.5.1922-1927.2001  PMID: 11326014 
  5. Charlier N, Molenkamp R, Leyssen P, Paeshuyse J, Drosten C, Panning M, et al. Exchanging the yellow fever virus envelope proteins with Modoc virus prM and E proteins results in a chimeric virus that is neuroinvasive in SCID mice. J Virol. 2004;78(14):7418-26.  https://doi.org/10.1128/JVI.78.14.7418-7426.2004  PMID: 15220415 
  6. Drosten C, Göttig S, Schilling S, Asper M, Panning M, Schmitz H, et al. Rapid detection and quantification of RNA of Ebola and Marburg viruses, Lassa virus, Crimean-Congo hemorrhagic fever virus, Rift Valley fever virus, dengue virus, and yellow fever virus by real-time reverse transcription-PCR. J Clin Microbiol. 2002;40(7):2323-30.  https://doi.org/10.1128/JCM.40.7.2323-2330.2002  PMID: 12089242 
  7. Monath TP. Yellow fever: an update. Lancet Infect Dis. 2001;1(1):11-20.  https://doi.org/10.1016/S1473-3099(01)00016-0  PMID: 11871403 
  8. Pinto CS, Confalonieri UE, Mascarenhas BM. Ecology of Haemagogus sp. and Sabethes sp. (Diptera: Culicidae) in relation to the microclimates of the Caxiuanã National Forest, Pará, Brazil. Mem Inst Oswaldo Cruz. 2009;104(4):592-8.  https://doi.org/10.1590/S0074-02762009000400010  PMID: 19722082 
  9. Dhawan R, Kumar M, Mohanty AK, Dey G, Advani J, Prasad TS, et al. Mosquito-Borne Diseases and Omics: Salivary Gland Proteome of the Female Aedes aegypti Mosquito. OMICS. 2017;21(1):45-54.  https://doi.org/10.1089/omi.2016.0160  PMID: 28271980 
  10. Cavalcante KR, Tauil PL. Epidemiological characteristics of yellow fever in Brazil, 2000-2012. Epidemiol Serv Saude. 2016 Jan-Mar;25(1):11-20
  11. Jentes ES, Poumerol G, Gershman MD, Hill DR, Lemarchand J, Lewis RF, et al. Informal WHO Working Group on Geographic Risk for Yellow Fever. The revised global yellow fever risk map and recommendations for vaccination, 2010: consensus of the Informal WHO Working Group on Geographic Risk for Yellow Fever. Lancet Infect Dis. 2011;11(8):622-32.  https://doi.org/10.1016/S1473-3099(11)70147-5  PMID: 21798462 
  12. Monath TP, Vasconcelos PF. Yellow fever. J Clin Virol. 2015;64:160-73.  https://doi.org/10.1016/j.jcv.2014.08.030  PMID: 25453327 
  13. De Haas RA, Oostburg BF, Sitalsing AD, Bellot SM. Isolation of yellow fever virus from a human liver obtained by autopsy in Surinam. Trop Geogr Med. 1971;23(1):59-63. PMID: 5573581 
  14. World Health Organization (WHO). WHO and UNICEF Estimates of National Infant Immunization Coverage. Geneva: WHO; [Accessed 13 March 2017]. Available from: http://www.who.int/immunization/monitoring_surveillance/routine/coverage/en/index4.html
  15. Colebunders R. Imported case of confirmed yellow fever detected in Belgium. Euro Surveill. 2001;5(47):2058.
  16. Centers for Disease Control and Prevention (CDC). Fatal yellow fever in a traveler returning from Venezuela, 1999. MMWR Morb Mortal Wkly Rep. 2000;49(14):303-5. PMID: 10825087 
  17. ProMED Mail. Yellow fever - China (03): ex Angola. Archive. 2016;4106312(: 20160319):19. Available from: http://www.promedmail.org/post/4106312
  18. European Centre for Disease Prevention and Control (ECDC). Rapid risk assessment; outbreak of yellow fever in Brazil –25 January 2017 Stockholm: ECDC; 2017. Available from: http://ecdc.europa.eu/en/publications/Publications/Risk-assessment-yellow-fever-outbreak-Brazil-25-jan-2017.pdf
  19. European Centre for Disease Prevention and Control (ECDC). Communicable disease threats report -18 Feb 2017 Stockholm: ECDC. Available from: http://ecdc.europa.eu/en/publications/Publications/communicable-disease-threats-report-18-feb-2017.pdf
  20. Amraoui F, Vazeille M, Failloux AB. French Aedes albopictus are able to transmit yellow fever virus. Euro Surveill. 2016;21(39):30361.  https://doi.org/10.2807/1560-7917.ES.2016.21.39.30361  PMID: 27719755 
  21. World Health Organization (WHO). WHO International travel and health, annex 1 – update – as of 16 Feb 2017. Geneva: WHO. Available from: http://www.who.int/ith/2017-ith-annex1.pdf?ua=1&ua=1
  22. World Health Organization (WHO). International Health Regulations (2005). Geneva: WHO. Available from: http://www.who.int/topics/international_health_regulations/en/

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