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Abstract

In 2013, raw pork was the suspected vehicle of a large outbreak (n = 203 cases) of Muenchen in the German federal state of Saxony. In 2014, we investigated an outbreak (n = 247 cases) caused by the same serovar affecting Saxony and three further federal states in the eastern part of Germany. Evidence from epidemiological, microbiological and trace-back investigations strongly implicated different raw pork products as outbreak vehicles. Trace-back analysis of . Muenchen-contaminated raw pork sausages narrowed the possible source down to 54 pig farms, and . Muenchen was detected in three of them, which traded animals with each other. One of these farms had already been the suspected source of the 2013 outbreak. . Muenchen isolates from stool of patients in 2013 and 2014 as well as from food and environmental surface swabs of the three pig farms shared indistinguishable pulsed-field gel electrophoresis patterns. Our results indicate a common source of both outbreaks in the primary production of pigs. Current European regulations do not make provisions for control measures on pig farms that have been involved in human disease outbreaks. In order to prevent future outbreaks, legislators should consider tightening regulations for control in causative primary production settings.

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/content/10.2807/1560-7917.ES.2017.22.18.30528
2017-05-04
2024-04-19
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.18.30528
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References

  1. European Centre for Disease Prevention and Control (ECDC). Annual epidemiological report on communicable diseases in Europe 2005. Stockholm: ECDC; 2005.
  2. European Centre for Disease Prevention and Control (ECDC). Annual epidemiological report 2014 –food- and waterborne diseases and zoonoses. Stockholm: ECDC; 2014.
  3. Mughini-Gras L, Smid J, Enserink R, Franz E, Schouls L, Heck M, et al. Tracing the sources of human salmonellosis: a multi-model comparison of phenotyping and genotyping methods. Infect Genet Evol. 2014;28:251-60.  https://doi.org/10.1016/j.meegid.2014.10.003  PMID: 25315490 
  4. EFSA (European Food Safety Authority) and ECDC. (European Centre for Disease Prevention and Control), 2015. The European Union summary report on trends and sources of zoonoses, zoonotic agents and food-borne outbreaks in 2014. EFSA J. 2015;13(12):4329.
  5. Hauser E, Tietze E, Helmuth R, Junker E, Blank K, Prager R, et al. Pork contaminated with Salmonella enterica serovar 4,[5],12:i:-, an emerging health risk for humans. Appl Environ Microbiol. 2010;76(14):4601-10.  https://doi.org/10.1128/AEM.02991-09  PMID: 20472721 
  6. German Infectious Diseases Notification Data Base “SurvNet”. Berlin: Robert Koch Institute. [Accessed Dec 2015].
  7. Frank C, Käsbohrer A, Stark K, Werber D. Marked decrease in reporting incidence of salmonellosis driven by lower rates of Salmonella Enteritidis infections in Germany in 2008: a continuing trend. Euro Surveill. 2009;14(11):19154. PMID: 19317980 
  8. Alt K, Simon S, Helmeke C, Kohlstock C, Prager R, Tietze E, et al. Outbreak of uncommon O4 non-agglutinating Salmonella typhimurium linked to minced pork, Saxony-Anhalt, Germany, January to April 2013. PLoS One. 2015;10(6):e0128349.  https://doi.org/10.1371/journal.pone.0128349  PMID: 26030424 
  9. Frank C, Werber D, Askar M, Blümel B, Rabsch W, Simon C, et al. Catering risky food to those at-risk: Salmonella Derby outbreak among the elderly in Berlin, December 2013/January 2014. Proceedings of the European Scientific Conference on Applied Infectious Disease; 2014 Nov 5-7 Stockholm: European Centre for Disease Prevention and Control; 2014. Available at: http://www.ecdc.europa.eu/en/ESCAIDE/programme/abstract-book/Documents/ECSAIDE-2014-abstracts.PDF
  10. Schroeder S, Harries M, Prager R, Höfig A, Ahrens B, Hoffmann L, et al. A prolonged outbreak of Salmonella Infantis associated with pork products in central Germany, April-October 2013. Epidemiol Infect. 2016;144(7):1429-39. PMID: 26593246 
  11. Weiser AA, Gross S, Schielke A, Wigger JF, Ernert A, Adolphs J, et al. Trace-back and trace-forward tools developed ad hoc and used during the STEC O104:H4 outbreak 2011 in Germany and generic concepts for future outbreak situations. Foodborne Pathog Dis. 2013;10(3):263-9.  https://doi.org/10.1089/fpd.2012.1296  PMID: 23268760 
  12. Weiser AA, Thöns C, Filter M, Falenski A, Appel B, Käsbohrer A. FoodChain-Lab: A Trace-Back and Trace-Forward Tool Developed and Applied during Food-Borne Disease Outbreak Investigations in Germany and Europe. PLoS One. 2016;11(3):e0151977.  https://doi.org/10.1371/journal.pone.0151977  PMID: 26985673 
  13. Ribot EM, Fair MA, Gautom R, Cameron DN, Hunter SB, Swaminathan B, et al. Standardization of pulsed-field gel electrophoresis protocols for the subtyping of Escherichia coli O157:H7, Salmonella, and Shigella for PulseNet. Foodborne Pathog Dis. 2006;3(1):59-67.  https://doi.org/10.1089/fpd.2006.3.59  PMID: 16602980 
  14. European Commission. Commission Regulation (EC) No 2160/2003 of 17 November 2003 on the control of Salmonella and other specified food-borne zoonotic agents. Official Journal of the European Union. Luxembourg: Publications Office of the European Union. 12.12.2003:L 325. Available from: http://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:32003R2160&qid=1491494533578&from=EN
  15. The pig production hygiene regulation. [Schweinehaltungshygieneverordnung (SchHaltHygV)] of 7 June 1999, in the version published 2 April 2014 (Federal Law Gazette I, p. 326), as amended by the ordination of 29 December 2014 (Federal Law Gazette I, p. 2481). German
  16. The pig Salmonella ordinance. [Schweine-Salmonellen-Verordnung (SchwSalmoV)] of 13 March 2007 (Federal Law Gazette I, p. 322), as amended by the ordination of 17 April 2014 (Federal Law Gazette I, p. 388).German.
  17. European Commission. Commission Regulation (EC) No 178/2002 of the European Parliament and of the Council of 28 January 2002 laying down the general principles and requirements of food law, establishing the European Food Safety Authority and laying down procedures in matters of food safety. Official Journal of the European Union. Luxembourg: Publications Office of the European Union. 01.02.2002: L 031. Available from: http://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:32002R0178&qid=1491495356095&from=EN
  18. The Foods, Consumer Goods and Feedstuffs Code. [Lebensmittel-Bedarfsgegenstände- und Futtermittelgesetzbuch (LFGB)] of 1 September 2005 in the version published 3 June 2013 (Federal Law Gazette I, p. 1426), as amended by the ordination of 5 December 2014 (Federal Law Gazette I, p. 1975). German
  19. European Commission. Commission Regulation (EC) No 2073/2005 of 15 November 2005 on microbiological criteria for foodstuffs. Official Journal of the European Union. Luxembourg: Publications Office of the European Union. 22.12.2005: L 338. Available from: http://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:32005R2073&rid=1
  20. BfR. Leaflet on protecting especially vulnerable sections of the population from food-borne infections. [Sicher verpflegt: Besonders empfindliche Personengruppen in Gemeinschaftseinrichtunge]. Press release 44/2011; published 22.12.2011. German
  21. DIN standard 10506:2012-3 of March 2012: “Food hygiene - Mass catering”.
  22. Rosner BM, Stark K, Höhle M, Werber D. Risk factors for sporadic Yersinia enterocolitica infections, Germany 2009-2010. Epidemiol Infect. 2012;140(10):1738-47.  https://doi.org/10.1017/S0950268811002664  PMID: 22313798 
  23. Wilking H, Thamm M, Stark K, Aebischer T, Seeber F. Prevalence, incidence estimations, and risk factors of Toxoplasma gondii infection in Germany: a representative, cross-sectional, serological study. Sci Rep. 2016;6(1):22551.  https://doi.org/10.1038/srep22551  PMID: 26936108 
  24. EFSA (European Food Safety Authority). Scientific Opinion on a Quantitative Microbiological Risk Assessment of Salmonella in slaughter and breeder pigs. EFSA J. 2010;8(4):1547.  https://doi.org/10.2903/j.efsa.2010.1547 
  25. Callaway TR, Morrow JL, Edrington TS, Genovese KJ, Dowd S, Carroll J, et al. Social stress increases fecal shedding of Salmonella typhimurium by early weaned piglets. Curr Issues Intest Microbiol. 2006;7(2):65-71. PMID: 16875421 
  26. Methner U, Rammler N, Fehlhaber K, Rösler U. Salmonella status of pigs at slaughter--bacteriological and serological analysis. Int J Food Microbiol. 2011;151(1):15-20.  https://doi.org/10.1016/j.ijfoodmicro.2011.07.028  PMID: 21872961 
  27. Wegener HC, Hald T, Wong DLF, Madsen M, Korsgaard H, Bager F, et al. Salmonella control programs in Denmark. Emerg Infect Dis. 2003;9(7):774-80.  https://doi.org/10.3201/eid0907.030024  PMID: 12890316 
  28. Stevens MP, Humphrey TJ, Maskell DJ. Molecular insights into farm animal and zoonotic Salmonella infections. Philos Trans R Soc Lond B Biol Sci. 2009;364(1530):2709-23.  https://doi.org/10.1098/rstb.2009.0094  PMID: 19687040 
  29. Wales AD, Cook AJ, Davies RH. Producing Salmonella-free pigs: a review focusing on interventions at weaning. Vet Rec. 2011;168(10):267-76.  https://doi.org/10.1136/vr.d1125  PMID: 21498180 
Two consecutive large outbreaks of Salmonella Muenchen linked to pig farming in Germany, 2013 to 2014: Is something missing in our regulatory framework?
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Anika+Schielke&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schielke Anika</a>, <a href="/search?value1=Wolfgang+Rabsch&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rabsch Wolfgang</a>, <a href="/search?value1=Rita+Prager&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Prager Rita</a>, <a href="/search?value1=Sandra+Simon&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Simon Sandra</a>, <a href="/search?value1=Angelika+Fruth&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fruth Angelika</a>, <a href="/search?value1=R%C3%BCdiger+Helling&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Helling Rüdiger</a>, <a href="/search?value1=Martin+Schnabel&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schnabel Martin</a>, <a href="/search?value1=Claudia+Siffczyk&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Siffczyk Claudia</a>, <a href="/search?value1=Sina+Wieczorek&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wieczorek Sina</a>, <a href="/search?value1=Sabine+Schroeder&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schroeder Sabine</a>, <a href="/search?value1=Beate+Ahrens&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ahrens Beate</a>, <a href="/search?value1=Hanna+Oppermann&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Oppermann Hanna</a>, <a href="/search?value1=Stefan+Pfeiffer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pfeiffer Stefan</a>, <a href="/search?value1=Sophie+Susann+Merbecks&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Merbecks Sophie Susann</a>, <a href="/search?value1=Bettina+Rosner&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rosner Bettina</a>, <a href="/search?value1=Christina+Frank&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Frank Christina</a>, <a href="/search?value1=Armin+A.+Weiser&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Weiser Armin A.</a>, <a href="/search?value1=Petra+Luber&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Luber Petra</a>, <a href="/search?value1=Andreas+Gilsdorf&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gilsdorf Andreas</a>, <a href="/search?value1=Klaus+Stark&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Stark Klaus</a>, <a href="/search?value1=Dirk+Werber&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Werber Dirk</a></span>. Two consecutive large outbreaks of Salmonella Muenchen linked to pig farming in Germany, 2013 to 2014: Is something missing in our regulatory framework?. <a href="/content/ecdc">Euro Surveill.</a> 2017;22(18):pii=30528. <a href="https://doi.org/10.2807/1560-7917.ES.2017.22.18.30528" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2017.22.18.30528</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 01 Jun 2016;&nbsp;&nbsp; <span class="generated">Accepted</span>: 15 Nov 2016 </span> </p>
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