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Abstract

A new rapid assay for detecting oseltamivir resistance in influenza virus, iART, was used to test 149 clinical specimens. Results were obtained for 132, with iART indicating 41 as ‘resistant’. For these, sequence analysis found known and suspected markers of oseltamivir resistance, while no such markers were detected for the remaining 91 samples. Viruses isolated from the 41 specimens showed reduced or highly reduced inhibition by neuraminidase inhibition assay. iART may facilitate broader antiviral resistance testing.

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/content/10.2807/1560-7917.ES.2017.22.18.30529
2017-05-04
2025-01-18
/content/10.2807/1560-7917.ES.2017.22.18.30529
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Monitoring influenza virus susceptibility to oseltamivir using a new rapid assay, iART
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Larisa+V+Gubareva&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gubareva Larisa V</a>, <a href="/search?value1=Eric+Fallows&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fallows Eric</a>, <a href="/search?value1=Vasiliy+P+Mishin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mishin Vasiliy P</a>, <a href="/search?value1=Erin+Hodges&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hodges Erin</a>, <a href="/search?value1=Abdullah+Brooks&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Brooks Abdullah</a>, <a href="/search?value1=John+Barnes&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Barnes John</a>, <a href="/search?value1=Alicia+M+Fry&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fry Alicia M</a>, <a href="/search?value1=William+Kramp&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kramp William</a>, <a href="/search?value1=Roxanne+Shively&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Shively Roxanne</a>, <a href="/search?value1=David+E+Wentworth&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wentworth David E</a>, <a href="/search?value1=Kristin+Weidemaier&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Weidemaier Kristin</a>, <a href="/search?value1=Ross+Jacobson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jacobson Ross</a></span>. Monitoring influenza virus susceptibility to oseltamivir using a new rapid assay, iART. <a href="/content/ecdc">Euro Surveill.</a> 2017;22(18):pii=30529. <a href="https://doi.org/10.2807/1560-7917.ES.2017.22.18.30529" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2017.22.18.30529</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 11 Apr 2017;&nbsp;&nbsp; <span class="generated">Accepted</span>: 04 May 2017 </span> </p>
/content/10.2807/1560-7917.ES.2017.22.18.30529
/content/10.2807/1560-7917.ES.2017.22.18.30529
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